RGD Reference Report - Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. - Rat Genome Database

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Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.

Authors: Huguet, EL  McMahon, JA  McMahon, AP  Bicknell, R  Harris, AL 
Citation: Huguet EL, etal., Cancer Res. 1994 May 15;54(10):2615-21.
RGD ID: 2291878
Pubmed: PMID:8168088   (View Abstract at PubMed)

Wnt gene expression was investigated by ribonuclease protection analysis in human breast cancer, nontumorous breast tissue, and a variety of human breast cell lines. We report the expression of Wnt3, Wnt4, and Wnt7b in human breast cell lines and Wnt2, Wnt3, Wnt4, and Wnt7b in human breast tissues. Wnt3a and Wnt7a were absent in the cell lines and tissues tested. The level of expression of Wnt2 and Wnt4 was 10- to 20-fold higher in fibroadenomas than it was in normal or malignant breast tissue, and in 10% of tumors Wnt7b expression was 30-fold higher than in normal or benign breast tissues. In contrast to the mouse, in which Wnt1 and Wnt3 are involved in tumorigenesis, our results suggest that Wnt2, Wnt4, and Wnt7b may be associated with abnormal proliferation in human breast tissue.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WNT7BHumanbreast fibroadenoma  IEP mRNA:increased expression:tumor:increased in 10% of malignant neoplasms vs normal tissue and fibroadenomasRGD 
Wnt7bRatbreast fibroadenoma  ISOWNT7B (Homo sapiens) RGD 
Wnt7bMousebreast fibroadenoma  ISOWNT7B (Homo sapiens) RGD 
WNT2HumanFibroadenoma  IEP mRNA:increased expression:breastRGD 
WNT4HumanFibroadenoma  IEP breast fibroadenoma and mRNA:increased expression:tumor:increased vs normal and malignant breast tissue (p=0.001)RGD 
Wnt2RatFibroadenoma  ISOWNT2 (Homo sapiens)mRNA:increased expression:breastRGD 
Wnt2MouseFibroadenoma  ISOWNT2 (Homo sapiens)mRNA:increased expression:breastRGD 
Wnt4RatFibroadenoma  ISOWNT4 (Homo sapiens)breast fibroadenomaRGD 
Wnt4MouseFibroadenoma  ISOWNT4 (Homo sapiens)breast fibroadenomaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Wnt2  (Wnt family member 2)
Wnt4  (Wnt family member 4)
Wnt7b  (Wnt family member 7B)

Genes (Mus musculus)
Wnt2  (wingless-type MMTV integration site family, member 2)
Wnt4  (wingless-type MMTV integration site family, member 4)
Wnt7b  (wingless-type MMTV integration site family, member 7B)

Genes (Homo sapiens)
WNT2  (Wnt family member 2)
WNT4  (Wnt family member 4)
WNT7B  (Wnt family member 7B)


Additional Information