Rad51 (RAD51 recombinase) - Rat Genome Database

Name: Rad51
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Rad51 (RAD51 recombinase) Heterocephalus glaber

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Symbol:

Rad51

Name:

RAD51 recombinase

RGD ID:

18922673

Description:

ENCODES a protein that exhibits chromatin binding (ortholog); DNA polymerase binding (ortholog); enzyme binding (ortholog); INVOLVED IN cellular response to alkaloid (ortholog); cellular response to camptothecin (ortholog); cellular response to cisplatin (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Bloom syndrome (ortholog); breast cancer (ortholog); Breast Cancer, Familial (ortholog); FOUND IN chromatin (ortholog); chromosome (ortholog); chromosome, telomeric region (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA repair protein RAD51 homolog 1; RAD51 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RAD51 (RAD51 recombinase)	NCBI	Ortholog
Mus musculus (house mouse):	Rad51 (RAD51 recombinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Rad51 (RAD51 recombinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rad51 (RAD51 recombinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RAD51 (RAD51 recombinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RAD51 (RAD51 recombinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rad51 (RAD51 recombinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RAD51 (RAD51 recombinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RAD51 (RAD51 recombinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	7,957,253 - 7,983,619 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	7,957,175 - 7,983,078 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

breast cancer (ISO)

Breast Cancer, Familial (ISO)

Breast Neoplasms (ISO)

cardiomyopathy (ISO)

colorectal cancer (ISO)

Experimental Liver Neoplasms (ISO)

Fanconi anemia complementation group R (ISO)

genetic disease (ISO)

Genetic Predisposition to Disease (ISO)

Head and Neck Neoplasms (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Hereditary Neoplastic Syndromes (ISO)

hypertension (ISO)

Hypoxia (ISO)

Micronuclei, Chromosome-Defective (ISO)

Mirror Movements 2 (ISO)

mosaic variegated aneuploidy syndrome 1 (ISO)

ovarian cancer (ISO)

ovary epithelial cancer (ISO)

pancreatic cancer (ISO)

Triple Negative Breast Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to alkaloid (ISO)

cellular response to camptothecin (ISO)

cellular response to cisplatin (ISO)

cellular response to gamma radiation (ISO)

cellular response to hydroxyurea (ISO)

cellular response to ionizing radiation (ISO)

chromosome organization involved in meiotic cell cycle (IEA,ISO)

DNA damage response (ISO)

DNA recombinase assembly (IEA)

DNA recombination (IEA)

DNA repair (IEA)

DNA strand invasion (IEA)

DNA unwinding involved in DNA replication (ISO)

double-strand break repair involved in meiotic recombination (ISO)

double-strand break repair via homologous recombination (IEA,ISO)

interstrand cross-link repair (ISO)

meiosis I (ISO)

meiotic cell cycle (ISO)

mitotic recombination (IEA)

mitotic recombination-dependent replication fork processing (IEA)

positive regulation of DNA ligation (ISO)

reciprocal meiotic recombination (IEA)

regulation of double-strand break repair via homologous recombination (ISO)

regulation of protein phosphorylation (ISO)

replication fork processing (ISO)

replication-born double-strand break repair via sister chromatid exchange (ISO)

response to glucoside (ISO)

response to organic cyclic compound (ISO)

response to toxic substance (ISO)

response to X-ray (ISO)

response to xenobiotic stimulus (ISO)

telomere maintenance via recombination (ISO)

telomere maintenance via telomere lengthening (ISO)

telomere organization (ISO)

Cellular Component

chromatin (ISO)

chromosome (ISO)

chromosome, telomeric region (ISO)

condensed chromosome (ISO)

condensed nuclear chromosome (IEA)

cytoplasm (ISO)

cytosol (ISO)

lateral element (ISO)

male germ cell nucleus (ISO)

mitochondrion (ISO)

nuclear chromosome (ISO)

nuclear ubiquitin ligase complex (ISO)

nucleolus (ISO)

nucleus (IEA,ISO)

perinuclear region of cytoplasm (ISO)

PML body (ISO)

presynaptic intermediate filament cytoskeleton (ISO)

protein-containing complex (ISO)

site of double-strand break (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATP-dependent activity, acting on DNA (IEA)

ATP-dependent DNA damage sensor activity (IEA)

chromatin binding (ISO)

DNA binding (IEA)

DNA polymerase binding (ISO)

DNA strand exchange activity (IEA)

double-stranded DNA binding (IEA)

enzyme binding (ISO)

identical protein binding (ISO)

protein binding (ISO)

single-stranded DNA binding (IEA)

single-stranded DNA helicase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

homologous recombination pathway of double-strand break repair (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Rad51
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	7,957,253 - 7,983,619 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	7,957,175 - 7,983,078 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

RAD51
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	40,694,733 - 40,732,340 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	40,694,774 - 40,732,340 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	40,987,372 - 41,024,538 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	38,774,651 - 38,811,648 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	38,774,660 - 38,811,646	NCBI
Celera	15	17,755,220 - 17,792,245 (+)	NCBI		Celera
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	17,834,870 - 17,872,189 (+)	NCBI		HuRef
CHM1_1	15	41,107,382 - 41,144,356 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	38,500,415 - 38,538,035 (+)	NCBI		T2T-CHM13v2.0

Rad51
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	118,943,295 - 118,966,554 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	118,943,274 - 118,977,926 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	119,112,814 - 119,136,073 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	119,112,793 - 119,147,445 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	118,938,553 - 118,961,806 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	118,804,258 - 118,827,511 (+)	NCBI		MGSCv36	mm8
Celera	2	120,265,474 - 120,286,601 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.92	NCBI

Rad51
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	126,554,210 - 126,578,888 (+)	NCBI		GRCr8
mRatBN7.2	3	106,099,753 - 106,125,038 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	106,100,381 - 106,125,035 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	109,773,488 - 109,798,183 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	118,369,034 - 118,393,719 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	116,029,412 - 116,054,104 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	110,918,240 - 110,942,920 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	110,918,243 - 110,942,917 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	117,468,402 - 117,493,566 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	105,625,265 - 105,650,392 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	105,013,953 - 105,038,371 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

Rad51
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	7,566,686 - 7,590,628 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	7,566,715 - 7,590,628 (+)	NCBI	ChiLan1.0	ChiLan1.0

RAD51
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	29,938,330 - 29,973,033 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	34,089,788 - 34,123,970 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	19,638,310 - 19,672,474 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	37,891,061 - 37,925,207 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	37,891,056 - 37,925,207 (+)	Ensembl	panpan1.1		panPan2

RAD51
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	7,842,540 - 7,877,128 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	7,842,540 - 7,877,606 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	7,896,289 - 7,931,113 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	7,968,785 - 8,004,039 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	7,968,784 - 8,004,029 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	7,892,599 - 7,927,542 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	7,999,640 - 8,034,564 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	8,128,251 - 8,163,404 (+)	NCBI		UU_Cfam_GSD_1.0

Rad51
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	86,263,812 - 86,288,764 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	4,114,530 - 4,136,248 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	4,119,020 - 4,136,811 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAD51
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	130,586,665 - 130,640,136 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	130,592,414 - 130,640,326 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	145,751,297 - 145,798,501 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAD51
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	42,281,085 - 42,319,394 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	42,279,608 - 42,318,169 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	98,661,431 - 98,701,069 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004861569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021241898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01072702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GEBF01001987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000025845 ⟹ ENSHGLP00000025618

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624804	7,957,253 - 7,983,619 (+)	Ensembl

RefSeq Acc Id:

XM_004861569 ⟹ XP_004861626

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624804	7,957,175 - 7,983,078 (+)	NCBI

RefSeq Acc Id:

XM_021241898 ⟹ XP_021097557

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624804	7,957,175 - 7,983,078 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_004861626	(Get FASTA)	NCBI Sequence Viewer
	XP_021097557	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000025618
	ENSHGLP00100035454
GenBank Protein	JAO01646	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_004861626 ⟸ XM_004861569
- Peptide Label:	isoform X1
- UniProtKB:	A0A0N8EUC2 (UniProtKB/TrEMBL), G5BLZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_021097557 ⟸ XM_021241898
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSHGLP00000025618 ⟸ ENSHGLT00000025845

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000018242	Ensembl, ENTREZGENE
	ENSHGLG00100007402	UniProtKB/TrEMBL
Ensembl Transcript	ENSHGLT00000025845	ENTREZGENE
	ENSHGLT00100079227	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
	5' to 3' exonuclease, C-terminal subdomain	UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/TrEMBL
	DNA_recomb/repair_Rad51	UniProtKB/TrEMBL
	DNA_recomb/repair_Rad51_C	UniProtKB/TrEMBL
	DNA_recomb/repair_RecA-like	UniProtKB/TrEMBL
	DNA_repair_Rad51/TF_NusA_a-hlx	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	RecA_ATP-bd	UniProtKB/TrEMBL
	RecA_monomer-monomer_interface	UniProtKB/TrEMBL
KEGG Report	hgl:101715048	UniProtKB/TrEMBL
NCBI Gene	Rad51	ENTREZGENE
PANTHER	DNA REPAIR PROTEIN RAD51 HOMOLOG 1	UniProtKB/TrEMBL
	RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER	UniProtKB/TrEMBL
Pfam	HHH_5	UniProtKB/TrEMBL
	Rad51	UniProtKB/TrEMBL
PIRSF	Rad51	UniProtKB/TrEMBL
PROSITE	RECA_2	UniProtKB/TrEMBL
	RECA_3	UniProtKB/TrEMBL
SMART	AAA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47794	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0N8EUC2	ENTREZGENE, UniProtKB/TrEMBL
	G5BLZ5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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