RGD Reference Report - Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis. - Rat Genome Database

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Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis.

Authors: Kawashita, Yoichiro  Morine, Yuji  Ikemoto, Tetsuya  Saito, Yu  Iwahashi, Syuichi  Yamada, Shinichiro  Higashijima, Jun  Imura, Satoru  Ogawa, Hirohisa  Yagi, Toshiyuki  Shimada, Mitsuo 
Citation: Kawashita Y, etal., J Hepatobiliary Pancreat Sci. 2017 Oct;24(10):576-583. doi: 10.1002/jhbp.500. Epub 2017 Oct 12.
RGD ID: 21408566
Pubmed: PMID:28846828   (View Abstract at PubMed)
DOI: DOI:10.1002/jhbp.500   (Journal Full-text)


BACKGROUND: Fbxw7 is a tumor suppressor through ubiquitination and degradation of multiple oncoproteins. Loss of Fbxw7 is frequently observed in various human cancers. In this study, we examined the role of Fbxw7 expression in colorectal liver metastasis (CRLM) and its mechanism.
METHODS: Fifty-six patients with CRLM who undergo curative resection were enrolled. Fbxw7 in tumor tissue was determined by immunohistochemistry. Patients were divided into two groups, the Fbxw7 high and low groups. Clinicopathological factors including miR-223 expression were compared between the high (n = 32) and low Fbxw7 groups (n = 24).
RESULTS: Fbxw7 expression in tumor tissues was significantly lower than that in normal tissues. The disease-free survival in the low Fbxw7 group was significantly worse than that in the high Fbxw7 group, and 3 years disease-free survival of the low and high Fbxw7 groups were 12.5% and 47.0%, respectively (P = 0.023). On multivariate analysis, loss of Fbxw7 was detected as one of the independent risk factors for recurrence of CRLM (hazard ratio: 2.390, P = 0.017). Likewise, Fbxw7 expression inversely correlated to miR-223 expression (P = 0.017).
CONCLUSION: Loss of Fbxw7 in tumor tissues could be a reliable predictor of recurrence after hepatectomy in patients with CRLM, and miR-223 might be a possible regulator of Fbxw7.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FBXW7HumanLiver Metastasis disease_progressionIEP associated with colorectal cancerRGD 
Fbxw7MouseLiver Metastasis disease_progressionISOFBXW7 (Homo sapiens)associated with colorectal cancerRGD 
Fbxw7RatLiver Metastasis disease_progressionISOFBXW7 (Homo sapiens)associated with colorectal cancerRGD 
MIR223HumanLiver Metastasis disease_progressionIEP associated with colorectal cancerRGD 
Mir223MouseLiver Metastasis disease_progressionISOMIR223 (Homo sapiens)associated with colorectal cancerRGD 
Mir223RatLiver Metastasis disease_progressionISOMIR223 (Homo sapiens)associated with colorectal cancerRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fbxw7  (F-box and WD repeat domain containing 7)
Mir223  (microRNA 223)

Genes (Mus musculus)
Fbxw7  (F-box and WD-40 domain protein 7)
Mir223  (microRNA 223)

Genes (Homo sapiens)
FBXW7  (F-box and WD repeat domain containing 7)
MIR223  (microRNA 223)


Additional Information