Srebf1 (sterol regulatory element binding transcription factor 1) - Rat Genome Database

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Gene: Srebf1 (sterol regulatory element binding transcription factor 1) Heterocephalus glaber
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Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
RGD ID: 18932912
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cellular response to insulin stimulus (ortholog); cellular response to starvation (ortholog); PARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); atherosclerosis (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sterol regulatory element-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,602,261 - 3,623,465 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,602,103 - 3,623,922 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to fatty acid  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to starvation  (ISO)
cholesterol biosynthetic process  (ISO)
cholesterol metabolic process  (IEA,ISO)
circadian rhythm  (ISO)
fat cell differentiation  (ISO)
insulin receptor signaling pathway  (ISO)
insulin secretion  (ISO)
lipid biosynthetic process  (ISO)
lung development  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of triglyceride metabolic process  (ISO)
positive regulation of cholesterol biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of fatty acid metabolic process  (ISO)
regulation of heart rate by chemical signal  (ISO)
regulation of insulin secretion  (ISO)
regulation of mitophagy  (ISO)
regulation of protein stability  (ISO)
regulation of protein targeting to mitochondrion  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to cAMP  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to food  (ISO)
response to fructose  (ISO)
response to glucagon  (ISO)
response to glucose  (ISO)
response to lipid  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to progesterone  (ISO)
response to retinoic acid  (ISO)
response to xenobiotic stimulus  (ISO)
SREBP signaling pathway  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Srebf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,602,261 - 3,623,465 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,602,103 - 3,623,922 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SREBF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381717,811,334 - 17,836,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1717,810,399 - 17,837,002 (-)EnsemblGRCh38hg38GRCh38
GRCh371717,714,648 - 17,740,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,656,111 - 17,681,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 341717,656,110 - 17,681,050NCBI
Celera1718,654,135 - 18,680,982 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,466,908 - 17,494,061 (-)NCBIHuRef
CHM1_11717,723,458 - 17,749,109 (-)NCBICHM1_1
T2T-CHM13v2.01717,757,927 - 17,783,669 (-)NCBIT2T-CHM13v2.0
Srebf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,089,910 - 60,113,407 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,089,915 - 60,113,407 (-)EnsemblGRCm39 Ensembl
GRCm381160,199,084 - 60,224,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,199,089 - 60,222,581 (-)EnsemblGRCm38mm10GRCm38
MGSCv371160,012,591 - 60,034,106 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,015,284 - 60,036,799 (-)NCBIMGSCv36mm8
Celera1166,655,030 - 66,676,425 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.81NCBI
Srebf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,507,152 - 45,529,164 (-)NCBIGRCr8
mRatBN7.21045,007,637 - 45,029,650 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,007,637 - 45,029,650 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,707,833 - 49,729,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,198,201 - 49,220,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,701,803 - 44,723,821 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,570,996 - 46,593,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,570,996 - 46,593,009 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,326,015 - 46,348,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,461,684 - 46,483,646 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,264,866 - 44,286,830 (-)NCBICelera
Cytogenetic Map10q22NCBI
Srebf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577171,425 - 186,046 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577171,425 - 183,669 (+)NCBIChiLan1.0ChiLan1.0
SREBF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21952,328,005 - 52,355,769 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11757,040,217 - 57,065,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01733,458,196 - 33,484,643 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,405,794 - 38,432,045 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,405,794 - 38,432,045 (+)Ensemblpanpan1.1panPan2
SREBF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,663,809 - 41,686,764 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,663,773 - 41,686,776 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,802,335 - 41,825,236 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,769,693 - 41,792,654 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,769,687 - 41,925,702 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1541,737,352 - 41,760,245 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,684,736 - 41,707,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,876,687 - 41,899,587 (+)NCBIUU_Cfam_GSD_1.0
Srebf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,447,521 - 61,458,579 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,406,521 - 1,419,776 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,408,669 - 1,419,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SREBF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,733,907 - 60,751,267 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,733,967 - 60,750,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SREBF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,847,603 - 16,874,239 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1616,845,491 - 16,859,554 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660594,037,449 - 4,063,735 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000027113   ⟹   ENSHGLP00000026874
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248493,602,261 - 3,623,465 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000027114   ⟹   ENSHGLP00000026875
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248493,602,261 - 3,623,465 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000027115   ⟹   ENSHGLP00000026876
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248493,602,261 - 3,623,465 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000027116   ⟹   ENSHGLP00000026877
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248493,613,001 - 3,623,465 (+)Ensembl
RefSeq Acc Id: XM_004868711   ⟹   XP_004868768
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248493,602,261 - 3,623,922 (+)NCBI
RefSeq Acc Id: XM_004868713   ⟹   XP_004868770
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248493,602,103 - 3,623,465 (+)NCBI
RefSeq Acc Id: XM_021247481   ⟹   XP_021103140
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248493,612,881 - 3,623,465 (+)NCBI
RefSeq Acc Id: XM_021247482   ⟹   XP_021103141
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248493,613,057 - 3,623,465 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004868768 (Get FASTA)   NCBI Sequence Viewer  
  XP_004868770 (Get FASTA)   NCBI Sequence Viewer  
  XP_021103140 (Get FASTA)   NCBI Sequence Viewer  
  XP_021103141 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026874
  ENSHGLP00000026877
RefSeq Acc Id: XP_004868770   ⟸   XM_004868713
- Peptide Label: isoform X4
- UniProtKB: G5BMW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004868768   ⟸   XM_004868711
- Peptide Label: isoform X1
- UniProtKB: G5BMW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021103140   ⟸   XM_021247481
- Peptide Label: isoform X2
- UniProtKB: G5BMW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021103141   ⟸   XM_021247482
- Peptide Label: isoform X3
- UniProtKB: G5BMW6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000026874   ⟸   ENSHGLT00000027113
Ensembl Acc Id: ENSHGLP00000026877   ⟸   ENSHGLT00000027116
Ensembl Acc Id: ENSHGLP00000026875   ⟸   ENSHGLT00000027114
Ensembl Acc Id: ENSHGLP00000026876   ⟸   ENSHGLT00000027115


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019114 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000027113 ENTREZGENE
  ENSHGLT00000027116 ENTREZGENE
Gene3D-CATH Helix-loop-helix DNA-binding domain UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene Srebf1 ENTREZGENE
PANTHER STEROL REGULATORY ELEMENT-BINDING PROTEIN UniProtKB/TrEMBL
  STEROL REGULATORY ELEMENT-BINDING PROTEIN 1 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP HLH, helix-loop-helix DNA-binding domain UniProtKB/TrEMBL
UniProt G5BMW6 ENTREZGENE, UniProtKB/TrEMBL