Ptgr1 (prostaglandin reductase 1) - Rat Genome Database

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Gene: Ptgr1 (prostaglandin reductase 1) Heterocephalus glaber
Analyze
Symbol: Ptgr1
Name: prostaglandin reductase 1
RGD ID: 18930920
Description: ENCODES a protein that exhibits 13-lipoxin reductase activity (ortholog); 2-alkenal reductase (NADPH) activity (ortholog); leukotriene B4 12-hydroxy dehydrogenase activity (ortholog); INVOLVED IN alkene metabolic process (ortholog); leukotriene B4 metabolic process (ortholog); lipoxin A4 metabolic process (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Experimental Liver Neoplasms (ortholog); hypertension (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476023,406,085 - 23,433,283 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptgr1Naked Mole-RatExperimental Liver Neoplasms  ISORGD:6211959068941mRNA, protein:increased expression:liverRGDPMID:24853774|REF_RGD_ID:14401713
Ptgr1Naked Mole-Rathypertension  ISORGD:6211959068941mRNA:decreased expression:rostral ventrolateral medulla, paraventricular nucleus of hypothalamus, nucleus of solitary tract (rat)RGDPMID:23172924|REF_RGD_ID:401959217
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptgr1Naked Mole-Ratautism spectrum disorder  ISORGD:7328199068941CTD Direct Evidence: marker/mechanismCTDPMID:35663546


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptgr1Naked Mole-Ratalkene metabolic process  ISORGD:6211959068941 RGDPMID:11524419|REF_RGD_ID:38501077
Ptgr1Naked Mole-Ratleukotriene B4 metabolic process involved_inISORGD:139902139068941 PMID:8394361UniProtPMID:8394361
Ptgr1Naked Mole-Ratleukotriene B4 metabolic process  ISORGD:6211959068941 RGDPMID:9667737|REF_RGD_ID:401959219
Ptgr1Naked Mole-Ratlipoxin A4 metabolic process involved_inISORGD:139902139068941 PMID:11688989UniProtPMID:11688989
Ptgr1Naked Mole-Ratnegative regulation of positive chemotaxis  ISORGD:6211959068941 RGDPMID:9667737|REF_RGD_ID:401959219
Ptgr1Naked Mole-Ratnegative regulation of reactive oxygen species biosynthetic process  ISORGD:6211959068941 RGDPMID:9667737|REF_RGD_ID:401959219
Ptgr1Naked Mole-Ratprostaglandin metabolic process involved_inIEAPANTHER:PTN000190527150520179 TreeGrafterGO_REF:0000118
Ptgr1Naked Mole-Ratresponse to antineoplastic agent  ISORGD:62119590689411,2-dithiole-3-thioneRGDPMID:8968041|REF_RGD_ID:632607

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptgr1Naked Mole-Ratcytoplasm  ISORGD:6211959068941ex vivo light microscopy with immunohistochemistry MMO:0000538RGDPMID:24853774|REF_RGD_ID:14401713
Ptgr1Naked Mole-Ratcytoplasm located_inISORGD:139902139068941 PMID:8394361UniProtPMID:8394361
Ptgr1Naked Mole-Ratcytosol  ISORGD:6211959068941cell fractionation MMO:0000679RGDPMID:9667737|REF_RGD_ID:401959219
Ptgr1Naked Mole-Ratnucleus  ISORGD:6211959068941ex vivo light microscopy with immunohistochemistry MMO:0000538RGDPMID:24853774|REF_RGD_ID:14401713

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptgr1Naked Mole-Rat13-lipoxin reductase activity enablesISORGD:139902139068941 PMID:11688989UniProtPMID:11688989
Ptgr1Naked Mole-Rat15-oxoprostaglandin 13-reductase [NAD(P)+] activity enablesIEAPANTHER:PTN000190527150520179 TreeGrafterGO_REF:0000118
Ptgr1Naked Mole-Rat2-alkenal reductase (NADPH) activity enablesISORGD:7328199068941 PMID:25619643UniProtPMID:25619643
Ptgr1Naked Mole-Rat2-alkenal reductase (NADPH) activity enablesISORGD:6211959068941PMID:11524419UniProtPMID:11524419|REF_RGD_ID:38501077
Ptgr1Naked Mole-Ratleukotriene B4 12-hydroxy dehydrogenase activity enablesISORGD:139902139068941 PMID:8394361, PMID:8576264UniProtPMID:8394361|PMID:8576264
Ptgr1Naked Mole-Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-0560150520179 UniProtGO_REF:0000043
Ptgr1Naked Mole-Ratoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor enablesIEAInterPro:IPR045010150520179 InterProGO_REF:0000002
Ptgr1Naked Mole-Ratprotein binding enablesISOUniProtKB:Q8WXH29068941 PMID:32814053IntActPMID:32814053

PMID:30032202  



Ptgr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476023,406,085 - 23,433,283 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PTGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389111,549,722 - 111,599,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9111,549,722 - 111,599,893 (-)EnsemblGRCh38hg38GRCh38
GRCh379114,312,002 - 114,361,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369113,365,073 - 113,401,532 (-)NCBINCBI36Build 36hg18NCBI36
Build 349111,404,807 - 111,441,266NCBI
Celera984,811,079 - 84,861,206 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef983,911,040 - 83,960,627 (-)NCBIHuRef
CHM1_19114,458,441 - 114,508,602 (-)NCBICHM1_1
T2T-CHM13v2.09123,721,096 - 123,771,025 (-)NCBIT2T-CHM13v2.0
Ptgr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39458,965,590 - 58,987,131 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl458,965,439 - 58,987,119 (-)EnsemblGRCm39 Ensembl
GRCm38458,965,590 - 58,987,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl458,965,439 - 58,987,119 (-)EnsemblGRCm38mm10GRCm38
MGSCv37458,978,462 - 58,999,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36459,059,644 - 59,081,132 (-)NCBIMGSCv36mm8
Celera458,878,602 - 58,900,216 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map432.36NCBI
Ptgr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8578,579,060 - 78,597,671 (-)NCBIGRCr8
mRatBN7.2573,784,000 - 73,802,624 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl573,784,009 - 73,802,666 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx575,685,300 - 75,703,919 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0577,506,913 - 77,525,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0577,479,071 - 77,497,693 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0576,110,746 - 76,129,361 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl576,110,738 - 76,129,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0580,255,192 - 80,273,709 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4577,010,809 - 77,029,326 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1577,015,922 - 77,034,439 (-)NCBI
Celera572,607,043 - 72,625,264 (-)NCBICelera
Cytogenetic Map5q24NCBI
Ptgr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541915,708,456 - 15,739,147 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541915,708,456 - 15,738,774 (+)NCBIChiLan1.0ChiLan1.0
PTGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21127,816,183 - 27,860,132 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1927,824,016 - 27,862,494 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0982,700,541 - 82,739,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19110,862,122 - 110,900,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9110,848,804 - 110,900,829 (-)Ensemblpanpan1.1panPan2
PTGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11166,191,155 - 66,212,075 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1166,191,165 - 66,209,219 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1164,601,934 - 64,622,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01167,324,103 - 67,345,145 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1167,324,105 - 67,345,298 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11165,841,533 - 65,862,116 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01165,864,869 - 65,885,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01166,554,733 - 66,575,785 (-)NCBIUU_Cfam_GSD_1.0
Ptgr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947181,503,868 - 181,535,213 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365591,731,533 - 1,762,671 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365591,731,346 - 1,762,676 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,373,282 - 252,395,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,373,272 - 252,395,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21283,170,868 - 283,177,809 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103219015
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11227,918,990 - 27,999,736 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603514,779,257 - 14,799,467 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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RefSeq Acc Id: XM_004849647   ⟹   XP_004849704
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476023,406,085 - 23,433,283 (+)NCBI
Protein RefSeqs XP_004849704 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000019774
RefSeq Acc Id: XP_004849704   ⟸   XM_004849647
- UniProtKB: A0AAX6PE84 (UniProtKB/TrEMBL)



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000014158 ENTREZGENE
Ensembl Transcript ENSHGLT00000019972 ENTREZGENE
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro ADH_N_2 UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/TrEMBL
  MDR_fam UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene Ptgr1 ENTREZGENE
PANTHER PROSTAGLANDIN REDUCTASE UniProtKB/TrEMBL
  PROSTAGLANDIN REDUCTASE 1 UniProtKB/TrEMBL
Pfam ADH_N_2 UniProtKB/TrEMBL
Superfamily-SCOP GroES-like UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL
UniProt A0AAX6PE84 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows