Advanced Search (OLGA)

Gene: Cd40lg (CD40 ligand) Heterocephalus glaber

Analyze

Symbol:

Cd40lg

Name:

CD40 ligand

RGD ID:

18936821

Description:

ENCODES a protein that exhibits CD40 receptor binding (ortholog); INVOLVED IN B cell differentiation (ortholog); cellular response to tumor necrosis factor (ortholog); dendritic cell differentiation (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; obesity pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Coronary Syndrome (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cell body (ortholog); cell projection (ortholog); cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CD40LG (CD40 ligand)	NCBI	Ortholog
Mus musculus (house mouse):	Cd40lg (CD40 ligand)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cd40lg (CD40 ligand)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cd40lg (CD40 ligand)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CD40LG (CD40 ligand)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CD40LG (CD40 ligand)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cd40lg (CD40 ligand)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CD40LG (CD40 ligand)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CD40LG (CD40 ligand)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624808	10,472,572 - 10,484,338 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624808	10,472,028 - 10,484,407 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acquired immunodeficiency syndrome (ISO)

Acute Coronary Syndrome (ISO)

acute lymphoblastic leukemia (ISO)

allergic disease (ISO)

allergic rhinitis (ISO)

Alzheimer's disease (ISO)

amyotrophic lateral sclerosis (ISO)

anti-basement membrane glomerulonephritis (ISO)

antiphospholipid syndrome (ISO)

aplastic anemia (ISO)

asthma (ISO)

atherosclerosis (ISO)

autistic disorder (ISO)

autoimmune disease (ISO)

autoimmune thrombocytopenic purpura (ISO)

autosomal hemophilia A (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

Behcet's disease (ISO)

Brain Injuries (ISO)

Calcification of Aortic Valve (ISO)

cardiovascular system disease (ISO)

carotid artery disease (ISO)

CD40 ligand deficiency (ISO)

Cholangiofibrosis (ISO)

Christianson syndrome (ISO)

Chromosome Breakage (ISO)

Chromosome Xq26.3 Duplication Syndrome (ISO)

Chronic Allograft Dysfunction (ISO)

chronic lymphocytic leukemia (ISO)

cocaine abuse (ISO)

Colonic Neoplasms (ISO)

combined T cell and B cell immunodeficiency (ISO)

common variable immunodeficiency (ISO)

Congenital Heart Defects, Multiple Types, 1, X-Linked (ISO)

congestive heart failure (ISO)

coronary artery disease (ISO)

Coronary Disease (ISO)

crescentic glomerulonephritis (ISO)

cutaneous lupus erythematosus (ISO)

cystic fibrosis (ISO)

dermatomyositis (ISO)

diabetes mellitus (ISO)

diabetic angiopathy (ISO)

Diabetic Nephropathies (ISO)

Discoid Lupus Erythematosus (ISO)

dysgammaglobulinemia (ISO)

Ehrlich tumor carcinoma (ISO)

end stage renal disease (ISO)

eosinophilic esophagitis (ISO)

erythema multiforme (ISO)

essential thrombocythemia (ISO)

Experimental Arthritis (ISO)

Experimental Autoimmune Myasthenia Gravis (ISO)

Experimental Autoimmune Neuritis (ISO)

Experimental Autoimmune Uveoretinitis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Neoplasms (ISO)

factor VIII deficiency (ISO)

familial hyperlipidemia (ISO)

Fibrosis (ISO)

follicular lymphoma (ISO)

genetic disease (ISO)

graft-versus-host disease (ISO)

granulomatosis with polyangiitis (ISO)

Graves' disease (ISO)

Hashimoto Disease (ISO)

HELLP syndrome (ISO)

hepatocellular carcinoma (ISO)

herpes simplex (ISO)

Hodgkin's lymphoma (ISO)

human immunodeficiency virus infectious disease (ISO)

Hypercholesterolemia (ISO)

inflammatory bowel disease (ISO)

Kawasaki disease (ISO)

kidney disease (ISO)

lichen planus (ISO)

lupus nephritis (ISO)

Lyme Neuroborreliosis (ISO)

malaria (ISO)

membranous glomerulonephritis (ISO)

Metabolic Syndrome (ISO)

Middle East respiratory syndrome (ISO)

migraine (ISO)

multiple myeloma (ISO)

Murine Acquired Immunodeficiency Syndrome (ISO)

myocardial infarction (ISO)

Myocardial Ischemia (ISO)

narcolepsy (ISO)

Necrosis (ISO)

nephrosis (ISO)

obesity (ISO)

ovarian disease (ISO)

Ovarian Neoplasms (ISO)

overactive bladder syndrome (ISO)

pemphigus (ISO)

Penetrating Wounds (ISO)

perinatal necrotizing enterocolitis (ISO)

periodontal disease (ISO)

periodontitis (ISO)

peritonitis (ISO)

pneumonia (ISO)

pre-eclampsia (ISO)

Primary Graft Dysfunction (ISO)

pulmonary hypertension (ISO)

Reperfusion Injury (ISO)

Sepsis (ISO)

Shock (ISO)

sickle cell anemia (ISO)

Sjogren's syndrome (ISO)

Subacute Combined Degeneration (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

systemic lupus erythematosus (ISO)

thrombocytopenia (ISO)

thrombosis (ISO)

tick-borne encephalitis (ISO)

transient cerebral ischemia (ISO)

Transplant Rejection (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

urinary bladder cancer (ISO)

Vascular Calcification (ISO)

Viral Myocarditis (ISO)

visceral leishmaniasis (ISO)

vitamin B12 deficiency (ISO)

X-linked Emery-Dreifuss muscular dystrophy 6 (ISO)

X-linked hyper IgM syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell differentiation (IEA,ISO)

B cell proliferation (IEA)

CD40 signaling pathway (IEA)

cellular response to tumor necrosis factor (ISO)

dendritic cell differentiation (ISO)

immune response (IEA)

inflammatory response (IEA)

integrin-mediated signaling pathway (IEA)

isotype switching (IEA)

negative regulation of apoptotic process (IEA)

platelet activation (IEA)

positive regulation of B cell proliferation (ISO)

positive regulation of dendritic cell differentiation (ISO)

positive regulation of endothelial cell apoptotic process (IEA)

positive regulation of gene expression (ISO)

positive regulation of immune response to tumor cell (ISO)

positive regulation of interleukin-10 production (IEA,ISO)

positive regulation of interleukin-12 production (IEA,ISO)

positive regulation of interleukin-4 production (IEA)

positive regulation of MHC class II biosynthetic process (ISO)

positive regulation of NF-kappaB transcription factor activity (ISO)

positive regulation of T cell proliferation (IEA)

positive regulation of type II interferon production (ISO)

regulation of immunoglobulin production (IEA,ISO)

response to cobalamin (ISO)

response to peptide (ISO)

Cellular Component

cell body (ISO)

cell projection (ISO)

cell surface (IEA,ISO)

external side of plasma membrane (IEA)

extracellular region (IEA)

extracellular space (IEA,ISO)

Golgi apparatus (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

CD40 receptor binding (IEA,ISO)

cytokine activity (IEA)

integrin binding (IEA)

protein binding (ISO)

protein serine/threonine kinase activator activity (IEA)

tumor necrosis factor receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-4 signaling pathway (ISO)

obesity pathway (ISO)

References

Additional References at PubMed

PMID:21993625	PMID:22301074

Genomics

Comparative Map Data

Cd40lg
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624808	10,472,572 - 10,484,338 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624808	10,472,028 - 10,484,407 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

CD40LG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	136,648,158 - 136,660,390 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	136,648,158 - 136,660,390 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	135,730,317 - 135,742,549 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	135,558,002 - 135,570,215 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	135,455,855 - 135,468,068	NCBI
Celera	X	136,094,012 - 136,106,224 (+)	NCBI		Celera
Cytogenetic Map	X	q26.3	NCBI
HuRef	X	125,001,305 - 125,013,640 (+)	NCBI		HuRef
CHM1_1	X	135,641,985 - 135,654,211 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	134,956,900 - 134,969,116 (+)	NCBI		T2T-CHM13v2.0

Cd40lg
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	56,257,448 - 56,269,402 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	56,257,503 - 56,269,402 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	57,212,143 - 57,224,042 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	57,212,143 - 57,224,042 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	54,465,320 - 54,477,219 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	53,558,927 - 53,570,826 (+)	NCBI		MGSCv36	mm8
Celera	X	43,689,623 - 43,701,548 (+)	NCBI		Celera
Cytogenetic Map	X	A6	NCBI
cM Map	X	31.21	NCBI

Cd40lg
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	140,164,341 - 140,176,057 (+)	NCBI		GRCr8
mRatBN7.2	X	135,127,052 - 135,138,768 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	135,126,969 - 135,138,306 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	137,323,952 - 137,335,135 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	140,881,620 - 140,892,805 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	138,451,019 - 138,462,204 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	159,703,703 - 159,714,886 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	159,703,578 - 159,716,562 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	154,330,893 - 154,341,954 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	141,925,019 - 141,937,183 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	141,998,451 - 142,010,616 (+)	NCBI
Celera	X	143,160,596 - 143,171,765 (+)	NCBI		Celera
Cytogenetic Map	X	q36	NCBI

Cd40lg
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955489	8,465,164 - 8,477,746 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955489	8,465,571 - 8,477,714 (-)	NCBI	ChiLan1.0	ChiLan1.0

CD40LG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	136,065,286 - 136,078,025 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	136,068,886 - 136,081,625 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	125,776,138 - 125,788,820 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	136,042,849 - 136,055,158 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	136,042,849 - 136,058,202 (+)	Ensembl	panpan1.1		panPan2

CD40LG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	107,001,421 - 107,023,007 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	107,010,890 - 107,023,006 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	92,832,126 - 92,844,241 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	108,980,873 - 109,002,662 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	108,990,551 - 109,002,661 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	106,131,221 - 106,143,392 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	108,322,638 - 108,334,748 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	107,964,432 - 107,976,548 (+)	NCBI		UU_Cfam_GSD_1.0

Cd40lg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	104,994,220 - 105,007,112 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936513	10,607,617 - 10,620,403 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936513	10,607,617 - 10,620,403 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CD40LG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	111,778,493 - 111,789,709 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	111,778,666 - 111,788,901 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	127,636,797 - 127,647,035 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CD40LG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	111,655,301 - 111,667,602 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	111,655,397 - 111,666,639 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	49,341,810 - 49,354,077 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004862331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01074340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JH166132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000004709 ⟹ ENSHGLP00000004647

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624808	10,472,572 - 10,484,338 (-)	Ensembl

RefSeq Acc Id:

XM_004862331 ⟹ XP_004862388

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624808	10,472,028 - 10,484,407 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_004862388	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EHA98515	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000004647
	ENSHGLP00000046511
	ENSHGLP00100060241

RefSeq Acc Id:	XP_004862388 ⟸ XM_004862331
- UniProtKB:	G5ANA5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000004647 ⟸ ENSHGLT00000004709

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000003399	Ensembl, ENTREZGENE
	ENSHGLG00000046347	UniProtKB/TrEMBL
	ENSHGLG00100051381	UniProtKB/TrEMBL
Ensembl Transcript	ENSHGLT00000004709	ENTREZGENE
	ENSHGLT00000065577	UniProtKB/TrEMBL
	ENSHGLT00100054065	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.40	UniProtKB/TrEMBL
InterPro	CD40L	UniProtKB/TrEMBL
	TNF_CS	UniProtKB/TrEMBL
	TNF_dom	UniProtKB/TrEMBL
	Tumour_necrosis_fac-like_dom	UniProtKB/TrEMBL
KEGG Report	hgl:101700616	UniProtKB/TrEMBL
NCBI Gene	Cd40lg	ENTREZGENE
PANTHER	PTHR11471:SF5	UniProtKB/TrEMBL
	TUMOR NECROSIS FACTOR FAMILY MEMBER	UniProtKB/TrEMBL
Pfam	TNF	UniProtKB/TrEMBL
PIRSF	TNF_5	UniProtKB/TrEMBL
PRINTS	CD40LIGAND	UniProtKB/TrEMBL
PROSITE	TNF_1	UniProtKB/TrEMBL
	TNF_2	UniProtKB/TrEMBL
SMART	TNF	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49842	UniProtKB/TrEMBL
UniProt	G5ANA5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)