Wnt2 (Wnt family member 2) - Rat Genome Database

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Gene: Wnt2 (Wnt family member 2) Heterocephalus glaber
Analyze
Symbol: Wnt2
Name: Wnt family member 2
RGD ID: 18929442
Description: ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN atrial cardiac muscle tissue morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); cardiac epithelial to mesenchymal transition (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); breast carcinoma (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Protein Wnt-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248272,045,595 - 2,089,442 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248272,045,733 - 2,088,284 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt2Naked Mole-Ratbreast cancer  ISOWNT2 (Homo sapiens)9068941mRNA:increased expression:breastRGDPMID:15736421 and REF_RGD_ID:2291874
Wnt2Naked Mole-Ratbreast carcinoma disease_progressionISOWNT2 (Homo sapiens)9068941DNA:amplification:breastRGDPMID:7903963 and REF_RGD_ID:2291879
Wnt2Naked Mole-Ratendometrial carcinoma  ISOWNT2 (Homo sapiens)9068941mRNA:decreased expression:endometriumRGDPMID:9099960 and REF_RGD_ID:2291875
Wnt2Naked Mole-RatExperimental Mammary Neoplasms  ISOWNT2 (Homo sapiens)9068941in vitro transformation of transfected C57MG mammary epithelial cell lineRGDPMID:8065359 more ...
Wnt2Naked Mole-RatExperimental Seizures  ISOWnt2 (Rattus norvegicus)9068941mRNA:increased expression:hippocampusRGDPMID:14625142 and REF_RGD_ID:2326231
Wnt2Naked Mole-RatFibroadenoma  ISOWNT2 (Homo sapiens)9068941mRNA:increased expression:breastRGDPMID:8168088 and REF_RGD_ID:2291878
Wnt2Naked Mole-Rathepatocellular carcinoma susceptibilityISOWNT2 (Homo sapiens)9068941associated with hepatitis B and DNA:SNP: :rs4730775(human)RGDPMID:28328801 and REF_RGD_ID:14402040
Wnt2Naked Mole-Ratprostate cancer  ISOWNT2 (Homo sapiens)9068941mRNA:decreased expression:prostate glandRGDPMID:14517837 and REF_RGD_ID:727214
Wnt2Naked Mole-Raturinary system cancer  ISOWNT2 (Homo sapiens)9068941DNA:amplificationRGDPMID:8064891 and REF_RGD_ID:2291877
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt2Naked Mole-Ratcystic fibrosis  ISOWNT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Cystic fibrosisClinVarPMID:11781704 more ...
Wnt2Naked Mole-Ratpleomorphic xanthoastrocytoma  ISOWNT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Wnt2Naked Mole-Ratrenal cell carcinoma  ISOWNT2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:28492532
Wnt2Naked Mole-RatRenal Cell Carcinoma 1  ISOWNT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Renal cell carcinoma 1ClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt2Naked Mole-Ratautistic disorder  ISOWNT2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:11449391 and PMID:19895723
Wnt2Naked Mole-RatUterine Cervical Neoplasms  ISOWNT2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25061499


Biological Process
1 to 20 of 36 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt2Naked Mole-Ratanimal organ development involved_inIEAARBA:ARBA00029247150520179 UniProtGO_REF:0000117
Wnt2Naked Mole-Ratatrial cardiac muscle tissue morphogenesis acts_upstream_of_or_withinISOMGI:43611559068941 PMID:20159597MGIPMID:20159597
Wnt2Naked Mole-Ratcanonical Wnt signaling pathway involved_inIEAPANTHER:PTN000246790150520179 TreeGrafterGO_REF:0000118
Wnt2Naked Mole-Ratcanonical Wnt signaling pathway acts_upstream_of_or_withinISOWnt2 (Mus musculus)9068941 PMID:9652750MGIPMID:9652750
Wnt2Naked Mole-Ratcanonical Wnt signaling pathway acts_upstream_of_or_withinISOMGI:43611559068941 PMID:20159597MGIPMID:20159597
Wnt2Naked Mole-Ratcanonical Wnt signaling pathway acts_upstream_of_or_withinISOMGI:12618349068941 PMID:19686689MGIPMID:19686689
Wnt2Naked Mole-Ratcardiac epithelial to mesenchymal transition acts_upstream_of_or_withinISOMGI:43611559068941 PMID:20159597MGIPMID:20159597
Wnt2Naked Mole-Ratcardiac muscle cell proliferation acts_upstream_ofISOMGI:43611559068941 PMID:20159597MGIPMID:20159597
Wnt2Naked Mole-Ratcell fate commitment involved_inIEAPANTHER:PTN000246790150520179 TreeGrafterGO_REF:0000118
Wnt2Naked Mole-Ratcell proliferation in midbrain involved_inISOWNT2 (Homo sapiens)9068941 PMID:20018874ParkinsonsUK-UCLPMID:20018874
Wnt2Naked Mole-Ratcell proliferation in midbrain involved_inISOWnt2 (Mus musculus)9068941 PMID:20018874CACAOPMID:20018874
Wnt2Naked Mole-Ratcell-cell signaling involved_inISOWNT2 (Homo sapiens)9068941 PMID:10557084BHF-UCLPMID:10557084
Wnt2Naked Mole-Ratcellular response to transforming growth factor beta stimulus involved_inISOWNT2 (Homo sapiens)9068941 PMID:15040835UniProtPMID:15040835
Wnt2Naked Mole-Ratepithelial cell proliferation acts_upstream_ofISOMGI:43611559068941 PMID:19686689MGIPMID:19686689
Wnt2Naked Mole-Ratepithelial cell proliferation involved in lung morphogenesis acts_upstream_ofISOMGI:43611559068941 PMID:19686689MGIPMID:19686689
Wnt2Naked Mole-Ratlabyrinthine layer blood vessel development acts_upstream_of_or_withinISOMGI:21779359068941 PMID:8951051MGIPMID:8951051
Wnt2Naked Mole-Ratlung development  ISOWnt2 (Rattus norvegicus)9068941 RGDPMID:1377452 and REF_RGD_ID:2314905
Wnt2Naked Mole-Ratlung induction acts_upstream_of_or_withinISOMGI:12618349068941 PMID:19686689MGIPMID:19686689
Wnt2Naked Mole-Ratmammary gland epithelium development involved_inISOWNT2 (Homo sapiens)9068941 PMID:8168088UniProtPMID:8168088
Wnt2Naked Mole-Ratmesenchymal cell proliferation acts_upstream_ofISOMGI:43611559068941 PMID:19686689MGIPMID:19686689
1 to 20 of 36 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt2Naked Mole-Ratcollagen-containing extracellular matrix located_inISOWNT2 (Homo sapiens)9068941 PMID:15507471UniProtPMID:15507471
Wnt2Naked Mole-Ratcytoplasm located_inISOWNT2 (Homo sapiens)9068941 PMID:19038973 more ...UniProtPMID:19038973 more ...
Wnt2Naked Mole-Ratextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
Wnt2Naked Mole-Ratextracellular region located_inIEAInterPro:IPR005817 and InterPro:IPR009140150520179 InterProGO_REF:0000002
Wnt2Naked Mole-Ratextracellular space located_inIEAPANTHER:PTN000246790150520179 TreeGrafterGO_REF:0000118

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt2Naked Mole-Ratcytokine activity enablesIEAPANTHER:PTN000246790150520179 TreeGrafterGO_REF:0000118
Wnt2Naked Mole-Ratfrizzled binding enablesIEAPANTHER:PTN000246790150520179 TreeGrafterGO_REF:0000118
Wnt2Naked Mole-Ratprotein binding enablesISOUniProtKB:P110219068941 PMID:28514442 and PMID:33961781IntActPMID:28514442 and PMID:33961781
Wnt2Naked Mole-Ratprotein binding enablesISOUniProtKB:Q8N4749068941 PMID:10347172BHF-UCLPMID:10347172
Wnt2Naked Mole-Ratreceptor ligand activity enablesISOWNT2 (Homo sapiens)9068941 PMID:17948129BHF-UCLPMID:17948129
Wnt2Naked Mole-Ratreceptor ligand activity enablesISOWNT2 (Homo sapiens)9068941 PMID:10557084ParkinsonsUK-UCLPMID:10557084
Wnt2Naked Mole-Ratsignaling receptor binding enablesIEAInterPro:IPR005817 and InterPro:IPR009140150520179 InterProGO_REF:0000002

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt2Naked Mole-RatWnt signaling pathway  ISOWNT2 (Homo sapiens)9068941 RGD 
Wnt2Naked Mole-RatWnt signaling pathway  ISOWnt2 (Mus musculus)9068941 RGD 
Wnt2Naked Mole-RatWnt signaling, canonical pathway   ISOWNT2 (Homo sapiens)9068941 RGDPMID:18765832 and REF_RGD_ID:2313743
PMID:21993625   PMID:22301074   PMID:30032202  



Wnt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248272,045,595 - 2,089,442 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248272,045,733 - 2,088,284 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
WNT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387117,275,451 - 117,323,058 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7117,275,451 - 117,323,152 (-)EnsemblGRCh38hg38GRCh38
GRCh377116,915,505 - 116,963,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367116,704,518 - 116,750,579 (-)NCBINCBI36Build 36hg18NCBI36
Build 347116,511,232 - 116,557,294NCBI
Celera7111,724,862 - 111,771,525 (-)NCBICelera
Cytogenetic Map7q31.2NCBI
HuRef7111,282,485 - 111,328,966 (-)NCBIHuRef
CHM1_17116,850,055 - 116,896,705 (-)NCBICHM1_1
T2T-CHM13v2.07118,590,786 - 118,638,396 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27116,312,120 - 116,358,781 (-)NCBI
Wnt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,988,939 - 18,032,771 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl617,988,939 - 18,030,584 (-)EnsemblGRCm39 Ensembl
GRCm38617,985,474 - 18,032,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,988,940 - 18,030,585 (-)EnsemblGRCm38mm10GRCm38
MGSCv37617,938,940 - 17,980,445 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36617,938,940 - 17,980,356 (-)NCBIMGSCv36mm8
Celera618,070,129 - 18,111,436 (-)NCBICelera
Cytogenetic Map6A2NCBI
cM Map68.08NCBI
Wnt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8447,294,300 - 47,340,284 (-)NCBIGRCr8
mRatBN7.2446,328,408 - 46,374,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl446,333,998 - 46,374,402 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0445,286,845 - 45,332,899 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl445,292,437 - 45,332,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,892,395 - 45,936,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,649,783 - 43,689,596 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,857,074 - 43,859,488 (-)NCBI
Celera441,596,263 - 41,642,309 (-)NCBICelera
Cytogenetic Map4q22NCBI
Wnt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,984,170 - 23,027,705 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,988,208 - 23,024,530 (-)NCBIChiLan1.0ChiLan1.0
WNT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26154,101,025 - 154,151,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan176,111,284 - 6,161,665 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07109,244,772 - 109,291,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17121,939,254 - 121,985,862 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,936,031 - 121,985,862 (-)Ensemblpanpan1.1panPan2
WNT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11456,123,735 - 56,172,113 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1456,129,248 - 56,172,069 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1455,519,061 - 55,567,484 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01456,163,101 - 56,211,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1456,166,256 - 56,213,190 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11456,195,055 - 56,243,473 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01455,884,128 - 55,931,047 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01456,253,933 - 56,302,214 (-)NCBIUU_Cfam_GSD_1.0
Wnt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,819,573 - 44,865,128 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365891,825,209 - 1,866,889 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365891,825,209 - 1,866,898 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1828,946,326 - 28,993,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11828,945,825 - 28,993,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21830,790,071 - 30,838,269 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,955,517 - 86,005,664 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2185,955,145 - 86,001,730 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604217,730,443 - 17,777,632 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000003119   ⟹   ENSHGLP00000003064
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248272,045,595 - 2,089,442 (+)Ensembl
RefSeq Acc Id: XM_004865257   ⟹   XP_004865314
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248272,045,733 - 2,088,284 (+)NCBI
RefSeq Acc Id: XM_021244770   ⟹   XP_021100429
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248272,045,733 - 2,088,284 (+)NCBI
Protein RefSeqs XP_004865314 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100429 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB03922 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000003064
RefSeq Acc Id: XP_004865314   ⟸   XM_004865257
- Peptide Label: isoform X1
- UniProtKB: G5B3R0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100429   ⟸   XM_021244770
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RUZ2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000003064   ⟸   ENSHGLT00000003119



1 to 18 of 18 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000002291 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000003119 ENTREZGENE
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt2 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
KEGG Report hgl:101723565 UniProtKB/TrEMBL
NCBI Gene Wnt2 ENTREZGENE
PANTHER PROTEIN WNT-2 UniProtKB/TrEMBL
  PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT2PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0AAX6RUZ2 ENTREZGENE, UniProtKB/TrEMBL
  G5B3R0 ENTREZGENE, UniProtKB/TrEMBL
1 to 18 of 18 rows