Gene: Scap (SREBF chaperone) Rattus norvegicus
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Symbol:
Scap
Name:
SREBF chaperone
RGD ID:
1309378
Description:
Predicted to have sterol binding activity. Involved in aging. Localizes to intracellular membrane-bounded organelle and protein-containing complex. Orthologous to human SCAP (SREBF chaperone); PARTICIPATES IN sterol regulatory element-binding protein signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; amphetamine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC301024; SREBP cleavage activating protein; SREBP cleavage-activating protein; sterol regulatory element-binding protein cleavage-activating protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SCAP (SREBF chaperone) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Scap (SREBF chaperone) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Scap (SREBF chaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SCAP (SREBF chaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SCAP (SREBF chaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Scap (SREBF chaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SCAP (SREBF chaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
SCAP (SREBF chaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Scap (SREBF chaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Scap (SREBF chaperone)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Homo sapiens (human):
SCAP (SREBF chaperone)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
scap (SREBF chaperone)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
scp-1
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
SCAP
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 8 118,551,869 - 118,628,650 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 118,570,503 - 118,628,651 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 8 117,895,671 - 117,972,292 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 114,706,479 - 114,761,342 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 8 114,725,918 - 114,780,799 (+) NCBI Celera 8 109,591,567 - 109,646,089 (+) NCBI Celera Cytogenetic Map 8 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
hepatocellular carcinoma ISO RGD:1604827 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14563831
Gene-Chemical Interaction Annotations
1,2-dimethylhydrazine multiple interactions ISO RGD:1319695 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SCAP mRNA CTD PMID:22206623 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1604827 6480464 Dihydrotestosterone results in increased expression of SCAP mRNA CTD PMID:29581250 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1319695 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1604827 6480464 Tetrachlorodibenzodioxin results in decreased expression of SCAP mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SCAP mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1319695 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1319695 6480464 Tetrachlorodibenzodioxin results in decreased expression of SCAP mRNA CTD PMID:23238561 , PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SCAP mRNA CTD PMID:23238561 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1319695 6480464 Tetrachlorodibenzodioxin affects the expression of SCAP mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1319695 6480464 Tetrachlorodibenzodioxin results in increased expression of SCAP mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1604827 6480464 Tetrachlorodibenzodioxin results in increased expression of SCAP mRNA CTD PMID:19684285 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of SCAP mRNA CTD PMID:21346803 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of SCAP mRNA CTD PMID:30779732 arsane affects methylation ISO RGD:1604827 6480464 Arsenic affects the methylation of SCAP gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1604827 6480464 Arsenic affects the methylation of SCAP gene CTD PMID:25304211 benzo[a]pyrene increases methylation ISO RGD:1604827 6480464 Benzo(a)pyrene results in increased methylation of SCAP promoter CTD PMID:27901495 benzo[a]pyrene decreases methylation ISO RGD:1604827 6480464 Benzo(a)pyrene results in decreased methylation of SCAP 5' UTR CTD PMID:27901495 bezafibrate decreases expression ISO RGD:1319695 6480464 Bezafibrate results in decreased expression of SCAP mRNA, Bezafibrate results in decreased expression of SCAP protein CTD PMID:19124612 bezafibrate multiple interactions ISO RGD:1319695 6480464 PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP mRNA], PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP protein] CTD PMID:19124612 bezafibrate increases expression ISO RGD:1319695 6480464 Bezafibrate results in increased expression of SCAP mRNA, Bezafibrate results in increased expression of SCAP protein CTD PMID:19124612 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1319695 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of SCAP mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1604827 6480464 bisphenol A results in increased expression of SCAP mRNA CTD PMID:29275510 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SCAP gene CTD PMID:28505145 bisphenol A multiple interactions ISO RGD:1319695 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 carbon nanotube decreases expression ISO RGD:1319695 6480464 Nanotubes, Carbon analog results in decreased expression of SCAP mRNA, Nanotubes, Carbon results in decreased expression of SCAP mRNA CTD PMID:25620056 copper(II) sulfate decreases expression ISO RGD:1604827 6480464 Copper Sulfate results in decreased expression of SCAP mRNA CTD PMID:19549813 crocidolite asbestos affects expression ISO RGD:1604827 6480464 Asbestos, Crocidolite affects the expression of SCAP mRNA CTD PMID:17331233 cyproconazole decreases expression ISO RGD:1319695 6480464 cyproconazole results in decreased expression of SCAP mRNA CTD PMID:22334560 doxorubicin decreases expression ISO RGD:1604827 6480464 Doxorubicin results in decreased expression of SCAP mRNA CTD PMID:29803840 epoxiconazole decreases expression ISO RGD:1319695 6480464 epoxiconazole results in decreased expression of SCAP mRNA CTD PMID:22334560 ethanol increases expression ISO RGD:1319695 6480464 Ethanol results in increased expression of SCAP mRNA CTD PMID:30319688 ethanol affects splicing ISO RGD:1319695 6480464 Ethanol affects the splicing of SCAP mRNA CTD PMID:30319688 finasteride increases expression EXP 6480464 Finasteride results in increased expression of SCAP mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1319695 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SCAP mRNA CTD PMID:22206623 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of SCAP mRNA CTD PMID:22061828 hydralazine multiple interactions ISO RGD:1604827 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of SCAP mRNA CTD PMID:17183730 lovastatin multiple interactions ISO RGD:1319695 6480464 [Dietary Fats co-treated with Lovastatin] affects the expression of SCAP mRNA CTD PMID:29852127 menadione affects expression ISO RGD:1604827 6480464 Vitamin K 3 affects the expression of SCAP mRNA CTD PMID:20044591 perfluorooctanoic acid decreases expression ISO RGD:1319695 6480464 perfluorooctanoic acid results in decreased expression of SCAP protein CTD PMID:25092180 pirinixic acid increases expression ISO RGD:1319695 6480464 pirinixic acid results in increased expression of SCAP mRNA CTD PMID:17426115 propiconazole decreases expression ISO RGD:1319695 6480464 propiconazole results in decreased expression of SCAP mRNA CTD PMID:22334560 rotenone increases expression EXP 6480464 Rotenone results in increased expression of SCAP mRNA CTD PMID:28374803 simvastatin affects response to substance ISO RGD:1604827 6480464 SCAP polymorphism affects the susceptibility to Simvastatin CTD PMID:16158080 sodium arsenite affects methylation ISO RGD:1604827 6480464 sodium arsenite affects the methylation of SCAP gene CTD PMID:28589171 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of SCAP mRNA CTD PMID:31150632 tetrachloromethane decreases expression ISO RGD:1319695 6480464 Carbon Tetrachloride results in decreased expression of SCAP mRNA CTD PMID:31919559 thapsigargin decreases expression ISO RGD:1319695 6480464 Thapsigargin results in decreased expression of SCAP protein CTD PMID:24648495 tungsten decreases expression ISO RGD:1319695 6480464 Tungsten results in decreased expression of SCAP mRNA CTD PMID:30912803 valproic acid multiple interactions ISO RGD:1604827 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of SCAP mRNA CTD PMID:17183730 valproic acid increases expression ISO RGD:1604827 6480464 Valproic Acid results in increased expression of SCAP mRNA CTD PMID:23179753 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of SCAP mRNA CTD PMID:22570695 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of SCAP mRNA CTD PMID:23034163
Gene Ontology Annotations
Biological Process aging IEP 1581819 RGD cellular lipid metabolic process ISO RGD:1319695 1624291 MGI:MGI:2148743 (MGI:MGI:5311965 , PMID:22337502) RGD MGI:MGI:5311965 , PMID:22337502 cholesterol metabolic process ISO RGD:1319695 1624291 (MGI:MGI:1934968, PMID:11358865) RGD MGI:MGI:1934968 , PMID:11358865 cholesterol metabolic process ISS UniProtKB:P97260 1600115 GO_REF:0000024 UniProt GO_REF:0000024 COPII-coated vesicle cargo loading ISS UniProtKB:P97260 1600115 GO_REF:0000024 UniProt GO_REF:0000024 immune response ISO RGD:1319695 1624291 MGI:MGI:2148743 (MGI:MGI:5311965 , PMID:22337502) RGD MGI:MGI:5311965 , PMID:22337502 positive regulation of cholesterol biosynthetic process ISO RGD:1604827 1624291 (PMID:32322062) RGD PMID:32322062 regulation of cholesterol biosynthetic process ISO RGD:1319695 1624291 MGI:MGI:2148743 more ... RGD MGI:MGI:3770209 , PMID:16054043 regulation of fatty acid biosynthetic process ISO RGD:1319695 1624291 MGI:MGI:2148743 more ... RGD MGI:MGI:3770209 , PMID:16054043 regulation of fatty acid metabolic process ISO RGD:1319695 1624291 (MGI:MGI:1934968, PMID:11358865) RGD MGI:MGI:1934968 , PMID:11358865 response to hypoxia ISO RGD:1319695 1624291 MGI:MGI:2148743 more ... RGD MGI:MGI:3767718 , PMID:17666524 response to insulin ISO RGD:1319695 1624291 MGI:MGI:2148743 more ... RGD MGI:MGI:3770209 , PMID:16054043 SREBP signaling pathway ISO RGD:1604827 1624291 (PMID:11726962), (PMID:32322062) RGD PMID:11726962 , PMID:32322062 SREBP signaling pathway ISS UniProtKB:P97260 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Cellular Component endoplasmic reticulum membrane ISO RGD:1319695 1624291 (MGI:MGI:2388133, PMID:12242332) RGD MGI:MGI:2388133 , PMID:12242332 endoplasmic reticulum membrane ISS UniProtKB:Q12770 1600115 GO_REF:0000024 UniProt GO_REF:0000024 endoplasmic reticulum membrane ISO RGD:1604827 1624291 (PMID:32111832) RGD PMID:32111832 ER to Golgi transport vesicle membrane IEA UniProtKB-SubCell:SL-0078 1600115 GO_REF:0000044 UniProt GO_REF:0000044 Golgi membrane ISO RGD:1604827 1624291 (PMID:32111832) RGD PMID:32111832 Golgi membrane ISS UniProtKB:Q12770 1600115 GO_REF:0000024 UniProt GO_REF:0000024 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 intracellular membrane-bounded organelle IDA 2308803 RGD protein-containing complex IDA 2308803 RGD Molecular Function protein binding ISO RGD:1319695 1624291 PR:Q8BGI3 more ... RGD MGI:MGI:2388133 , PMID:12242332 protein binding ISO RGD:1604827 1624291 UniProtKB:Q8WU17 more ... RGD PMID:17428920 more ... protein-containing complex binding IPI RGD:728328 , RGD:1350460 2308803 RGD sterol binding ISS UniProtKB:P97260 1600115 GO_REF:0000024 UniProt GO_REF:0000024
Molecular Pathway Annotations
1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 8 9531047 119211942 Rat 631650 Stl6 Serum triglyceride level QTL 6 4 0.0019 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 8 10938911 120496129 Rat 70197 BpQTLcluster8 Blood pressure QTL cluster 8 3.482 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 50529480 128036471 Rat 70197 BpQTLcluster8 Blood pressure QTL cluster 8 3.482 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) 8 50529480 128036471 Rat 70197 BpQTLcluster8 Blood pressure QTL cluster 8 3.482 arterial blood pressure trait (VT:2000000) absolute change in systolic blood pressure (CMO:0000607) 8 50529480 128036471 Rat 70197 BpQTLcluster8 Blood pressure QTL cluster 8 3.482 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 8 50529480 128036471 Rat 2303171 Bp331 Blood pressure QTL 331 5.57 0.005 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 8 65717449 128033050 Rat 631210 Bw3 Body weight QTL3 5.9 mesenteric fat pad mass (VT:0010427) mesenteric fat pad weight as a percentage of body weight (CMO:0000654) 8 74917593 121080545 Rat 1300171 Bp184 Blood pressure QTL 184 3.66 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) 8 76103982 127182642 Rat 9590292 Uminl3 Urine mineral level QTL 3 3.62 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 8 78805083 123805083 Rat 8694446 Bw170 Body weight QTL 170 12.07 0.001 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) 8 78805083 123805083 Rat 8694200 Abfw4 Abdominal fat weight QTL 4 9.07 0.001 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) 8 78805083 123805083 Rat 8694392 Bw161 Body weight QTL 161 8.06 0.001 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) 8 78805083 123805083 Rat 1549909 Stresp11 Stress response QTL 11 6.83 0.0019 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 8 80697934 125697934 Rat 2300181 Bmd55 Bone mineral density QTL 55 5.7 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 8 83894304 128894304 Rat 61437 Cia6 Collagen induced arthritis QTL 6 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 8 89058229 132243842 Rat 2313400 Anxrr25 Anxiety related response QTL 25 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 8 95963141 122354314 Rat 1358893 Bp263 Blood pressure QTL 263 5.01 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 100873811 133307652 Rat 1358903 Bp252 Blood pressure QTL 252 7 0.0001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 100873811 133307652 Rat 738011 Anxrr9 Anxiety related response QTL 9 6.1 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 8 102051964 133307652 Rat 738014 Anxrr15 Anxiety related response QTL 15 3.6 0.005 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 8 104682575 133307652 Rat 2300182 Bmd56 Bone mineral density QTL 56 5.4 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 8 104682575 133307652 Rat 724539 Cm19 Cardiac mass QTL 19 2.6 heart mass (VT:0007028) calculated heart weight (CMO:0000073) 8 107769005 129956433 Rat
Predicted Target Of
Count of predictions: 135 Count of miRNA genes: 113 Interacting mature miRNAs: 118 Transcripts: ENSRNOT00000028295 Prediction methods: Microtar, Miranda, Rnahybrid Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
