Srebf1 (sterol regulatory element binding transcription factor 1) - Rat Genome Database

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Gene: Srebf1 (sterol regulatory element binding transcription factor 1) Chinchilla lanigera
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Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
RGD ID: 9062386
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN aging (ortholog); cellular response to fatty acid (ortholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); autistic disorder (ortholog); Diabetic Nephropathies (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: sterol regulatory element-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577171,425 - 186,046 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577171,425 - 183,669 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
cellular response to fatty acid  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to starvation  (ISO)
cholesterol metabolic process  (ISO)
circadian rhythm  (ISO)
fat cell differentiation  (ISO)
insulin receptor signaling pathway  (ISO)
lipid biosynthetic process  (ISO)
lipid localization  (ISO)
lung development  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of cholesterol biosynthetic process  (ISO)
positive regulation of histone deacetylation  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
regulation of autophagy of mitochondrion  (ISO)
regulation of fatty acid metabolic process  (ISO)
regulation of heart rate by chemical signal  (ISO)
regulation of insulin secretion  (ISO)
regulation of lipid storage  (ISO)
regulation of protein stability  (ISO)
regulation of protein targeting to mitochondrion  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to cAMP  (ISO)
response to drug  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to food  (ISO)
response to glucagon  (ISO)
response to glucose  (ISO)
response to lipid  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to progesterone  (ISO)
response to retinoic acid  (ISO)
SREBP signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Srebf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577171,425 - 186,046 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577171,425 - 183,669 (+)NCBIChiLan1.0ChiLan1.0
SREBF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1717,810,399 - 17,837,002 (-)EnsemblGRCh38hg38GRCh38
GRCh381717,811,334 - 17,837,017 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371717,714,648 - 17,740,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,656,111 - 17,681,050 (-)NCBINCBI36hg18NCBI36
Build 341717,656,110 - 17,681,050NCBI
Celera1718,654,135 - 18,680,982 (-)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1717,466,908 - 17,494,061 (-)NCBIHuRef
CHM1_11717,723,458 - 17,749,109 (-)NCBICHM1_1
Srebf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,089,910 - 60,113,407 (-)NCBIGRCm39mm39
GRCm39 Ensembl1160,089,915 - 60,113,407 (-)Ensembl
GRCm381160,199,084 - 60,224,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,199,089 - 60,222,581 (-)EnsemblGRCm38mm10GRCm38
MGSCv371160,012,591 - 60,034,106 (-)NCBIGRCm37mm9NCBIm37
MGSCv361160,015,284 - 60,036,799 (-)NCBImm8
Celera1166,655,030 - 66,676,425 (+)NCBICelera
Cytogenetic Map11B2NCBI
Srebf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21045,007,637 - 45,029,650 (-)NCBI
Rnor_6.0 Ensembl1046,570,996 - 46,593,009 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01046,570,996 - 46,593,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01046,326,015 - 46,348,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,461,684 - 46,483,646 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1044,264,866 - 44,286,830 (-)NCBICelera
Cytogenetic Map10q22NCBI
SREBF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11738,405,794 - 38,432,045 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,405,794 - 38,432,045 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01733,458,196 - 33,484,643 (+)NCBIMhudiblu_PPA_v0panPan3
SREBF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,663,809 - 41,686,764 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,663,773 - 41,686,776 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,802,335 - 41,825,236 (+)NCBI
ROS_Cfam_1.0541,769,693 - 41,792,654 (+)NCBI
UMICH_Zoey_3.1541,737,352 - 41,760,245 (+)NCBI
UNSW_CanFamBas_1.0541,684,736 - 41,707,631 (+)NCBI
UU_Cfam_GSD_1.0541,876,687 - 41,899,587 (+)NCBI
Srebf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,447,521 - 61,458,579 (+)NCBI
SpeTri2.0NW_0049367411,408,669 - 1,419,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SREBF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,733,907 - 60,751,265 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,733,967 - 60,750,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SREBF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,847,603 - 16,874,239 (-)NCBI
ChlSab1.1 Ensembl1616,845,491 - 16,859,554 (-)Ensembl
Vero_WHO_p1.0NW_0236660594,037,449 - 4,063,735 (+)NCBI
Srebf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248493,602,103 - 3,623,922 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000000657   ⟹   ENSCLAP00000000624
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955577171,425 - 186,046 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000000658   ⟹   ENSCLAP00000000625
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955577174,720 - 183,247 (+)Ensembl
RefSeq Acc Id: XM_013509620   ⟹   XP_013365074
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955577171,425 - 183,669 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013365074 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013365074   ⟸   XM_013509620
- Sequence:
RefSeq Acc Id: ENSCLAP00000000624   ⟸   ENSCLAT00000000657
RefSeq Acc Id: ENSCLAP00000000625   ⟸   ENSCLAT00000000658


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000000502 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000000625 ENTREZGENE
Ensembl Transcript ENSCLAT00000000658 ENTREZGENE
NCBI Gene Srebf1 ENTREZGENE