RGD Reference Report - In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin-2. - Rat Genome Database

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In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin-2.

Authors: Bui, L A  Butterfield, L H  Kim, J Y  Ribas, A  Seu, P  Lau, R  Glaspy, J A  McBride, W H  Economou, J S 
Citation: Bui LA, etal., Hum Gene Ther. 1997 Dec 10;8(18):2173-82. doi: 10.1089/hum.1997.8.18-2173.
RGD ID: 14747035
Pubmed: PMID:9449371   (View Abstract at PubMed)
DOI: DOI:10.1089/hum.1997.8.18-2173   (Journal Full-text)

A recombinant adenovirus (AdVAFP1-IL2) containing the murine alpha-fetoprotein (AFP) promoter was constructed to direct hepatocellular carcinoma (HCC)-specific expression of the human interleukin-2 (IL-2) gene. In vitro testing of AdVAFP1-IL2 showed HCC-specific IL-2 gene expression three to four orders of magnitude higher in AFP-producing HCC lines compared to non-AFP producing non-HCC lines. The in vivo efficacy and tumor specificity of AdVAFP1-IL2 was evaluated compared to AdVCMV-IL2 (in which the IL-2 gene is driven by the strong constitutive cytomegalovirus promoter) in the treatment of established human HCC (Hep 3B/Hep G2) xenografts growing in CB-17/SCID mice. Intratumoral injection of AdV resulted in growth retardation and regression in a majority of established hepatomas, but with a much wider therapeutic index and less systemic toxicity using the AFP vector. This study illustrates the superiority of using transcriptionally targeted recombinant AdV vectors in cytokine-based gene therapy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL2Humanhepatocellular carcinoma treatmentIDA  RGD 
Il2Rathepatocellular carcinoma treatmentISOIL2 (Homo sapiens) RGD 
Il2Mousehepatocellular carcinoma treatmentISOIL2 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il2  (interleukin 2)

Genes (Mus musculus)
Il2  (interleukin 2)

Genes (Homo sapiens)
IL2  (interleukin 2)


Additional Information