Ctla4 (cytotoxic T-lymphocyte associated protein 4) - Rat Genome Database

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Gene: Ctla4 (cytotoxic T-lymphocyte associated protein 4) Heterocephalus glaber
Analyze
Symbol: Ctla4
Name: cytotoxic T-lymphocyte associated protein 4
RGD ID: 18924354
Description: INVOLVED IN DNA damage response (ortholog); negative regulation of B cell proliferation (ortholog); negative regulation of T cell proliferation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); adult T-cell leukemia/lymphoma (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN clathrin-coated endocytic vesicle (ortholog); Golgi apparatus (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Cytotoxic T-lymphocyte protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476512,449,205 - 12,454,324 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476512,449,205 - 12,454,324 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic rhinitis  (ISO)
alopecia areata  (ISO)
Alstrom syndrome  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
Asparagine Synthetase Deficiency  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autoimmune hemolytic anemia  (ISO)
autoimmune hepatitis  (ISO)
Autoimmune Hypothyroidism  (ISO)
autoimmune lymphoproliferative syndrome type 2B  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type V  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
celiac disease  (ISO)
Chronic Bronchitis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
common variable immunodeficiency 1  (ISO)
contact dermatitis  (ISO)
Cryptogenic Cirrhosis  (ISO)
Diabetic Nephropathies  (ISO)
end stage renal disease  (ISO)
Enterocolitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Melanoma  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
hepatitis A  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
immunoglobulin alpha deficiency  (ISO)
Inflammation  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
latent autoimmune diabetes in adults  (ISO)
lung disease  (ISO)
lupus nephritis  (ISO)
Lymphadenopathy  (ISO)
Lymphatic Metastasis  (ISO)
malaria  (ISO)
melanoma  (ISO)
monoclonal gammopathy of uncertain significance  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (ISO)
Neurodevelopmental Disorders  (ISO)
non-Hodgkin lymphoma  (ISO)
oral submucous fibrosis  (ISO)
peripheral nervous system disease  (ISO)
primary biliary cholangitis  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
primary immunodeficiency disease  (ISO)
primary pulmonary hypertension  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 12  (ISO)
urinary schistosomiasis  (ISO)
vitiligo  (ISO)

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ctla4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476512,449,205 - 12,454,324 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476512,449,205 - 12,454,324 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CTLA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382203,867,771 - 203,873,965 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2203,853,888 - 203,873,965 (+)EnsemblGRCh38hg38GRCh38
GRCh372204,732,494 - 204,738,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362204,440,754 - 204,446,928 (+)NCBINCBI36Build 36hg18NCBI36
Build 342204,558,016 - 204,564,189NCBI
Celera2198,487,330 - 198,493,462 (+)NCBICelera
Cytogenetic Map2q33.2NCBI
HuRef2196,579,809 - 196,585,939 (+)NCBIHuRef
CHM1_12204,739,066 - 204,745,196 (+)NCBICHM1_1
T2T-CHM13v2.02204,349,656 - 204,355,847 (+)NCBIT2T-CHM13v2.0
Ctla4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,948,184 - 60,954,991 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl160,926,159 - 60,954,991 (+)EnsemblGRCm39 Ensembl
GRCm38160,909,025 - 60,915,832 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,887,000 - 60,915,832 (+)EnsemblGRCm38mm10GRCm38
MGSCv37160,965,869 - 60,972,674 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36160,853,571 - 60,860,376 (+)NCBIMGSCv36mm8
Celera161,424,040 - 61,430,841 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.58NCBI
Ctla4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8969,812,859 - 69,819,959 (+)NCBIGRCr8
mRatBN7.2962,318,874 - 62,325,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl962,319,312 - 62,324,963 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx970,821,431 - 70,826,972 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0975,937,041 - 75,942,584 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0974,255,613 - 74,261,154 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0967,699,397 - 67,706,068 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,699,379 - 67,706,065 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0967,509,236 - 67,515,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4959,495,773 - 59,501,300 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1959,642,754 - 59,648,282 (+)NCBI
Celera959,742,231 - 59,747,758 (+)NCBICelera
Cytogenetic Map9q32NCBI
Ctla4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545711,028,698 - 11,073,460 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545711,028,707 - 11,034,898 (-)NCBIChiLan1.0ChiLan1.0
CTLA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213106,472,380 - 106,478,722 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B106,487,372 - 106,493,704 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B91,054,917 - 91,106,234 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B209,239,417 - 209,244,498 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B209,239,417 - 209,244,498 (+)Ensemblpanpan1.1panPan2
CTLA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13712,647,712 - 12,653,874 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3712,634,563 - 12,653,874 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3713,530,863 - 13,537,025 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03712,584,278 - 12,590,425 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3712,528,644 - 12,590,422 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13712,541,354 - 12,547,516 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03712,504,724 - 12,510,894 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03712,505,745 - 12,511,890 (+)NCBIUU_Cfam_GSD_1.0
Ctla4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303160,849,279 - 160,854,996 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936631484,356 - 489,643 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936631484,356 - 489,643 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTLA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15107,282,927 - 107,289,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115107,283,081 - 107,288,041 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215118,627,675 - 118,632,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTLA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11089,637,176 - 89,644,436 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1089,638,314 - 89,642,344 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040109,742,081 - 109,748,529 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000012883   ⟹   ENSHGLP00000012746
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476512,449,205 - 12,454,324 (-)Ensembl
RefSeq Acc Id: XM_004851172   ⟹   XP_004851229
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476512,449,205 - 12,454,324 (-)NCBI
RefSeq Acc Id: XM_004851173   ⟹   XP_004851230
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476512,449,248 - 12,454,324 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004851229 (Get FASTA)   NCBI Sequence Viewer  
  XP_004851230 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB09853 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000012746
RefSeq Acc Id: XP_004851229   ⟸   XM_004851172
- Peptide Label: isoform X1
- UniProtKB: G5BKP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004851230   ⟸   XM_004851173
- Peptide Label: isoform X2
- UniProtKB: A0AAX6PG99 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000012746   ⟸   ENSHGLT00000012883


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009115 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000012883 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro CTLA4 UniProtKB/TrEMBL
  CTLA4/CD28 UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report hgl:101722788 UniProtKB/TrEMBL
NCBI Gene Ctla4 ENTREZGENE
PANTHER PTHR11494 UniProtKB/TrEMBL
  PTHR11494:SF8 UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PRINTS CTLANTIGEN4 UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0AAX6PG99 ENTREZGENE, UniProtKB/TrEMBL
  G5BKP2 ENTREZGENE, UniProtKB/TrEMBL