Cdkn2b (cyclin dependent kinase inhibitor 2B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cdkn2b (cyclin dependent kinase inhibitor 2B) Heterocephalus glaber
Analyze
Symbol: Cdkn2b
Name: cyclin dependent kinase inhibitor 2B
RGD ID: 18901290
Description: ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase inhibitor activity (inferred); kinase activity (inferred); protein kinase binding (inferred); INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); cellular senescence (ortholog); liver development (ortholog); PARTICIPATES IN G1/S transition pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); acute myelomonocytic leukemia (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclin-dependent kinase 4 inhibitor B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473625,926,668 - 25,933,440 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473625,929,314 - 25,933,318 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Cdkn2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473625,926,668 - 25,933,440 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473625,929,314 - 25,933,318 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CDKN2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38922,002,903 - 22,009,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl922,002,903 - 22,009,305 (-)EnsemblGRCh38hg38GRCh38
GRCh37922,002,902 - 22,009,312 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,992,902 - 21,999,312 (-)NCBINCBI36Build 36hg18NCBI36
Build 34921,992,902 - 21,999,312NCBI
Celera921,941,270 - 21,947,682 (-)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef921,966,171 - 21,972,582 (-)NCBIHuRef
CHM1_1922,002,731 - 22,009,141 (-)NCBICHM1_1
T2T-CHM13v2.0922,017,276 - 22,023,690 (-)NCBIT2T-CHM13v2.0
Cdkn2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39489,224,526 - 89,229,269 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl489,224,536 - 89,229,276 (-)EnsemblGRCm39 Ensembl
GRCm38489,306,289 - 89,311,032 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl489,306,299 - 89,311,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv37488,952,198 - 88,956,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36488,777,556 - 88,782,190 (-)NCBIMGSCv36mm8
Celera487,792,244 - 87,797,039 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map442.15NCBI
Cdkn2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85109,123,308 - 109,134,906 (-)NCBIGRCr8
mRatBN7.25104,009,839 - 104,019,082 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5104,010,680 - 104,019,050 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5106,447,506 - 106,453,182 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05108,177,120 - 108,182,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05108,257,644 - 108,263,335 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05107,834,353 - 107,857,428 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5107,845,951 - 107,858,104 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05111,817,188 - 111,826,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45108,939,669 - 108,945,293 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15108,946,492 - 108,950,551 (-)NCBI
Celera5102,728,741 - 102,734,427 (-)NCBICelera
Cytogenetic Map5q32NCBI
Cdkn2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547212,275,544 - 12,280,528 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547212,275,613 - 12,280,141 (+)NCBIChiLan1.0ChiLan1.0
CDKN2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211102,545,185 - 102,554,222 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19102,550,897 - 102,560,167 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0921,838,902 - 21,845,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1922,455,662 - 22,462,156 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl922,455,662 - 22,462,156 (-)Ensemblpanpan1.1panPan2
CDKN2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11141,259,627 - 41,264,832 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1139,933,406 - 39,936,568 (-)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha1139,895,530 - 39,924,805 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01142,165,720 - 42,207,150 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1142,165,719 - 42,206,773 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11140,873,681 - 40,876,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01140,723,758 - 40,752,953 (-)NCBIUNSW_CanFamBas_1.0
UNSW_CanFamBas_1.01140,761,542 - 40,764,705 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01141,374,892 - 41,378,057 (-)NCBIUU_Cfam_GSD_1.0
Cdkn2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947155,907,481 - 155,911,659 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366523,538,986 - 3,581,159 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366523,576,975 - 3,582,790 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1200,761,004 - 200,766,056 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11200,666,250 - 200,770,880 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,955,554 - 223,960,641 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000015645   ⟹   ENSHGLP00000015483
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473625,926,668 - 25,933,440 (-)Ensembl
RefSeq Acc Id: XM_004838351   ⟹   XP_004838408
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473625,929,314 - 25,933,318 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004838408 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB06134 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000015483
  ENSHGLP00000046588
  ENSHGLP00100046873
GenBank Protein JAO02316 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004838408   ⟸   XM_004838351
- UniProtKB: A0A0P6JFE2 (UniProtKB/TrEMBL),   G5BA23 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000015483   ⟸   ENSHGLT00000015645


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011070 Ensembl, ENTREZGENE
  ENSHGLG00000038311 UniProtKB/TrEMBL
  ENSHGLG00100048638 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000015645 ENTREZGENE
  ENSHGLT00000054011 UniProtKB/TrEMBL
  ENSHGLT00100064402 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ank_Repeat/CDKN_Inhibitor UniProtKB/TrEMBL
  Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
KEGG Report hgl:101701062 UniProtKB/TrEMBL
NCBI Gene Cdkn2b ENTREZGENE
PANTHER ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 4 INHIBITOR B UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
PROSITE ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A0P6JFE2 ENTREZGENE, UniProtKB/TrEMBL
  G5BA23 ENTREZGENE, UniProtKB/TrEMBL