CDKN2A (cyclin dependent kinase inhibitor 2A)

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Gene: CDKN2A (cyclin dependent kinase inhibitor 2A) Homo sapiens

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Symbol:

CDKN2A

Name:

cyclin dependent kinase inhibitor 2A

RGD ID:

737039

HGNC Page

HGNC

Description:

Exhibits several functions, including MDM2/MDM4 family protein binding activity; NF-kappaB binding activity; and enzyme inhibitor activity. Involved in several processes, including regulation of cellular protein localization; regulation of cellular protein metabolic process; and regulation of nucleobase-containing compound metabolic process. Localizes to several cellular components, including mitochondrion; nuclear lumen; and senescence-associated heterochromatin focus. Colocalizes with nuclear body. Implicated in several diseases, including breast cancer (multiple); hematologic cancer (multiple); melanoma (multiple); nervous system cancer (multiple); and pancreatic cancer (multiple). Biomarker of several diseases, including hepatobiliary system cancer (multiple); in situ carcinoma (multiple); leukemia (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple).

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

alternative reading frame; ARF; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; cell cycle negative regulator beta; CMM2; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A, isoform 4; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor p16; INK4; INK4a; MLM; MTS-1; MTS1; multiple tumor suppressor 1; P14; p14ARF; P16; p16-INK4; P16-INK4A; p16INK4; p16INK4a; P19; p19Arf; TP16

RGD Orthologs

Mouse

Rat

Bonobo

Pig

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	9	21,967,752 - 21,995,301 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	9	21,967,753 - 21,995,301 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	9	21,967,752 - 21,995,324 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	9	21,967,751 - 21,995,323 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	21,957,751 - 21,984,490 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	9	21,957,751 - 21,984,490	NCBI
Celera	9	21,906,103 - 21,932,858 (-)	NCBI
Cytogenetic Map	9	p21.3	NCBI
HuRef	9	21,930,969 - 21,957,759 (-)	NCBI		HuRef
CHM1_1	9	21,967,646 - 21,994,319 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM