RGD Reference Report - Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification. - Rat Genome Database

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Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification.

Authors: Xu, Xiaoliang  Yin, Yin  Tang, Junwei  Xie, Yu  Han, Zhuo  Zhang, Xudong  Liu, Qiaoyu  Qin, Xihu  Huang, Xinli  Sun, Beicheng 
Citation: Xu X, etal., Cell Death Dis. 2017 Oct 12;8(10):e3124. doi: 10.1038/cddis.2017.519.
RGD ID: 150520022
Pubmed: PMID:29022910   (View Abstract at PubMed)
PMCID: PMC5682683   (View Article at PubMed Central)
DOI: DOI:10.1038/cddis.2017.519   (Journal Full-text)

Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we confirmed a new long non-coding RNA Myd88 aberrant upregulated in HCC located upstream of Myd88 and verified a positive regulation relationship between them indicating that Lnc-Myd88 might participate in the enhanced expression of Myd88 in HCC. The gain- and loss-of-function analysis revealed that Lnc-Myd88 could promote the proliferation and metastasis of HCC both in vitro and in vivo. In addition, ChIP assays demonstrated that Lnc-Myd88 might increase Myd88 expression through enhancing H3K27Ac in the promoter of Myd88 gene, thus resulting in the activation of both NF-κB and PI3K/AKT signal pathways. In conclusion, we proposed that Lnc-Myd88 might serve as a novel diagnosis and therapeutic target for HCC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MYD88Humanhepatocellular carcinoma  IEP mRNA:increased expression:liver (human)RGD 
Myd88Rathepatocellular carcinoma  ISOMYD88 (Homo sapiens)mRNA:increased expression:liver (human)RGD 
Myd88Mousehepatocellular carcinoma  ISOMYD88 (Homo sapiens)mRNA:increased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Myd88  (MYD88, innate immune signal transduction adaptor)

Genes (Mus musculus)
Myd88  (myeloid differentiation primary response gene 88)

Genes (Homo sapiens)
MYD88  (MYD88 innate immune signal transduction adaptor)


Additional Information