FASN (fatty acid synthase) - Rat Genome Database

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Gene: FASN (fatty acid synthase) Sus scrofa
Analyze
Symbol: FASN
Name: fatty acid synthase
RGD ID: 13909291
Description: ENCODES a protein that exhibits fatty acid synthase activity (ortholog); identical protein binding (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); cellular response to interleukin-4 (ortholog); establishment of endothelial intestinal barrier (ortholog); PARTICIPATES IN fatty acid biosynthetic pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Animal Disease Models (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); glycogen granule (ortholog); INTERACTS WITH aldehydo-D-glucose; D-glucose; glucose
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12920,507 - 937,559 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112922,405 - 937,560 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,023,512 - 1,032,662 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:12755829   PMID:16513975   PMID:18772430   PMID:26345771   PMID:26965892   PMID:29058795  


Genomics

Comparative Map Data
FASN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12920,507 - 937,559 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112922,405 - 937,560 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,023,512 - 1,032,662 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FASN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1782,078,338 - 82,098,294 (-)EnsemblGRCh38hg38GRCh38
GRCh381782,078,338 - 82,098,303 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371780,036,214 - 80,056,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,629,503 - 77,649,395 (-)NCBINCBI36hg18NCBI36
Build 341777,629,503 - 77,649,395NCBI
Celera1776,630,560 - 76,648,850 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1775,436,168 - 75,456,057 (-)NCBIHuRef
CHM1_11780,122,440 - 80,142,272 (-)NCBICHM1_1
Fasn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,696,784 - 120,715,992 (-)NCBIGRCm39mm39
GRCm39 Ensembl11120,696,672 - 120,715,373 (-)Ensembl
GRCm3811120,805,958 - 120,825,166 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,805,846 - 120,824,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,667,272 - 120,685,861 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611120,623,167 - 120,640,332 (-)NCBImm8
Celera11132,542,449 - 132,561,038 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.56NCBI
Fasn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210106,072,093 - 106,090,259 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl10106,072,091 - 106,090,261 (-)Ensembl
Rnor_6.010109,987,735 - 110,005,901 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,987,735 - 110,005,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,579,051 - 109,597,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10104,615,873 - 104,634,039 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Fasn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,063,002 - 1,079,939 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,063,002 - 1,079,939 (+)NCBIChiLan1.0ChiLan1.0
FASN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11782,187,516 - 82,205,647 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,187,516 - 82,205,647 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01776,483,108 - 76,503,148 (-)NCBIMhudiblu_PPA_v0panPan3
FASN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19233,105 - 249,573 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9232,963 - 249,092 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha9835,096 - 852,365 (+)NCBI
ROS_Cfam_1.09826,552 - 843,813 (+)NCBI
UMICH_Zoey_3.19851,506 - 868,761 (+)NCBI
UNSW_CanFamBas_1.09978,401 - 995,678 (+)NCBI
UU_Cfam_GSD_1.091,056,702 - 1,073,992 (+)NCBI
Fasn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602802,978 - 820,174 (+)NCBI
SpeTri2.0NW_0049365945,591,785 - 5,609,886 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,988,410 - 74,008,374 (-)NCBI
ChlSab1.1 Ensembl1673,982,899 - 74,006,551 (-)Ensembl
Vero_WHO_p1.0NW_02366607745,523,735 - 45,543,679 (-)NCBI
Fasn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480110,910,022 - 10,926,505 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 12 1
Low 10 3 3 3 2 11 2 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000026033   ⟹   ENSSSCP00000021889
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl12920,507 - 937,222 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000029960   ⟹   ENSSSCP00000021647
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl12920,507 - 937,559 (+)Ensembl
RefSeq Acc Id: NM_001099930   ⟹   NP_001093400
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.112922,405 - 937,560 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001093400   ⟸   NM_001099930
- UniProtKB: A5YV76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000021647   ⟸   ENSSSCT00000029960
RefSeq Acc Id: ENSSSCP00000021889   ⟸   ENSSSCT00000026033
Protein Domains
Carrier   PKS_AT   PKS_DH   PKS_KS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029944 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000021647 UniProtKB/TrEMBL
  ENSSSCP00000021889 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000026033 UniProtKB/TrEMBL
  ENSSSCT00000029960 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1200.10 UniProtKB/TrEMBL
  1.10.1470.20 UniProtKB/TrEMBL
  3.10.129.110 UniProtKB/TrEMBL
  3.40.366.10 UniProtKB/TrEMBL
  3.40.47.10 UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Ac_transferase_dom_sf UniProtKB/TrEMBL
  ACP-like_sf UniProtKB/TrEMBL
  Acyl_transferase UniProtKB/TrEMBL
  Acyl_Trfase/lysoPLipase UniProtKB/TrEMBL
  ADH_C UniProtKB/TrEMBL
  Fatty_acid_synthase_dom_2 UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/TrEMBL
  KAsynt_C_assoc UniProtKB/TrEMBL
  Ketoacyl_synth_AS UniProtKB/TrEMBL
  Ketoacyl_synth_C UniProtKB/TrEMBL
  Ketoacyl_synth_N UniProtKB/TrEMBL
  Malonyl_transacylase_ACP-bd UniProtKB/TrEMBL
  Methyltransf_12 UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  PKS_Beta-ketoAc_synthase_dom UniProtKB/TrEMBL
  PKS_dehydratase UniProtKB/TrEMBL
  PKS_dehydratase_sf UniProtKB/TrEMBL
  PKS_ER UniProtKB/TrEMBL
  PKS_KR UniProtKB/TrEMBL
  PKS_PP-bd UniProtKB/TrEMBL
  PP-bd_ACP UniProtKB/TrEMBL
  Ppantetheine_attach_site UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
  Thioesterase UniProtKB/TrEMBL
  Thiolase-like UniProtKB/TrEMBL
KEGG Report ssc:397561 UniProtKB/TrEMBL
NCBI Gene FASN ENTREZGENE
Pfam Acyl_transf_1 UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/TrEMBL
  KAsynt_C_assoc UniProtKB/TrEMBL
  ketoacyl-synt UniProtKB/TrEMBL
  Ketoacyl-synt_C UniProtKB/TrEMBL
  Methyltransf_12 UniProtKB/TrEMBL
  PF08659 UniProtKB/TrEMBL
  PP-binding UniProtKB/TrEMBL
  PS-DH UniProtKB/TrEMBL
  Thioesterase UniProtKB/TrEMBL
PROSITE B_KETOACYL_SYNTHASE UniProtKB/TrEMBL
  CARRIER UniProtKB/TrEMBL
  PHOSPHOPANTETHEINE UniProtKB/TrEMBL
SMART PKS_AT UniProtKB/TrEMBL
  PKS_DH UniProtKB/TrEMBL
  PKS_ER UniProtKB/TrEMBL
  PKS_KS UniProtKB/TrEMBL
  PKS_PP UniProtKB/TrEMBL
Superfamily-SCOP SSF47336 UniProtKB/TrEMBL
  SSF50129 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
  SSF52151 UniProtKB/TrEMBL
  SSF53335 UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
  SSF53901 UniProtKB/TrEMBL
  SSF55048 UniProtKB/TrEMBL
UniProt A0A1L1YNR3_PIG UniProtKB/TrEMBL
  A5YV76 ENTREZGENE, UniProtKB/TrEMBL
  F8SM59_PIG UniProtKB/TrEMBL
  I3LC73_PIG UniProtKB/TrEMBL
  I3LCW1_PIG UniProtKB/TrEMBL
  Q58G70_PIG UniProtKB/TrEMBL
  Q58GK8_PIG UniProtKB/TrEMBL
  Q866R7_PIG UniProtKB/TrEMBL
  Q9GLD4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88016 ENTREZGENE