RGD Reference Report - Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. - Rat Genome Database

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Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat.

Authors: Maeda, Y  Taira, T  Haraguchi, K  Hirose, K  Kazusaka, A  Fujita, S 
Citation: Maeda Y, etal., Cancer Lett. 1997 Nov 11;119(2):137-41.
RGD ID: 1581428
Pubmed: PMID:9570363   (View Abstract at PubMed)

We have studied the DNA binding activities of transcription factors in the liver of Long-Evans Cinnamon (LEC) rats, an animal model of Wilson's disease. Owing to a genetic defect, this strain of rats accumulates excessive copper in the liver and develops severe hepatitis and hepatocellular carcinoma. We found that the DNA binding activity of the serum response factor (SRF) was higher in the liver of LEC rats (approximately 2-fold) than in that of Wistar rats. There was a close correlation between the intensity of the activity and the concentrations of copper in the nuclear protein. The DNA binding activity of Sp1, on the other hand, showed similar levels in both LEC and Wistar rats. SRF may play an important role in the development of hepatocellular carcinoma in LEC rats by mediating the proto-oncogene c-fos induction. We suggest that the copper in nuclear protein may be involved in the activation of SRF.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SRFHumanhepatocellular carcinoma  ISOSrf (Rattus norvegicus) RGD 
SrfMousehepatocellular carcinoma  ISOSrf (Rattus norvegicus) RGD 
SrfRathepatocellular carcinoma  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Srf  (serum response factor)

Genes (Mus musculus)
Srf  (serum response factor)

Genes (Homo sapiens)
SRF  (serum response factor)


Additional Information