RGD Reference Report - SALL4 is a marker of the embryonal subtype of hepatoblastoma. - Rat Genome Database

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SALL4 is a marker of the embryonal subtype of hepatoblastoma.

Authors: Gnemmi, V  Leteurtre, E  Sudour-Bonnange, H  Devisme, L  Guettier, C  Buob, D  Leroy, X 
Citation: Gnemmi V, etal., Histopathology. 2013 Sep;63(3):425-8. doi: 10.1111/his.12187. Epub 2013 Jul 3.
RGD ID: 11556217
Pubmed: PMID:23822878   (View Abstract at PubMed)
DOI: DOI:10.1111/his.12187   (Journal Full-text)

AIMS: SALL4 is a marker of germ cell tumours. The aim of this study was to investigate SALL4 expression in blastemal tumours, particularly in hepatoblastoma. METHODS AND RESULTS: The study included 12 hepatoblastomas. Eight hepatoblastomas were pure epithelial tumours, and four were mixed epithelial and mesenchymal tumours. The patients were nine males and three females with a mean age of 14.6 months. Immunohistochemistry was performed with an antibody against SALL4, using an automated immunostainer. Seven of 12 hepatoblastomas showed nuclear staining only in the embryonal component. Fetal and mesenchymal components were negative. CONCLUSIONS: SALL4 is expressed in blastemal tumours, particularly in the embryonal subtype of hepatoblastoma. Pathologists need to be aware of such expression so that misdiagnosis can be avoided.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SALL1Humanhepatoblastoma  IEP embryonal subtype more ...RGD 
SALL4Humanhepatoblastoma  IEP Embryonal Hepatoblastoma and protein:increased expression:liver (human)RGD 
Sall1Rathepatoblastoma  ISOSALL1 (Homo sapiens)embryonal subtype more ...RGD 
Sall1Mousehepatoblastoma  ISOSALL1 (Homo sapiens)embryonal subtype more ...RGD 
Sall4Rathepatoblastoma  ISOSALL4 (Homo sapiens)Embryonal Hepatoblastoma and protein:increased expression:liver (human)RGD 
Sall4Mousehepatoblastoma  ISOSALL4 (Homo sapiens)Embryonal Hepatoblastoma and protein:increased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sall1  (spalt-like transcription factor 1)
Sall4  (spalt-like transcription factor 4)

Genes (Mus musculus)
Sall1  (spalt like transcription factor 1)
Sall4  (spalt like transcription factor 4)

Genes (Homo sapiens)
SALL1  (spalt like transcription factor 1)
SALL4  (spalt like transcription factor 4)


Additional Information