Cdkn2a_v1 (cyclin-dependent kinase inhibitor 2A, variant 1) - Rat Genome Database

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Gene: Cdkn2a_v1 (cyclin-dependent kinase inhibitor 2A, variant 1) Rattus norvegicus
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Symbol: Cdkn2a_v1
Name: cyclin-dependent kinase inhibitor 2A, variant 1
RGD ID: 1578733
Description: transcript variant of Cdkn2a which is transcribed from an alternative promoter using the 1alpha exon; involved in cell cycle regulation and tumorigenesis through interactions with Cdk4
INVOLVED IN aging; neurogenesis; response to caloric restriction; ASSOCIATED WITH hepatocellular carcinoma; acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN nucleus
Type: splice  of Cdkn2a  
Also known as: cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16 inhibits CDK4); Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; INK4A; MTS1; p16; p16 cyclin dependent kinase inhibitor 2a; p16Cdkn2a
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map5q32NCBI


References

References - curated
1. Abe M, etal., Jpn J Cancer Res 2002 Oct;93(10):1100-6.
2. Askari M, etal., Mol Biol Rep. 2013 Aug;40(8):4921-8. doi: 10.1007/s11033-013-2592-5. Epub 2013 May 28.
3. Bagnyukova TV, etal., Carcinogenesis. 2008 Jan 19;.
4. Belinsky SA, etal., Carcinogenesis 2002 Feb;23(2):335-9.
5. Buchynska LG and Nesina IP, Exp Oncol. 2006 Jun;28(2):152-5.
6. Chien WW, etal., Leuk Res. 2015 Apr;39(4):453-61. doi: 10.1016/j.leukres.2015.01.008. Epub 2015 Jan 25.
7. Cividin M, etal., Leuk Res. 2006 Oct;30(10):1273-8. Epub 2006 Mar 14.
8. de Koning MN, etal., Mod Pathol. 2008 Jan 11;.
9. Debies MT, etal., J Clin Invest. 2008 Jan;118(1):51-63.
10. Fasseu M, etal., Blood. 2007 Oct 1;110(7):2610-9. Epub 2007 May 16.
11. Focchi GR, etal., J Low Genit Tract Dis. 2007 Apr;11(2):98-104.
12. Geradts J and Wilson PA, Am J Pathol. 1996 Jul;149(1):15-20.
13. Heidenreich A, etal., J Urol. 1998 May;159(5):1725-30.
14. Hiroyasu M, etal., Am J Pathol 2002 Feb;160(2):419-24.
15. Hung KS, etal., Biochem Biophys Res Commun. 2000 Mar 24;269(3):718-25.
16. Kasahara T, etal., Anticancer Res. 2006 Nov-Dec;26(6B):4299-305.
17. Kawamoto K, etal., Biochem Biophys Res Commun. 2006 Jan 20;339(3):790-6. Epub 2005 Nov 22.
18. Kozlova EN and Lukanidin E, Glia 2002 Mar 15;37(4):337-48.
19. Krishnamurthy J, etal., J Clin Invest 2004 Nov;114(9):1299-307.
20. Laes J, etal., Cancer Genet Cytogenet 2000 Mar;117(2):118-24.
21. Lau WM, etal., Oncogene. 2007 Sep 6;26(41):6050-60. Epub 2007 Mar 19.
22. Louhelainen M, etal., J Physiol Pharmacol. 2009 Sep;60(3):41-7.
23. Monsonego J, etal., Acta Cytol. 2007 Sep-Oct;51(5):755-66.
24. Morey SR, etal., Cancer Res. 2006 Dec 15;66(24):11659-67.
25. Nagao M, etal., J Cell Biol. 2008 Dec 29;183(7):1243-57. doi: 10.1083/jcb.200807130.
26. Natrajan R, etal., J Clin Pathol. 2008 Jan;61(1):95-102. Epub 2007 Mar 16.
27. Nogueira MC, etal., Pathol Oncol Res. 2006;12(3):153-7. Epub 2006 Sep 23.
28. Pascale RM, etal., Hepatology. 2005 Dec;42(6):1310-9.
29. Quelle DE, etal., Cell 1995 Dec 15;83(6):993-1000.
30. RGD automated data pipeline
31. Rodrigues EF, etal., Leuk Lymphoma. 2010 Oct;51(10):1887-94. doi: 10.3109/10428194.2010.505820.
32. Romanenko A, etal., Virchows Arch. 2004 Sep;445(3):298-304. Epub 2004 Jul 1.
33. Shank-Calvo JA, etal., Oncogene. 2006 May 18;25(21):3023-31.
34. Sharma G, etal., Life Sci. 2007 Apr 24;80(20):1873-81. Epub 2007 Feb 27.
35. Swafford DS, etal., Mol Cell Biol 1997 Mar;17(3):1366-74.
36. Tanaka H, etal., Nephron Physiol 2005;101(2):p27-34. Epub 2005 Jun 30.
37. Toncheva D and Zaharieva B, Tumour Biol. 2005 Mar-Apr;26(2):88-93. Epub 2005 May 13.
38. Tschan MP, etal., Leuk Lymphoma. 2001 Sep-Oct;42(5):1077-87.
39. Yao Q, etal., Zhonghua Nan Ke Xue. 2006 Jan;12(1):28-31.
40. Zhang Z, etal., Mod Pathol. 2006 Oct;19(10):1339-43. Epub 2006 Jun 23.
41. Zheng S, etal., Epigenetics. 2012 Feb;7(2):183-90. doi: 10.4161/epi.7.2.18972.

Genomics


Expression


Sequence



Additional Information

Database Acc Id Source(s)
NCBI Gene Cdkn2a_v1


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-26 Cdkn2a_v1  cyclin-dependent kinase inhibitor 2A, variant 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein use of alternative promoters and alternative first exons for variant 1 (Cdkn2a) and variant 2 (p19Arf), both of which contain translation start sites, results in the production of two non-homologous proteins despite the fact that the transcripts share two downstream exons (exons 2 and 3)