Dnmt1 (DNA methyltransferase 1) - Rat Genome Database

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Gene: Dnmt1 (DNA methyltransferase 1) Heterocephalus glaber
Analyze
Symbol: Dnmt1
Name: DNA methyltransferase 1
RGD ID: 18919505
Description: ENCODES a protein that exhibits DNA (cytosine-5-)-methyltransferase activity (ortholog); DNA-methyltransferase activity (ortholog); histone deacetylase binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); cellular response to lead ion (ortholog); PARTICIPATES IN DNA modification pathway; glycine N-methyltransferase deficiency pathway; homocysteine metabolic pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenocarcinoma (ortholog); alopecia areata (ortholog); FOUND IN female germ cell nucleus (ortholog); germ cell nucleus (ortholog); heterochromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA (cytosine-5)-methyltransferase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,315,251 - 2,358,711 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,316,042 - 2,358,866 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
alopecia areata  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
Ataxia  (ISO)
autism spectrum disorder  (ISO)
autoimmune disease  (ISO)
autosomal dominant cerebellar ataxia, deafness and narcolepsy  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
Binge Drinking  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
Carcinogenesis  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
cerebellar ataxia  (ISO)
Charcot-Marie-Tooth disease  (ISO)
choline deficiency disease  (ISO)
choreatic disease  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
dementia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
endometriosis of uterus  (ISO)
Experimental Arthritis  (ISO)
familial hypercholesterolemia  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
genetic disease  (ISO)
Graves' disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
hereditary sensory neuropathy  (ISO)
hereditary sensory neuropathy type 1E  (ISO)
hypertrophic cardiomyopathy  (ISO)
immunodeficiency 35  (ISO)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
medulloblastoma  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
middle cerebral artery infarction  (ISO)
mucoepidermoid carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Invasiveness  (ISO)
Oral Lichen Planus  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Intraepithelial Neoplasia  (ISO)
Peritoneal Fibrosis  (ISO)
Pituitary Stalk Interruption Syndrome  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
sleep disorder  (ISO)
spastic ataxia  (ISO)
Spastic Paraparesis  (ISO)
Stomach Neoplasms  (ISO)
systemic lupus erythematosus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (ISO)
cellular response to bisphenol A  (ISO)
cellular response to lead ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromosomal DNA methylation maintenance following DNA replication  (ISO)
DNA methylation-dependent constitutive heterochromatin formation  (IEA)
DNA-templated transcription  (ISO)
epigenetic programming of gene expression  (ISO)
methylation  (IEA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gene expression via chromosomal CpG island methylation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (ISO)
neuron differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of gene expression  (ISO)
response to activity  (ISO)
response to alcohol  (ISO)
response to bisphenol A  (ISO)
response to caffeine  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to ionizing radiation  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to testosterone  (ISO)
response to toxic substance  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dnmt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,315,251 - 2,358,711 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,316,042 - 2,358,866 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DNMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,133,346 - 10,194,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,133,342 - 10,231,286 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,244,022 - 10,305,629 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,105,022 - 10,166,811 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,105,022 - 10,166,811NCBI
Celera1910,139,454 - 10,201,147 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,824,670 - 9,886,268 (-)NCBIHuRef
CHM1_11910,244,307 - 10,306,021 (-)NCBICHM1_1
T2T-CHM13v2.01910,259,569 - 10,321,116 (-)NCBIT2T-CHM13v2.0
Dnmt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,818,501 - 20,871,084 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,818,505 - 20,871,184 (-)EnsemblGRCm39 Ensembl
GRCm38920,907,206 - 20,959,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,907,209 - 20,959,888 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,711,653 - 20,757,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,657,611 - 20,703,267 (-)NCBIMGSCv36mm8
Celera918,175,907 - 18,221,569 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.66NCBI
Dnmt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,716,797 - 27,763,405 (-)NCBIGRCr8
mRatBN7.2819,440,611 - 19,486,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,440,611 - 19,486,659 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,459,969 - 23,505,932 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,757,816 - 21,803,779 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,670,294 - 19,716,334 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,922,515 - 21,968,495 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,922,515 - 21,968,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,978,830 - 22,024,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,926,995 - 19,973,256 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1819,927,666 - 19,973,220 (-)NCBI
Celera820,835,612 - 20,881,380 (-)NCBICelera
Cytogenetic Map8q13NCBI
Dnmt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,465,480 - 1,505,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,465,529 - 1,505,379 (-)NCBIChiLan1.0ChiLan1.0
DNMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,048,374 - 15,112,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,048,694 - 14,110,457 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,681,847 - 9,745,334 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,342,478 - 10,390,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,342,478 - 10,406,972 (-)Ensemblpanpan1.1panPan2
DNMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,872,213 - 50,928,352 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,879,527 - 50,928,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,741,748 - 50,797,884 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,393,895 - 51,450,128 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,401,720 - 51,450,127 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,599,735 - 50,657,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,028,945 - 51,085,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,269,676 - 51,325,956 (+)NCBIUU_Cfam_GSD_1.0
Dnmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,789,213 - 209,834,531 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659520,493 - 565,416 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659520,181 - 565,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,981,566 - 69,029,844 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1268,981,564 - 69,040,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,309,511 - 69,357,838 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,199,006 - 9,263,890 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,199,003 - 9,263,607 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,795,260 - 10,857,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000025872   ⟹   ENSHGLP00000025645
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248282,315,251 - 2,358,711 (-)Ensembl
RefSeq Acc Id: XM_004865481   ⟹   XP_004865538
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,316,042 - 2,358,866 (-)NCBI
RefSeq Acc Id: XM_013065937   ⟹   XP_012921391
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,316,042 - 2,358,866 (-)NCBI
RefSeq Acc Id: XM_013065938   ⟹   XP_012921392
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,316,042 - 2,358,865 (-)NCBI
RefSeq Acc Id: XM_021245075   ⟹   XP_021100734
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,316,042 - 2,342,822 (-)NCBI
RefSeq Acc Id: XM_021245076   ⟹   XP_021100735
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,316,042 - 2,341,922 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004865538 (Get FASTA)   NCBI Sequence Viewer  
  XP_012921391 (Get FASTA)   NCBI Sequence Viewer  
  XP_012921392 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100734 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100735 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000025645
RefSeq Acc Id: XP_012921391   ⟸   XM_013065937
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QMV4 (UniProtKB/TrEMBL),   G5B344 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004865538   ⟸   XM_004865481
- Peptide Label: isoform X1
- UniProtKB: A0AAX6Q5Q3 (UniProtKB/TrEMBL),   G5B344 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012921392   ⟸   XM_013065938
- Peptide Label: isoform X3
- UniProtKB: A0AAX6QJ33 (UniProtKB/TrEMBL),   G5B344 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100734   ⟸   XM_021245075
- Peptide Label: isoform X4
- UniProtKB: A0AAX6RW83 (UniProtKB/TrEMBL),   G5B344 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100735   ⟸   XM_021245076
- Peptide Label: isoform X5
- UniProtKB: A0AAX6RZD5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000025645   ⟸   ENSHGLT00000025872


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018262 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000025872 ENTREZGENE
Gene3D-CATH 1.10.10.2230 UniProtKB/TrEMBL
  2.30.30.490 UniProtKB/TrEMBL
  DNA Methylase, subunit A, domain 2 UniProtKB/TrEMBL
  Vaccinia Virus protein VP39 UniProtKB/TrEMBL
InterPro BAH_dom UniProtKB/TrEMBL
  BAH_sf UniProtKB/TrEMBL
  C5-Methyltransferase UniProtKB/TrEMBL
  C5_DNA_meth_AS UniProtKB/TrEMBL
  C5_MeTfrase UniProtKB/TrEMBL
  C5_meth_CS UniProtKB/TrEMBL
  Cytosine_MeTrfase1_RFD UniProtKB/TrEMBL
  DMAP1-bd UniProtKB/TrEMBL
  DNMT1-like UniProtKB/TrEMBL
  SAM-dependent_MTases_sf UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/TrEMBL
NCBI Gene Dnmt1 ENTREZGENE
PANTHER CYTOSINE-SPECIFIC METHYLTRANSFERASE UniProtKB/TrEMBL
  DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 UniProtKB/TrEMBL
Pfam BAH UniProtKB/TrEMBL
  DMAP_binding UniProtKB/TrEMBL
  DNA_methylase UniProtKB/TrEMBL
  DNMT1-RFD UniProtKB/TrEMBL
  zf-CXXC UniProtKB/TrEMBL
PIRSF DNMT1 UniProtKB/TrEMBL
PRINTS C5METTRFRASE UniProtKB/TrEMBL
PROSITE BAH UniProtKB/TrEMBL
  C5_MTASE_1 UniProtKB/TrEMBL
  C5_MTASE_2 UniProtKB/TrEMBL
  DMAP1_BIND UniProtKB/TrEMBL
  SAM_MT_C5 UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/TrEMBL
SMART BAH UniProtKB/TrEMBL
  DMAP_binding UniProtKB/TrEMBL
Superfamily-SCOP S-adenosyl-L-methionine-dependent methyltransferases UniProtKB/TrEMBL
UniProt A0AAX6Q5Q3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QJ33 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QMV4 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RW83 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RZD5 ENTREZGENE, UniProtKB/TrEMBL
  G5B344 ENTREZGENE, UniProtKB/TrEMBL