RGD Reference Report - Epigenetic alterations of p15(INK4B) and p16(INK4A) genes in pediatric primary myelodysplastic syndrome. - Rat Genome Database

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Epigenetic alterations of p15(INK4B) and p16(INK4A) genes in pediatric primary myelodysplastic syndrome.

Authors: Rodrigues, EF  Santos-Reboucas, CB  Goncalves Pimentel, MM  Mencalha, AL  Dobbin, J  Da Costa, ES  Fernandez Cde, S  Bouzas, LF  Abdelhay, E  De Souza Fernandez, T 
Citation: Rodrigues EF, etal., Leuk Lymphoma. 2010 Oct;51(10):1887-94. doi: 10.3109/10428194.2010.505820.
RGD ID: 11251750
Pubmed: PMID:20658957   (View Abstract at PubMed)
DOI: DOI:10.3109/10428194.2010.505820   (Journal Full-text)

We studied the methylation status of the p15(INK4B) and p16(INK4A) genes in 47 pediatric patients with primary MDS, its correlation with subtype, and the role of p15(INK4B) and p16(INK4A) in the evolution of MDS toward AML. Aberrant methylation of the p15(INK4B) gene was detected in 15 of 47 patients (32%), whereas only four patients demonstrated methylation of the p16(INK4A) gene (8%). The frequency of p15(INK4B) methylation was significantly higher in RAEB and RAEB-t subtypes (p<0.003). Aberrant methylation of the p16(INK4A) gene was also more frequent in the subtypes that characterize advanced stages of the disease (p<0.05). Evolution of disease was verified in 17 (36%) of the 47 patients. The association of p15(INK4B) and p16(INK4A) methylation status with evolution of disease was clearly significant (p<0.008 and p<0.05, respectively). These results suggest that methylation of the p15(INK4B) and p16(INK4A) genes is an epigenetic biomarker of pediatric disease evolution.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CDKN2AHumanmyelodysplastic syndrome severityIDA DNA:hypermethylation: :RGD 
CDKN2BHumanmyelodysplastic syndrome  IDA DNA:altered methylation: :RGD 
Cdkn2aRatmyelodysplastic syndrome severityISOCDKN2A (Homo sapiens)DNA:hypermethylation: :RGD 
Cdkn2aMousemyelodysplastic syndrome severityISOCDKN2A (Homo sapiens)DNA:hypermethylation: :RGD 
Cdkn2bRatmyelodysplastic syndrome  ISOCDKN2B (Homo sapiens)DNA:altered methylation: :RGD 
Cdkn2bMousemyelodysplastic syndrome  ISOCDKN2B (Homo sapiens)DNA:altered methylation: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn2a  (cyclin-dependent kinase inhibitor 2A)
Cdkn2b  (cyclin-dependent kinase inhibitor 2B)

Genes (Mus musculus)
Cdkn2a  (cyclin dependent kinase inhibitor 2A)
Cdkn2b  (cyclin dependent kinase inhibitor 2B)

Genes (Homo sapiens)
CDKN2A  (cyclin dependent kinase inhibitor 2A)
CDKN2B  (cyclin dependent kinase inhibitor 2B)

Objects referenced in this article
Gene Cdkn2a_v1 cyclin-dependent kinase inhibitor 2A, variant 1 Rattus norvegicus

Additional Information