Dnmt3a (DNA methyltransferase 3 alpha) - Rat Genome Database

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Gene: Dnmt3a (DNA methyltransferase 3 alpha) Heterocephalus glaber
Analyze
Symbol: Dnmt3a
Name: DNA methyltransferase 3 alpha
RGD ID: 18906181
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); identical protein binding (ortholog); INVOLVED IN autosome genomic imprinting (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); PARTICIPATES IN DNA modification pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute monocytic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN catalytic complex (ortholog); chromosome, centromeric region (ortholog); euchromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA (cytosine-5)-methyltransferase 3A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,485,842 - 7,581,056 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247387,481,084 - 7,581,332 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute monocytic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
amyotrophic lateral sclerosis  (ISO)
autism spectrum disorder  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bone marrow disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital heart disease  (ISO)
Craniofacial Abnormalities  (ISO)
Crohn's disease  (ISO)
depressive disorder  (ISO)
diffuse large B-cell lymphoma  (ISO)
Dwarfism  (ISO)
endometriosis  (ISO)
endometriosis of uterus  (ISO)
Facies  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Growth Disorders  (ISO)
hepatocellular carcinoma  (ISO)
Heyn-Sproul-Jackson Syndrome  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
intellectual disability  (ISO)
juvenile myelomonocytic leukemia  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
melanoma  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
Muscle Hypotonia  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (ISO)
Neoplasm Recurrence, Local  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
peripheral T-cell lymphoma  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prostate adenocarcinoma  (ISO)
prostatitis  (ISO)
sciatic neuropathy  (ISO)
Sezary's disease  (ISO)
stomach cancer  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
Tatton-Brown-Rahman syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Dnmt3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,485,842 - 7,581,056 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247387,481,084 - 7,581,332 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DNMT3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38225,227,874 - 25,342,590 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl225,227,855 - 25,342,590 (-)EnsemblGRCh38hg38GRCh38
GRCh37225,450,743 - 25,565,459 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,309,349 - 25,418,963 (-)NCBINCBI36Build 36hg18NCBI36
Celera225,296,144 - 25,405,816 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,193,733 - 25,302,862 (-)NCBIHuRef
CHM1_1225,385,740 - 25,495,369 (-)NCBICHM1_1
T2T-CHM13v2.0225,263,222 - 25,377,928 (-)NCBIT2T-CHM13v2.0
Dnmt3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39123,851,559 - 3,964,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl123,856,007 - 3,964,443 (+)EnsemblGRCm39 Ensembl
GRCm38123,801,559 - 3,914,443 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,806,007 - 3,914,443 (+)EnsemblGRCm38mm10GRCm38
MGSCv37123,806,980 - 3,914,443 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36123,835,027 - 3,914,455 (+)NCBIMGSCv36mm8
Celera123,763,156 - 3,842,112 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
Dnmt3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,507,316 - 32,621,678 (+)NCBIGRCr8
mRatBN7.2626,791,517 - 26,902,161 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,822,609 - 26,896,687 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx627,114,932 - 27,188,991 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,430,833 - 27,504,894 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,909,402 - 26,983,738 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,205,375 - 28,346,052 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,235,695 - 28,340,577 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,044,960 - 38,082,583 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0638,132,683 - 38,149,613 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,802,612 - 26,878,878 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,805,564 - 26,881,831 (+)NCBI
Celera626,297,300 - 26,371,904 (+)NCBICelera
Cytogenetic Map6q14NCBI
Dnmt3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,269,952 - 7,367,059 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554697,264,431 - 7,367,059 (-)NCBIChiLan1.0ChiLan1.0
DNMT3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,173,664 - 101,289,206 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,177,630 - 101,288,083 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A25,229,593 - 25,344,733 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A25,331,095 - 25,441,785 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A25,331,095 - 25,412,605 (-)Ensemblpanpan1.1panPan2
DNMT3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,489,524 - 19,563,074 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,492,193 - 19,563,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1719,382,990 - 19,486,679 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01719,761,597 - 19,865,311 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,767,351 - 19,865,307 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,495,608 - 19,599,241 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,505,342 - 19,609,205 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,551,811 - 19,655,519 (-)NCBIUU_Cfam_GSD_1.0
Dnmt3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,826,309 - 63,930,744 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,935,386 - 7,007,610 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,963,406 - 7,013,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,528,926 - 113,603,087 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13113,501,972 - 113,609,148 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23120,579,692 - 120,663,698 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,313,414 - 82,427,170 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,402,826 - 82,420,819 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604529,732,050 - 29,846,532 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000021049   ⟹   ENSHGLP00000020846
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247387,485,842 - 7,581,056 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000021050   ⟹   ENSHGLP00000020847
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247387,485,842 - 7,502,686 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000021051   ⟹   ENSHGLP00000020848
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247387,486,536 - 7,488,072 (-)Ensembl
RefSeq Acc Id: XM_004839112   ⟹   XP_004839169
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247387,481,084 - 7,580,420 (-)NCBI
RefSeq Acc Id: XM_004839113   ⟹   XP_004839170
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247387,481,084 - 7,580,990 (-)NCBI
RefSeq Acc Id: XM_004839114   ⟹   XP_004839171
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247387,481,084 - 7,581,332 (-)NCBI
RefSeq Acc Id: XM_004839115   ⟹   XP_004839172
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247387,481,084 - 7,554,287 (-)NCBI
RefSeq Acc Id: XM_004839117   ⟹   XP_004839174
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247387,481,084 - 7,502,777 (-)NCBI
RefSeq Acc Id: XM_021253567   ⟹   XP_021109226
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247387,481,084 - 7,561,040 (-)NCBI
RefSeq Acc Id: XM_021253568   ⟹   XP_021109227
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247387,481,084 - 7,545,890 (-)NCBI
RefSeq Acc Id: XM_021253569   ⟹   XP_021109228
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247387,481,084 - 7,502,547 (-)NCBI
RefSeq Acc Id: XM_021253570   ⟹   XP_021109229
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247387,481,084 - 7,502,546 (-)NCBI
RefSeq Acc Id: XM_021253571   ⟹   XP_021109230
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247387,481,084 - 7,501,072 (-)NCBI
RefSeq Acc Id: XP_004839171   ⟸   XM_004839114
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J1T9 (UniProtKB/TrEMBL),   G5CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004839170   ⟸   XM_004839113
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J1T9 (UniProtKB/TrEMBL),   G5CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004839169   ⟸   XM_004839112
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J1T9 (UniProtKB/TrEMBL),   G5CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109226   ⟸   XM_021253567
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J1T9 (UniProtKB/TrEMBL),   G5CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004839172   ⟸   XM_004839115
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J1T9 (UniProtKB/TrEMBL),   G5CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109227   ⟸   XM_021253568
- Peptide Label: isoform X2
- UniProtKB: A0AAX6SHD9 (UniProtKB/TrEMBL),   G5CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004839174   ⟸   XM_004839117
- Peptide Label: isoform X3
- UniProtKB: A0AAX6NXH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109228   ⟸   XM_021253569
- Peptide Label: isoform X3
- UniProtKB: A0AAX6NXH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109229   ⟸   XM_021253570
- Peptide Label: isoform X3
- UniProtKB: A0AAX6NXH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109230   ⟸   XM_021253571
- Peptide Label: isoform X3
- UniProtKB: A0AAX6NXH7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000020846   ⟸   ENSHGLT00000021049
Ensembl Acc Id: ENSHGLP00000020848   ⟸   ENSHGLT00000021051
Ensembl Acc Id: ENSHGLP00000020847   ⟸   ENSHGLT00000021050


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014901 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000021049 ENTREZGENE
  ENSHGLT00000021050 ENTREZGENE
Gene3D-CATH 2.30.30.140 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
  PWWP, helical domain UniProtKB/TrEMBL
InterPro ADD UniProtKB/TrEMBL
  ADD_DNMT3A UniProtKB/TrEMBL
  C5_DNA_meth_AS UniProtKB/TrEMBL
  C5_MeTfrase UniProtKB/TrEMBL
  DNM3A_N UniProtKB/TrEMBL
  DNMT3_ADD UniProtKB/TrEMBL
  DNMT3_ADD_PHD UniProtKB/TrEMBL
  PWWP_dom UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
KEGG Report hgl:101718745 UniProtKB/TrEMBL
NCBI Gene Dnmt3a ENTREZGENE
PANTHER DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED UniProtKB/TrEMBL
  PTHR23068:SF10 UniProtKB/TrEMBL
Pfam ADD_DNMT3 UniProtKB/TrEMBL
  ADDz_Dnmt3b UniProtKB/TrEMBL
  DNA_methylase UniProtKB/TrEMBL
  DNM3A_N UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
PROSITE ADD UniProtKB/TrEMBL
  C5_MTASE_1 UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SAM_MT_C5 UniProtKB/TrEMBL
SMART PWWP UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A0P6J1T9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6NXH7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SHD9 ENTREZGENE, UniProtKB/TrEMBL
  G5CBL5 ENTREZGENE, UniProtKB/TrEMBL