RGD Reference Report - Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats.

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Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats.
Authors:	Huong, DT Ide, T
Citation:	Huong DT and Ide T, Br J Nutr. 2008 Jul;100(1):79-87. Epub 2007 Dec 7.
RGD ID:	2317315
Pubmed:	PMID:18062843 (View Abstract at PubMed)
DOI:	DOI:10.1017/S0007114507876227 (Journal Full-text)
Effects of dietary alpha-lipoic acid on hepatic and serum lipid concentrations and the activity and mRNA levels of lipogenic enzymes were examined in rats. Rats were fed experimental diets containing varying amounts of lipoic acid (0, 1, 2.5, 5 g/kg) for 21 d. Lipoic acid profoundly decreased serum and liver concentrations of TAG, and also lowered serum concentrations of phospholipid and NEFA, and the concentration of cholesterol in the liver. A hypoglycaemic effect of this compound was also observed. Lipoic acid dose-dependently decreased the activity and mRNA levels of fatty acid synthase, ATP-citrate lyase, glucose 6-phosphate dehydrogenase, malic enzyme and pyruvate kinase in the liver despite that reductions were considerably attenuated in the NADPH-producing enzymes. This compound also dose-dependently lowered the mRNA levels of spot 14, adiponutrin, stearoyl-CoA desaturase 1, and Delta5- and Delta6-desaturases. In addition, lipoic acid dose-dependently lowered serum concentrations of insulin and leptin, but increased those of adiponectin. Lipoic acid appeared to reduce hepatic lipogenesis and hence decreases serum and liver lipid levels. Alterations in serum concentrations of insulin and (or) adiponectin may trigger this consequence.

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Biological Process

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Acly	Rat	acetyl-CoA metabolic process		IDA			RGD
Fasn	Rat	acetyl-CoA metabolic process		IDA			RGD
Acly	Rat	citrate metabolic process		IDA			RGD

Molecular Function

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Acly	Rat	ATP citrate synthase activity		IDA			RGD
Fasn	Rat	fatty acid synthase activity		IDA			RGD
G6pd	Rat	glucose-6-phosphate dehydrogenase activity		IDA			RGD
Me1	Rat	malic enzyme activity		IDA			RGD
Pklr	Rat	pyruvate kinase activity		IDA			RGD

Objects Annotated

Genes (Rattus norvegicus)

Acly (ATP citrate lyase)

Fasn (fatty acid synthase)

G6pd (glucose-6-phosphate dehydrogenase)

Me1 (malic enzyme 1)

Pklr (pyruvate kinase L/R)

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Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats.