Igf2 (insulin like growth factor 2) - Rat Genome Database

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Pathways
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Gene: Igf2 (insulin like growth factor 2) Heterocephalus glaber
Analyze
Symbol: Igf2
Name: insulin like growth factor 2
RGD ID: 18910255
Description: ENCODES a protein that exhibits growth factor activity (inferred); hormone activity (inferred); insulin receptor binding (inferred); INVOLVED IN animal organ morphogenesis (ortholog); cellular response to mechanical stimulus (ortholog); exocrine pancreas development (ortholog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); adrenocortical carcinoma (ortholog); alcohol use disorder (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor II preproprotein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476714,969,866 - 14,979,026 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476714,969,977 - 14,997,577 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
adrenocortical carcinoma  (ISO)
alcohol use disorder  (ISO)
Alcoholic Liver Diseases  (ISO)
alcoholic neuropathy  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
Animal Mammary Neoplasms  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
bone development disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
choriocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (ISO)
delta beta-thalassemia  (ISO)
developmental and epileptic encephalopathy  (ISO)
Diabetic Nephropathies  (ISO)
Diaphragmatic Hernia  (ISO)
early infantile epileptic encephalopathy  (ISO)
Embryo Loss  (ISO)
Ependymomas  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Fetal Growth Retardation  (ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
Growth Disorders  (ISO)
Hepatic Echinococcosis  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hypoglycemia  (ISO)
immunodeficiency 39  (ISO)
inflammatory bowel disease  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
Lung Injury  (ISO)
Memory Disorders  (ISO)
meningitis  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Parkinson's disease  (ISO)
placenta disease  (ISO)
polyhydramnios  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-malignant neoplasm  (ISO)
rhabdomyosarcoma  (ISO)
rheumatoid arthritis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
Silver-Russell syndrome  (ISO)
Silver-Russell Syndrome 1  (ISO)
Silver-Russell Syndrome 3  (ISO)
Spontaneous Abortions  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ventricular septal defect  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IEA,ISO)
cellular response to mechanical stimulus  (ISO)
embryonic placenta development  (IEA)
embryonic placenta morphogenesis  (IEA)
exocrine pancreas development  (IEA,ISO)
female pregnancy  (ISO)
glucose metabolic process  (IEA)
in utero embryonic development  (IEA)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
memory  (ISO)
negative regulation of muscle cell differentiation  (IEA)
negative regulation of natural killer cell mediated cytotoxicity  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
ossification  (IEA)
osteoblast differentiation  (IEA)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of glycogen biosynthetic process  (IEA,ISO)
positive regulation of insulin receptor signaling pathway  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of organ growth  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of skeletal muscle tissue growth  (IEA)
positive regulation of steroid hormone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of vascular endothelial cell proliferation  (IEA)
regulation of muscle cell differentiation  (IEA)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
spongiotrophoblast cell proliferation  (IEA)
striated muscle cell differentiation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:26763976  


Genomics

Comparative Map Data
Igf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476714,969,866 - 14,979,026 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476714,969,977 - 14,997,577 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,129,117 - 2,149,566 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,129,112 - 2,158,391 (-)EnsemblGRCh38hg38GRCh38
GRCh37112,150,347 - 2,170,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,106,923 - 2,127,409 (-)NCBINCBI36Build 36hg18NCBI36
Build 34112,110,531 - 2,116,578NCBI
Celera112,186,838 - 2,207,338 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,940,869 - 1,961,095 (-)NCBIHuRef
CHM1_1112,148,973 - 2,169,786 (-)NCBICHM1_1
T2T-CHM13v2.0112,216,758 - 2,237,216 (-)NCBIT2T-CHM13v2.0
Igf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,204,505 - 142,220,566 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,204,503 - 142,220,553 (-)EnsemblGRCm39 Ensembl
GRCm387142,650,768 - 142,666,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,650,766 - 142,666,816 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,836,673 - 149,846,940 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,460,158 - 142,468,879 (-)NCBIMGSCv36mm8
Celera7142,407,105 - 142,417,364 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.99NCBI
Igf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,243,873 - 207,261,263 (-)NCBIGRCr8
mRatBN7.21197,814,409 - 197,831,802 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,814,410 - 197,823,018 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,187,237 - 206,197,377 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,273,145 - 213,283,290 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,947,308 - 205,957,453 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,828,102 - 215,839,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,828,102 - 215,846,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,722,921 - 222,733,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,906,624 - 202,915,231 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,094,689 - 203,103,297 (-)NCBI
Celera1195,432,460 - 195,442,561 (-)NCBICelera
Cytogenetic Map1q41NCBI
Igf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,880,471 - 13,888,566 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,880,525 - 13,907,963 (-)NCBIChiLan1.0ChiLan1.0
IGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,555,470 - 4,584,748 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,767,218 - 3,777,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,170,190 - 2,199,442 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,202,764 - 2,228,890 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,202,743 - 2,228,890 (-)Ensemblpanpan1.1panPan2
IGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,294,036 - 46,311,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,294,019 - 46,311,982 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,906,773 - 44,921,790 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,973,499 - 46,991,455 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1846,973,482 - 47,002,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,425,198 - 46,440,216 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,005,530 - 46,020,544 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,751,952 - 46,766,988 (-)NCBIUU_Cfam_GSD_1.0
Igf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,719,158 - 1,727,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816972,282 - 979,167 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936816972,902 - 981,232 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.121,469,183 - 1,496,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap2pNCBI
IGF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,937,414 - 1,951,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,936,830 - 1,945,388 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603899,135,565 - 99,144,253 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000025156   ⟹   ENSHGLP00000024934
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476714,969,866 - 14,979,026 (-)Ensembl
RefSeq Acc Id: XM_004852094   ⟹   XP_004852151
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476714,969,977 - 14,977,178 (-)NCBI
RefSeq Acc Id: XM_004852095   ⟹   XP_004852152
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476714,969,977 - 14,978,688 (-)NCBI
RefSeq Acc Id: XM_004852096   ⟹   XP_004852153
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476714,969,977 - 14,997,577 (-)NCBI
RefSeq Acc Id: XM_021264414   ⟹   XP_021120073
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476714,969,977 - 14,997,575 (-)NCBI
RefSeq Acc Id: XM_021264415   ⟹   XP_021120074
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476714,969,977 - 14,975,719 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004852153   ⟸   XM_004852096
- UniProtKB: A0A0A7HSI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120073   ⟸   XM_021264414
- UniProtKB: A0A0A7HSI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004852152   ⟸   XM_004852095
- UniProtKB: A0A0A7HSI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004852151   ⟸   XM_004852094
- UniProtKB: A0A0A7HSI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120074   ⟸   XM_021264415
- UniProtKB: A0A0A7HSI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000024934   ⟸   ENSHGLT00000025156


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017767 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100051653 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000025156 ENTREZGENE
  ENSHGLT00000045004 UniProtKB/TrEMBL
  ENSHGLT00100046494 UniProtKB/TrEMBL
Gene3D-CATH Insulin-like UniProtKB/TrEMBL
InterPro IGF2 UniProtKB/TrEMBL
  IGF2_C UniProtKB/TrEMBL
  Insulin-like UniProtKB/TrEMBL
  Insulin-like_growth_factor UniProtKB/TrEMBL
  Insulin-like_sf UniProtKB/TrEMBL
  Insulin_CS UniProtKB/TrEMBL
  Insulin_family UniProtKB/TrEMBL
KEGG Report hgl:101720309 UniProtKB/TrEMBL
NCBI Gene Igf2 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR II UniProtKB/TrEMBL
  INSULIN-LIKE GROWTH FACTOR II UniProtKB/TrEMBL
Pfam IGF2_C UniProtKB/TrEMBL
  Insulin UniProtKB/TrEMBL
PRINTS INSLNLIKEGF UniProtKB/TrEMBL
  INSLNLIKEGF2 UniProtKB/TrEMBL
  INSULINFAMLY UniProtKB/TrEMBL
PROSITE INSULIN UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART IlGF UniProtKB/TrEMBL
Superfamily-SCOP SSF56994 UniProtKB/TrEMBL
UniProt A0A0A7HSI7 ENTREZGENE, UniProtKB/TrEMBL
  G5C2F3_HETGA UniProtKB/TrEMBL