PTGR1 (prostaglandin reductase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PTGR1 (prostaglandin reductase 1) Canis lupus familiaris
Analyze
Symbol: PTGR1
Name: prostaglandin reductase 1
RGD ID: 12247046
Description: ENCODES a protein that exhibits 13-lipoxin reductase activity (ortholog); leukotriene B4 12-hydroxy dehydrogenase activity (ortholog); INVOLVED IN cellular alkene metabolic process (ortholog); leukotriene B4 metabolic process (ortholog); lipoxin A4 metabolic process (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Experimental Liver Neoplasms (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leukotriene B4 12-hydroxydehydrogenase; LTB4DH
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11166,191,155 - 66,212,075 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1166,191,165 - 66,209,219 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1164,601,934 - 64,622,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01167,324,103 - 67,345,145 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1167,324,105 - 67,345,298 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11165,841,533 - 65,862,116 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01165,864,869 - 65,885,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01166,554,733 - 66,575,785 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (ISO)
nucleus  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11166,191,155 - 66,212,075 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1166,191,165 - 66,209,219 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1164,601,934 - 64,622,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01167,324,103 - 67,345,145 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1167,324,105 - 67,345,298 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11165,841,533 - 65,862,116 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01165,864,869 - 65,885,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01166,554,733 - 66,575,785 (-)NCBIUU_Cfam_GSD_1.0
PTGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389111,549,722 - 111,599,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9111,549,722 - 111,599,893 (-)EnsemblGRCh38hg38GRCh38
GRCh379114,312,002 - 114,361,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369113,365,073 - 113,401,532 (-)NCBINCBI36Build 36hg18NCBI36
Build 349111,404,807 - 111,441,266NCBI
Celera984,811,079 - 84,861,206 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef983,911,040 - 83,960,627 (-)NCBIHuRef
CHM1_19114,458,441 - 114,508,602 (-)NCBICHM1_1
T2T-CHM13v2.09123,721,096 - 123,771,025 (-)NCBIT2T-CHM13v2.0
Ptgr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39458,965,590 - 58,987,131 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl458,965,439 - 58,987,119 (-)EnsemblGRCm39 Ensembl
GRCm38458,965,590 - 58,987,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl458,965,439 - 58,987,119 (-)EnsemblGRCm38mm10GRCm38
MGSCv37458,978,462 - 58,999,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36459,059,644 - 59,081,132 (-)NCBIMGSCv36mm8
Celera458,878,602 - 58,900,216 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map432.36NCBI
Ptgr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8578,579,060 - 78,597,671 (-)NCBIGRCr8
mRatBN7.2573,784,000 - 73,802,624 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl573,784,009 - 73,802,666 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx575,685,300 - 75,703,919 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0577,506,913 - 77,525,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0577,479,071 - 77,497,693 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0576,110,746 - 76,129,361 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl576,110,738 - 76,129,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0580,255,192 - 80,273,709 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4577,010,809 - 77,029,326 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1577,015,922 - 77,034,439 (-)NCBI
Celera572,607,043 - 72,625,264 (-)NCBICelera
Cytogenetic Map5q24NCBI
Ptgr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541915,708,456 - 15,739,147 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541915,708,456 - 15,738,774 (+)NCBIChiLan1.0ChiLan1.0
PTGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21127,816,183 - 27,860,132 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1927,824,016 - 27,862,494 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0982,700,541 - 82,739,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19110,862,122 - 110,900,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9110,848,804 - 110,900,829 (-)Ensemblpanpan1.1panPan2
Ptgr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947181,503,868 - 181,535,213 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365591,731,533 - 1,762,671 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365591,731,346 - 1,762,676 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,373,282 - 252,395,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,373,272 - 252,395,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21283,170,868 - 283,177,809 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11227,918,990 - 27,999,736 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603514,779,257 - 14,799,467 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476023,406,085 - 23,433,283 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTGR1
473 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 20 5 6 5 6 6 10 6
Low 5 2 1 1 6 6 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005626921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005626922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014117918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038490965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038553104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038553105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000004823   ⟹   ENSCAFP00000004469
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1166,191,165 - 66,209,219 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000079878   ⟹   ENSCAFP00000050830
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1166,191,165 - 66,207,757 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845009852   ⟹   ENSCAFP00845007696
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1167,324,105 - 67,343,752 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845009862   ⟹   ENSCAFP00845007701
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1167,339,274 - 67,345,298 (-)Ensembl
RefSeq Acc Id: XM_005626922   ⟹   XP_005626979
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11166,191,155 - 66,210,860 (-)NCBI
Dog10K_Boxer_Tasha1164,601,934 - 64,621,640 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038490965   ⟹   XP_038346893
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11165,841,533 - 65,862,116 (-)NCBI
RefSeq Acc Id: XM_038553104   ⟹   XP_038409032
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01166,554,733 - 66,575,785 (-)NCBI
RefSeq Acc Id: XM_038553105   ⟹   XP_038409033
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01166,554,733 - 66,574,420 (-)NCBI
RefSeq Acc Id: XM_038616979   ⟹   XP_038472907
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01165,864,869 - 65,885,860 (-)NCBI
RefSeq Acc Id: XM_038616980   ⟹   XP_038472908
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01165,864,869 - 65,884,516 (-)NCBI
RefSeq Acc Id: XM_038653902   ⟹   XP_038509830
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1164,601,934 - 64,622,894 (-)NCBI
RefSeq Acc Id: XM_038682439   ⟹   XP_038538367
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01167,324,103 - 67,345,145 (-)NCBI
RefSeq Acc Id: XM_038682440   ⟹   XP_038538368
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01167,324,103 - 67,343,777 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005626979   ⟸   XM_005626922
- UniProtKB: A0A8C0MR59 (UniProtKB/TrEMBL),   A0A8I3MRC0 (UniProtKB/TrEMBL),   A0A8C0MZC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000004469   ⟸   ENSCAFT00000004823
RefSeq Acc Id: ENSCAFP00000050830   ⟸   ENSCAFT00000079878
RefSeq Acc Id: XP_038346893   ⟸   XM_038490965
RefSeq Acc Id: XP_038472907   ⟸   XM_038616979
RefSeq Acc Id: XP_038472908   ⟸   XM_038616980
RefSeq Acc Id: XP_038538367   ⟸   XM_038682439
- UniProtKB: A0A8C0MR59 (UniProtKB/TrEMBL),   A0A8I3MRC0 (UniProtKB/TrEMBL),   A0A8C0MZC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038538368   ⟸   XM_038682440
- UniProtKB: A0A8C0MR59 (UniProtKB/TrEMBL),   A0A8I3MRC0 (UniProtKB/TrEMBL),   A0A8C0MZC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509830   ⟸   XM_038653902
- UniProtKB: A0A8C0MR59 (UniProtKB/TrEMBL),   A0A8I3MRC0 (UniProtKB/TrEMBL),   A0A8C0MZC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038409032   ⟸   XM_038553104
- UniProtKB: A0A8C0MR59 (UniProtKB/TrEMBL),   A0A8C0MZC4 (UniProtKB/TrEMBL),   A0A8I3MRC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038409033   ⟸   XM_038553105
- UniProtKB: A0A8C0MR59 (UniProtKB/TrEMBL),   A0A8C0MZC4 (UniProtKB/TrEMBL),   A0A8I3MRC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845007701   ⟸   ENSCAFT00845009862
RefSeq Acc Id: ENSCAFP00845007696   ⟸   ENSCAFT00845009852
Protein Domains
Enoyl reductase (ER)   Oxidoreductase N-terminal

Promoters
RGD ID:13685299
Promoter ID:EPDNEW_C3367
Type:single initiation site
Name:PTGR1_1
Description:prostaglandin reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11166,209,222 - 66,209,282EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003000 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008504 UniProtKB/TrEMBL
  ENSCAFG00845005537 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004823.5 UniProtKB/TrEMBL
  ENSCAFT00000110192.1 UniProtKB/TrEMBL
  ENSCAFT00030015631.1 UniProtKB/TrEMBL
  ENSCAFT00030015706.1 UniProtKB/TrEMBL
  ENSCAFT00845009852 ENTREZGENE
  ENSCAFT00845009852.1 UniProtKB/TrEMBL
  ENSCAFT00845009862.1 UniProtKB/TrEMBL
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro ADH_C UniProtKB/TrEMBL
  ADH_N_2 UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/TrEMBL
  MDR_fam UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  PKS_ER UniProtKB/TrEMBL
  PTGR1 UniProtKB/TrEMBL
KEGG Report cfa:474802 UniProtKB/TrEMBL
NCBI Gene PTGR1 ENTREZGENE
PANTHER PROSTAGLANDIN REDUCTASE 1 UniProtKB/TrEMBL
  PTHR43205 UniProtKB/TrEMBL
Pfam ADH_N_2 UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/TrEMBL
SMART PKS_ER UniProtKB/TrEMBL
Superfamily-SCOP SSF50129 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A8C0MR59 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0MZC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MRC0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RSQ9_CANLF UniProtKB/TrEMBL
  A0A8P0TTA0_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:45150 ENTREZGENE