Ier2 (immediate early response 2) - Rat Genome Database
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Gene: Ier2 (immediate early response 2) Mus musculus
Analyze
Symbol: Ier2
Name: immediate early response 2
RGD ID: 1552809
MGI Page MGI
Description: Predicted to be involved in several processes, including neuron differentiation; positive regulation of transcription by RNA polymerase II; and response to fibroblast growth factor. Localizes to cytoplasm. Is expressed in several structures, including ear; forelimb bud; submandibular gland primordium; tooth; and vibrissa. Orthologous to human IER2 (immediate early response 2); INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI317238; Ch1; CHX1; cycloheximide-induced gene protein; growth factor-inducible immediate early protein; immediate early response gene 2 protein; pi; Pip92; proline-rich-induced protein 92; T-lymphocyte-activated protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,387,960 - 85,389,481 (-)NCBIGRCm39mm39
GRCm38884,661,331 - 84,662,852 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,661,331 - 84,662,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,185,230 - 87,186,751 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,549,656 - 87,552,953 (-)NCBImm8
Celera888,961,236 - 88,962,757 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
amphetamine  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
dimethyl sulfoxide  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
ellagic acid  (ISO)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
glycidol  (ISO)
hydrogen peroxide  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
mercury dichloride  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA,ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

Additional References at PubMed
PMID:7671812   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14747749   PMID:15142957   PMID:15489334   PMID:15747579   PMID:16141072   PMID:16141073  
PMID:16782087   PMID:21267068   PMID:22120713   PMID:22465667   PMID:26238476  


Genomics

Comparative Map Data
Ier2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,387,960 - 85,389,481 (-)NCBIGRCm39mm39
GRCm38884,661,331 - 84,662,852 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,661,331 - 84,662,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,185,230 - 87,186,751 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,549,656 - 87,552,953 (-)NCBImm8
Celera888,961,236 - 88,962,757 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.02NCBI
IER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,150,411 - 13,154,911 (+)EnsemblGRCh38hg38GRCh38
GRCh381913,150,411 - 13,154,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,261,282 - 13,265,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,122,282 - 13,126,722 (+)NCBINCBI36hg18NCBI36
Build 341913,122,281 - 13,126,716NCBI
Celera1913,151,680 - 13,156,120 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,833,675 - 12,838,116 (+)NCBIHuRef
CHM1_11913,262,236 - 13,266,676 (+)NCBICHM1_1
Ier2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,774,146 - 25,775,670 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,774,143 - 25,775,659 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,750,509 - 36,752,033 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,159,276 - 25,160,800 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,164,101 - 25,165,622 (+)NCBI
Celera1923,048,157 - 23,049,681 (+)NCBICelera
Cytogenetic Map19q11NCBI
Ier2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,159,935 - 32,160,624 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,159,762 - 32,161,530 (+)NCBIChiLan1.0ChiLan1.0
IER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,449,491 - 13,452,925 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,452,239 - 13,452,910 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,714,804 - 12,718,213 (+)NCBIMhudiblu_PPA_v0panPan3
IER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2049,072,234 - 49,072,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12049,071,243 - 49,074,184 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ier2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,176,962 - 2,179,900 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1265,909,638 - 65,912,491 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,210,147 - 66,211,956 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IER2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl611,836,706 - 11,837,377 (+)Ensembl
ChlSab1.1611,834,998 - 11,838,421 (+)NCBI
Ier2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901684,313 - 686,488 (+)NCBI

Position Markers
RH136174  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,662,694 - 84,662,797UniSTSGRCm38
MGSCv37887,186,593 - 87,186,696UniSTSGRCm37
Celera888,962,599 - 88,962,702UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.4UniSTS
M59821  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,661,481 - 84,661,619UniSTSGRCm38
MGSCv37887,185,380 - 87,185,518UniSTSGRCm37
Celera888,961,386 - 88,961,524UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.4UniSTS
Whitehead/MRC_RH81006.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:298
Count of miRNA genes:224
Interacting mature miRNAs:251
Transcripts:ENSMUST00000060427
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000060427   ⟹   ENSMUSP00000060275
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,661,331 - 84,662,854 (-)Ensembl
RefSeq Acc Id: NM_010499   ⟹   NP_034629
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,387,960 - 85,389,481 (-)NCBI
GRCm38884,661,331 - 84,662,852 (-)ENTREZGENE
MGSCv37887,185,230 - 87,186,751 (-)RGD
Celera888,961,236 - 88,962,757 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034629   ⟸   NM_010499
- UniProtKB: P17950 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000060275   ⟸   ENSMUST00000060427

Promoters
RGD ID:8667669
Promoter ID:EPDNEW_M11866
Type:multiple initiation site
Name:Ier2_1
Description:Mus musculus immediate early response 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,662,852 - 84,662,912EPDNEW
RGD ID:6842534
Promoter ID:MM_KWN:55078
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK015406_4930447I22RIK,   NM_010499
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36887,183,916 - 87,187,622 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104815 AgrOrtholog
Ensembl Genes ENSMUSG00000053560 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000060275 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000060427 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro IER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15936 UniProtKB/Swiss-Prot
MGD MGI:104815 ENTREZGENE
NCBI Gene 15936 ENTREZGENE
PANTHER PTHR15895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ier2 PhenoGen
UniGene Mm.399 ENTREZGENE
UniProt IER2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3T9S0_MOUSE UniProtKB/TrEMBL
  Q3U7A5_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TD12 UniProtKB/Swiss-Prot
  Q64251 UniProtKB/Swiss-Prot
  Q8BME8 UniProtKB/Swiss-Prot
  Q99M25 UniProtKB/Swiss-Prot