Rps6ka3 (ribosomal protein S6 kinase A3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Rps6ka3 (ribosomal protein S6 kinase A3) Heterocephalus glaber
Analyze
Symbol: Rps6ka3
Name: ribosomal protein S6 kinase A3
RGD ID: 18905394
Description: ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); response to lipopolysaccharide (ortholog); toll-like receptor signaling pathway (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); bone development disease (ortholog); Coffin-Lowry syndrome (ortholog); FOUND IN cytosol (ortholog); nucleolus (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ribosomal protein S6 kinase alpha-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248294,983,282 - 5,087,485 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248294,978,181 - 5,087,493 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rps6ka3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248294,983,282 - 5,087,485 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248294,978,181 - 5,087,493 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RPS6KA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X20,149,911 - 20,267,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX20,149,911 - 20,267,519 (-)EnsemblGRCh38hg38GRCh38
GRCh37X20,168,029 - 20,285,027 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X20,077,950 - 20,194,671 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X19,927,686 - 20,044,407NCBI
CeleraX24,292,410 - 24,377,495 (-)NCBICelera
Cytogenetic MapXp22.12NCBI
HuRefX17,910,375 - 17,994,979 (-)NCBIHuRef
CHM1_1X20,198,431 - 20,315,161 (-)NCBICHM1_1
T2T-CHM13v2.0X19,732,804 - 19,849,991 (-)NCBIT2T-CHM13v2.0
Rps6ka3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X158,038,652 - 158,151,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX157,993,303 - 158,151,240 (+)EnsemblGRCm39 Ensembl
GRCm38X159,255,665 - 159,368,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX159,210,307 - 159,368,244 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X155,694,052 - 155,801,417 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X154,600,225 - 154,707,590 (+)NCBIMGSCv36mm8
CeleraX142,502,588 - 142,610,345 (+)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX73.27NCBI
Rps6ka3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X39,325,926 - 39,432,017 (-)NCBIGRCr8
mRatBN7.2X35,517,306 - 35,623,296 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX35,517,306 - 35,623,207 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX36,654,891 - 36,760,704 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X40,118,536 - 40,224,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X35,284,577 - 35,390,389 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X37,469,736 - 37,576,055 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX37,469,937 - 37,575,624 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X37,777,188 - 37,880,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X56,722,878 - 56,825,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX36,172,781 - 36,274,458 (-)NCBICelera
Cytogenetic MapXq14NCBI
Rps6ka3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955509600,284 - 701,837 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955509600,415 - 701,833 (-)NCBIChiLan1.0ChiLan1.0
RPS6KA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X21,950,359 - 22,071,084 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X21,953,743 - 22,074,469 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X12,772,368 - 12,893,062 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X20,131,474 - 20,251,244 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX20,133,898 - 20,251,244 (-)Ensemblpanpan1.1panPan2
RPS6KA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X15,991,623 - 16,079,689 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX15,998,172 - 16,074,749 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X16,014,242 - 16,126,834 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX16,018,291 - 16,223,711 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X16,063,855 - 16,176,430 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X16,071,626 - 16,184,200 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X16,133,724 - 16,246,281 (-)NCBIUU_Cfam_GSD_1.0
Rps6ka3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X9,152,237 - 9,260,014 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366243,897,791 - 4,000,558 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366243,897,878 - 4,005,664 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX16,452,405 - 16,576,859 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X16,452,401 - 16,576,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X17,719,536 - 17,833,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X18,614,664 - 18,730,591 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX18,620,159 - 18,730,581 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605620,472,991 - 20,589,270 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000001884   ⟹   ENSHGLP00000001838
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248294,983,282 - 5,087,485 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000001885   ⟹   ENSHGLP00000001839
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248294,983,282 - 5,087,458 (-)Ensembl
RefSeq Acc Id: XM_004866175   ⟹   XP_004866232
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248294,978,181 - 5,087,493 (-)NCBI
RefSeq Acc Id: XM_004866177   ⟹   XP_004866234
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248294,978,181 - 5,087,467 (-)NCBI
RefSeq Acc Id: XM_004866178   ⟹   XP_004866235
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248294,978,181 - 5,087,464 (-)NCBI
RefSeq Acc Id: XM_004866179   ⟹   XP_004866236
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248294,978,181 - 5,087,466 (-)NCBI
RefSeq Acc Id: XM_004866181   ⟹   XP_004866238
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248294,978,181 - 5,037,590 (-)NCBI
RefSeq Acc Id: XM_021245370   ⟹   XP_021101029
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248294,978,181 - 5,087,493 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004866232   ⟸   XM_004866175
- Peptide Label: isoform X1
- UniProtKB: G5B3X2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021101029   ⟸   XM_021245370
- Peptide Label: isoform X2
- UniProtKB: G5B3X2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004866234   ⟸   XM_004866177
- Peptide Label: isoform X2
- UniProtKB: G5B3X2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004866236   ⟸   XM_004866179
- Peptide Label: isoform X2
- UniProtKB: G5B3X2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004866235   ⟸   XM_004866178
- Peptide Label: isoform X2
- UniProtKB: G5B3X2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004866238   ⟸   XM_004866181
- Peptide Label: isoform X3
- UniProtKB: G5B3X2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000001838   ⟸   ENSHGLT00000001884
RefSeq Acc Id: ENSHGLP00000001839   ⟸   ENSHGLT00000001885


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001399 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000001884 ENTREZGENE
  ENSHGLT00000001885 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ribosomal_S6_kinase_II UniProtKB/TrEMBL
  RPS6KA3_C UniProtKB/TrEMBL
  RSK_N UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Rps6ka3 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF Ribsml_S6_kin_2 UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt G5B3X2 ENTREZGENE, UniProtKB/TrEMBL