RGD Reference Report - [Association of cellular inhibitor of apoptosis protein-2 expression with clinical outcomes of hepatocellular carcinoma]. - Rat Genome Database

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[Association of cellular inhibitor of apoptosis protein-2 expression with clinical outcomes of hepatocellular carcinoma].

Authors: Bi, Minping  Yang, Dinghua  Li, Xianghong  Zhong, Kebo  Liu, Yan  Li, Guanghui  Liao, Xiaoming  Liu, Xiao 
Citation: Bi M, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2012 Jun;32(7):1020-5, 1030.
RGD ID: 152998986
Pubmed: PMID:22820591   (View Abstract at PubMed)


OBJECTIVE: To study the expression of cellular inhibitor of apoptosis protein-2 (C-IAP2) mRNA and protein in hepatocellular carcinoma (HCC) and its relationship with the clinical outcomes.
METHODS: Quantitative PCR and immunohistochemical staining were used to detect the expression of C-IAP2 mRNA and protein in the tumor tissues and corresponding adjacent non-cancerous tissues from HCC patients.
RESULTS: The expression of C-IAP2 mRNA in HCC tissues was 2.70 folds higher than that in the non-cancerous tissues (P<0.001). The expression rate of C-IAP2 protein in HCC tissues was 70.8%, significantly higher than that in the non-cancerous tissues (27.8%, P=0.001). The expression of C-IAP2 mRNA and protein was associated with the tumor emboli, lymph node metastasis, AFP level, histological differentiation, TNM stage, postoperative recurrence and metastasis (P<0.05), but not with the patients' gender, age, HbsAg positivity, number of tumors, cirrhosis or the presence of tumor encapsulation (P>0.05).
CONCLUSION: The expression of C-IAP2 in HCC is associated with tumor recurrence and metastasis, and can be a biological marker for prognostic evaluation of HCC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BIRC3Humanhepatocellular carcinoma exacerbatesIEP mRNA and protein:increased expression:liver (human)RGD 
Birc3Rathepatocellular carcinoma exacerbatesISOBIRC3 (Homo sapiens)mRNA and protein:increased expression:liver (human)RGD 
Birc3Mousehepatocellular carcinoma exacerbatesISOBIRC3 (Homo sapiens)mRNA and protein:increased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Birc3  (baculoviral IAP repeat-containing 3)

Genes (Mus musculus)
Birc3  (baculoviral IAP repeat-containing 3)

Genes (Homo sapiens)
BIRC3  (baculoviral IAP repeat containing 3)


Additional Information