RGD Reference Report - Low expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci induced in rat liver by diethylnitrosamine or phenobarbital. - Rat Genome Database

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Low expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci induced in rat liver by diethylnitrosamine or phenobarbital.

Authors: Martens, U  Lennartsson, P  Hogberg, J  Stenius, U 
Citation: Martens U, etal., Cancer Lett. 1996 Jun 24;104(1):21-6.
RGD ID: 8662309
Pubmed: PMID:8640740   (View Abstract at PubMed)

The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79% of the EAF induced by PB were p21-negative. The proportion of p21-negative EAF increased with the size of the foci and more than 90% of the largest EAF were p21-negative. p21 is a mediator of p53 signals leading to block of the cell cycle. In conjunction with previous data indicating that p53 is not induced in GST-P-positive hepatocytes isolated from EAF-bearing rats, the results of this study suggest a role for altered signaling in the G1-S check point in rat hepatocarcinogenesis.




  
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Term
Qualifier
Evidence
With
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Original Reference(s)
CDKN1AHumanExperimental Liver Neoplasms  ISOCdkn1a (Rattus norvegicus)protein:decreased expression:liver:RGD 
Cdkn1aRatExperimental Liver Neoplasms  IEP protein:decreased expression:liver:RGD 
Cdkn1aMouseExperimental Liver Neoplasms  ISOCdkn1a (Rattus norvegicus)protein:decreased expression:liver:RGD 


Genes (Rattus norvegicus)
Cdkn1a  (cyclin-dependent kinase inhibitor 1A)

Genes (Mus musculus)
Cdkn1a  (cyclin dependent kinase inhibitor 1A)

Genes (Homo sapiens)
CDKN1A  (cyclin dependent kinase inhibitor 1A)