RGD Reference Report - Immediate early response protein 2 promotes the migration and invasion of hepatocellular carcinoma cells via regulating the activity of Rho GTPases. - Rat Genome Database

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Immediate early response protein 2 promotes the migration and invasion of hepatocellular carcinoma cells via regulating the activity of Rho GTPases.

Authors: Xu, X  Zhou, W  Chen, Y  Wu, K  Wang, H  Zhang, J  Zhou, Y  Zeng, J  Yang, J  Deng, Z  Zhang, Y  Shen, W 
Citation: Xu X, etal., Neoplasma. 2020 May;67(3):614-622. doi: 10.4149/neo_2020_190818N781. Epub 2020 Feb 3.
RGD ID: 153323326
Pubmed: PMID:32009420   (View Abstract at PubMed)
DOI: DOI:10.4149/neo_2020_190818N781   (Journal Full-text)

Human immediate early response 2 (IER2) has been implicated in tumor cell motility and metastasis; however, the underlying mechanisms in hepatocellular carcinoma (HCC) metastasis remain to be clarified. In this study, we demonstrate that dysregulation of IER2 was shown in HCC clinical samples, and IER2 expression resulted in the promotion of cell migration and invasion in vitro, and HCC tumor growth and pulmonary metastasis in vivo. Moreover, we showed that IER2 expression altered assembly of the actin cytoskeleton rearrangement. Furthermore, MAPK and PI3K/Akt signaling pathways induced by IER2 were confirmed to be probably involved in regulating the activity of Rho GTPases, such as RhoA, Rac1 and Cdc42. Collectively, our results indicated a significant role of IER2 in the HCC cell motility and metastasis through MAPK and PI3K/Akt signaling pathways to regulate the activity of Rho GTPases, thereby modulating actin cytoskeleton rearrangement, unveiling a novel mechanism of cell motility regulation induced by IER2.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IER2Humanhepatocellular carcinoma  IEP mRNA and protein:decreased expression:liver (human)RGD 
IER2Humanhepatocellular carcinoma  IMP human cells in mouse modelRGD 
Ier2Rathepatocellular carcinoma  ISOIER2 (Homo sapiens)mRNA and protein:decreased expression:liver (human)RGD 
Ier2Mousehepatocellular carcinoma  ISOIER2 (Homo sapiens)mRNA and protein:decreased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ier2  (immediate early response 2)

Genes (Mus musculus)
Ier2  (immediate early response 2)

Genes (Homo sapiens)
IER2  (immediate early response 2)


Additional Information