Gpc3 (glypican 3) - Rat Genome Database

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Pathways
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Gene: Gpc3 (glypican 3) Heterocephalus glaber
Analyze
Symbol: Gpc3
Name: glypican 3
RGD ID: 18917312
Description: ENCODES a protein that exhibits peptidyl-dipeptidase inhibitor activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior axis specification (ortholog); body morphogenesis (ortholog); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; ASSOCIATED WITH Arterial Occlusive Diseases (ortholog); atypical teratoid rhabdoid tumor (ortholog); autistic disorder (ortholog); FOUND IN cell surface (inferred); collagen-containing extracellular matrix (inferred); extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glypican-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479713,230,932 - 13,678,742 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479713,234,741 - 13,678,542 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IEA,ISO)
anterior/posterior axis specification  (IEA,ISO)
body morphogenesis  (IEA,ISO)
bone mineralization  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell migration  (IEA)
cell proliferation involved in kidney development  (IEA,ISO)
cell proliferation involved in metanephros development  (IEA,ISO)
coronary vasculature development  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
kidney development  (IEA,ISO)
lung development  (IEA,ISO)
mesenchymal cell proliferation involved in ureteric bud development  (IEA)
mesonephric duct morphogenesis  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of growth  (IEA,ISO)
negative regulation of smoothened signaling pathway  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
positive regulation of BMP signaling pathway  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of endocytosis  (IEA,ISO)
positive regulation of glucose import  (IEA,ISO)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of smoothened signaling pathway  (IEA,ISO)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of growth  (IEA,ISO)
regulation of non-canonical Wnt signaling pathway  (ISO)
regulation of protein localization to membrane  (IEA)
regulation of signal transduction  (IEA)
response to bacterium  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gpc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479713,230,932 - 13,678,742 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479713,234,741 - 13,678,542 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GPC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X133,535,745 - 133,985,594 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX133,535,745 - 133,987,100 (-)EnsemblGRCh38hg38GRCh38
GRCh37X132,669,773 - 133,119,621 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X132,497,439 - 132,947,332 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X132,395,297 - 132,845,186NCBI
CeleraX133,056,670 - 133,506,461 (-)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX122,070,349 - 122,518,471 (-)NCBIHuRef
CHM1_1X132,581,479 - 133,031,377 (-)NCBICHM1_1
T2T-CHM13v2.0X131,860,879 - 132,310,724 (-)NCBIT2T-CHM13v2.0
Gpc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X51,361,303 - 51,702,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX51,361,303 - 51,702,827 (-)EnsemblGRCm39 Ensembl
GRCm38X52,272,426 - 52,613,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,272,426 - 52,613,950 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X49,625,603 - 49,967,151 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X48,517,053 - 48,858,548 (-)NCBIMGSCv36mm8
CeleraX39,684,455 - 40,028,880 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX28.74NCBI
Gpc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X136,789,770 - 137,157,598 (-)NCBIGRCr8
mRatBN7.2X131,868,986 - 132,236,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX131,868,990 - 132,236,798 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,029,733 - 134,399,032 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X137,611,682 - 137,980,983 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X135,180,258 - 135,549,530 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X139,579,268 - 139,947,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX139,579,268 - 139,916,883 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X139,625,383 - 139,993,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X139,192,115 - 139,560,649 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X139,264,617 - 139,634,082 (-)NCBI
CeleraX130,783,069 - 131,149,772 (-)NCBICelera
Cytogenetic MapXq36NCBI
Gpc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955473969,800 - 1,431,483 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955473969,627 - 1,431,706 (+)NCBIChiLan1.0ChiLan1.0
GPC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X132,962,618 - 133,417,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X132,966,213 - 133,421,264 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X122,677,072 - 123,131,511 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X132,979,890 - 133,432,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX132,979,612 - 133,432,441 (-)Ensemblpanpan1.1panPan2
GPC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X104,313,426 - 104,751,215 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX104,313,591 - 104,751,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX90,423,525 - 90,861,387 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X106,172,656 - 106,610,807 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX106,172,666 - 106,610,973 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X103,586,071 - 104,023,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X105,451,609 - 105,889,924 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X105,234,374 - 105,675,118 (-)NCBIUU_Cfam_GSD_1.0
Gpc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X102,497,623 - 102,897,321 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366911,059,994 - 1,459,740 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366911,060,013 - 1,459,736 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX109,536,504 - 109,973,607 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X109,536,495 - 109,973,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X125,676,131 - 126,059,402 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X108,688,706 - 109,143,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606546,279,325 - 46,740,727 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000007109   ⟹   ENSHGLP00000007025
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462479713,230,932 - 13,678,742 (-)Ensembl
RefSeq Acc Id: XM_004860081   ⟹   XP_004860138
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479713,234,741 - 13,678,542 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004860138 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007025
  ENSHGLP00100036764
GenBank Protein JAN96196 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004860138   ⟸   XM_004860081
- UniProtKB: A0A0P6J7F2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000007025   ⟸   ENSHGLT00000007109


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005130 Ensembl, ENTREZGENE
  ENSHGLG00100000126 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000007109 ENTREZGENE
  ENSHGLT00100069163 UniProtKB/TrEMBL
InterPro Glypican UniProtKB/TrEMBL
  Glypican_CS UniProtKB/TrEMBL
KEGG Report hgl:101711973 UniProtKB/TrEMBL
NCBI Gene Gpc3 ENTREZGENE
PANTHER PTHR10822 UniProtKB/TrEMBL
  PTHR10822:SF4 UniProtKB/TrEMBL
Pfam Glypican UniProtKB/TrEMBL
PROSITE GLYPICAN UniProtKB/TrEMBL
UniProt A0A0P6J7F2 ENTREZGENE, UniProtKB/TrEMBL