Fosl2 (FOS like 2, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fosl2 (FOS like 2, AP-1 transcription factor subunit) Heterocephalus glaber
Analyze
Symbol: Fosl2
Name: FOS like 2, AP-1 transcription factor subunit
RGD ID: 18916966
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); ASSOCIATED WITH APLASIA CUTIS-ENAMEL DYSPLASIA SYNDROME (ortholog); colon adenocarcinoma (ortholog); colorectal cancer (ortholog); FOUND IN nucleoplasm (ortholog); RNA polymerase II transcription regulator complex (ortholog); transcription factor AP-1 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Fos-related antigen 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473810,370,103 - 10,391,623 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473810,370,479 - 10,391,623 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alveolar secondary septum development  (ISO)
B cell differentiation  (ISO)
B cell proliferation  (ISO)
bone development  (ISO)
bone mineralization  (ISO)
cartilage development  (ISO)
cell morphogenesis  (ISO)
chondrocyte differentiation  (ISO)
chondrocyte proliferation  (ISO)
circadian rhythm  (ISO)
collagen biosynthetic process  (ISO)
collagen metabolic process  (ISO)
conditioned taste aversion  (ISO)
fat cell apoptotic process  (ISO)
fat cell differentiation  (ISO)
fat pad development  (ISO)
female pregnancy  (ISO)
gene expression  (ISO)
glucose homeostasis  (ISO)
growth plate cartilage development  (ISO)
homeostasis of number of cells  (ISO)
homeostasis of number of cells within a tissue  (ISO)
inflammatory response  (ISO)
inflammatory response to antigenic stimulus  (ISO)
innate immune response  (ISO)
insulin metabolic process  (ISO)
keratinocyte development  (ISO)
lung alveolus development  (ISO)
lung connective tissue development  (ISO)
lung development  (ISO)
macrophage differentiation  (ISO)
mucus secretion  (ISO)
multicellular organism growth  (ISO)
myofibroblast differentiation  (ISO)
neutrophil differentiation  (ISO)
NK T cell differentiation  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
osteoclast differentiation  (ISO)
photoperiodism  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of myofibroblast differentiation  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to bleomycin  (ISO)
response to cAMP  (ISO)
response to cytokine  (ISO)
response to estradiol  (ISO)
response to forskolin  (ISO)
response to glucocorticoid  (ISO)
response to Gram-positive bacterium  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to interleukin-13  (ISO)
response to interleukin-7  (ISO)
response to leukemia inhibitory factor  (ISO)
response to light stimulus  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to peptide hormone  (ISO)
response to progesterone  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
smooth muscle tissue development  (ISO)
T cell differentiation  (ISO)
T cell receptor signaling pathway  (ISO)
tissue remodeling  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fosl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473810,370,103 - 10,391,623 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473810,370,479 - 10,391,623 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
FOSL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38228,392,858 - 28,417,317 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl228,392,448 - 28,417,317 (+)EnsemblGRCh38hg38GRCh38
GRCh37228,615,725 - 28,640,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36228,469,283 - 28,491,020 (+)NCBINCBI36Build 36hg18NCBI36
Build 34228,527,429 - 28,549,165NCBI
Celera228,460,891 - 28,482,629 (+)NCBICelera
Cytogenetic Map2p23.2NCBI
HuRef228,356,103 - 28,377,836 (+)NCBIHuRef
CHM1_1228,546,510 - 28,568,245 (+)NCBICHM1_1
T2T-CHM13v2.0228,436,151 - 28,460,588 (+)NCBIT2T-CHM13v2.0
Fosl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39532,292,599 - 32,315,184 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl532,293,145 - 32,315,186 (+)EnsemblGRCm39 Ensembl
GRCm38532,136,472 - 32,157,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl532,135,801 - 32,157,842 (+)EnsemblGRCm38mm10GRCm38
MGSCv37532,438,845 - 32,460,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36532,413,115 - 32,434,421 (+)NCBIMGSCv36mm8
MGSCv36530,804,839 - 30,826,510 (+)NCBIMGSCv36mm8
Celera529,588,696 - 29,629,647 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.33NCBI
Fosl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,017,952 - 30,039,269 (-)NCBIGRCr8
mRatBN7.2624,297,898 - 24,319,219 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,300,956 - 24,320,034 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx624,601,426 - 24,618,764 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0624,917,309 - 24,934,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0624,406,268 - 24,423,562 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,598,936 - 25,616,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,598,936 - 25,616,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0635,422,541 - 35,440,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera623,796,496 - 23,813,256 (-)NCBICelera
Cytogenetic Map6q14NCBI
Fosl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546910,297,179 - 10,319,180 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546910,297,179 - 10,319,180 (+)NCBIChiLan1.0ChiLan1.0
FOSL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21298,097,276 - 98,121,829 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A98,100,630 - 98,125,163 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A28,392,328 - 28,416,838 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A28,485,271 - 28,498,815 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A28,485,613 - 28,498,397 (+)Ensemblpanpan1.1panPan2
FOSL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11722,340,469 - 22,364,994 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1722,341,322 - 22,361,772 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1722,136,634 - 22,160,204 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01722,904,688 - 22,928,247 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1722,904,806 - 22,928,863 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,204,175 - 22,227,721 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,256,447 - 22,279,983 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01722,372,895 - 22,396,457 (+)NCBIUU_Cfam_GSD_1.0
Fosl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629266,512,413 - 66,535,167 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364934,304,395 - 4,327,179 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364934,308,683 - 4,327,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOSL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3110,823,666 - 110,843,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13110,820,403 - 110,842,903 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23117,487,534 - 117,495,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOSL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11479,201,128 - 79,222,363 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1479,201,649 - 79,222,373 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604532,919,208 - 32,943,579 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000015125   ⟹   ENSHGLP00000014975
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473810,370,103 - 10,391,623 (+)Ensembl
RefSeq Acc Id: XM_004839228   ⟹   XP_004839285
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473810,370,484 - 10,391,623 (+)NCBI
RefSeq Acc Id: XM_004839229   ⟹   XP_004839286
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473810,371,941 - 10,391,623 (+)NCBI
RefSeq Acc Id: XM_004839230   ⟹   XP_004839287
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473810,371,294 - 10,391,623 (+)NCBI
RefSeq Acc Id: XM_021253644   ⟹   XP_021109303
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473810,370,479 - 10,391,623 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004839285 (Get FASTA)   NCBI Sequence Viewer  
  XP_004839286 (Get FASTA)   NCBI Sequence Viewer  
  XP_004839287 (Get FASTA)   NCBI Sequence Viewer  
  XP_021109303 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB15900 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014975
  ENSHGLP00000036660
  ENSHGLP00100018854
GenBank Protein JAO02073 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021109303   ⟸   XM_021253644
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004839285   ⟸   XM_004839228
- Peptide Label: isoform X1
- UniProtKB: G5C2Y9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004839287   ⟸   XM_004839230
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004839286   ⟸   XM_004839229
- Peptide Label: isoform X3
Ensembl Acc Id: ENSHGLP00000014975   ⟸   ENSHGLT00000015125


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010716 Ensembl, ENTREZGENE
  ENSHGLG00000046142 UniProtKB/TrEMBL
  ENSHGLG00100013912 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000015125 ENTREZGENE
  ENSHGLT00000077729 UniProtKB/TrEMBL
  ENSHGLT00100019051 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
InterPro AP-1 UniProtKB/TrEMBL
  bZIP UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
KEGG Report hgl:101696928 UniProtKB/TrEMBL
NCBI Gene Fosl2 ENTREZGENE
PANTHER PTHR23351 UniProtKB/TrEMBL
  PTHR23351:SF25 UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/TrEMBL
PRINTS LEUZIPPRFOS UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/TrEMBL
UniProt G5C2Y9 ENTREZGENE, UniProtKB/TrEMBL