SRF (serum response factor) - Rat Genome Database

Name: SRF
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: SRF (serum response factor) Homo sapiens

Analyze

Symbol:

SRF

Name:

serum response factor

RGD ID:

1321393

HGNC Page

HGNC:11291

Description:

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; protein homodimerization activity; and serum response element binding activity. Involved in several processes, including circulatory system development; negative regulation of amyloid-beta clearance; and regulation of DNA-templated transcription. Acts upstream of or within positive regulation of cell differentiation; positive regulation of transcription by RNA polymerase II; and trophectodermal cell differentiation. Located in nucleus. Implicated in cardiomyopathy and lymphangioleiomyomatosis. Biomarker of congestive heart failure and lymphangioleiomyomatosis.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

c-fos serum response element-binding transcription factor; MCM1; minichromosome maintenance 1 homolog; serum response factor (c-fos serum response element-binding transcription factor)

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Srf (serum response factor)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Srf (serum response factor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Srf (serum response factor)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	SRF (serum response factor)	NCBI	Ortholog
Canis lupus familiaris (dog):	SRF (serum response factor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Srf (serum response factor)	NCBI	Ortholog
Sus scrofa (pig):	SRF (serum response factor)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	SRF (serum response factor)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Srf (serum response factor)	NCBI	Ortholog
Alliance orthologs ³
Mus musculus (house mouse):	Srf (serum response factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Srf (serum response factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	srfb (serum response factor b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB\|ZFIN)
Danio rerio (zebrafish):	srfa (serum response factor a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	ARG80	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	bs	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	unc-120	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	MCM1	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	43,171,269 - 43,181,506 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	43,171,269 - 43,181,506 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	43,139,007 - 43,149,244 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	43,246,898 - 43,257,222 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	43,247,014 - 43,257,221	NCBI
Celera	6	44,691,142 - 44,701,465 (+)	NCBI		Celera
Cytogenetic Map	6	p21.1	NCBI
HuRef	6	42,855,575 - 42,865,934 (+)	NCBI		HuRef
CHM1_1	6	43,141,808 - 43,152,132 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	43,000,031 - 43,010,279 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiomegaly (IDA)

cardiomyopathy (IDA)

Cardiovascular Abnormalities (ISO)

congestive heart failure (IEP)

dilated cardiomyopathy (ISO,ISS)

disease of cellular proliferation (EXP)

hepatocellular carcinoma (ISO)

human immunodeficiency virus infectious disease (EXP)

hypertension (ISO)

lymphangioleiomyomatosis (IDA,IEP)

Neoplasm Metastasis (HDA)

pancreatitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-anisomycin (EXP)

(S)-amphetamine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-butoxyethanol (ISO)

2-hydroxypropanoic acid (EXP)

2-methylcholine (EXP)

3-Nitrobenzanthrone (EXP)

8-(4-chlorophenylthio)-cGMP (EXP)

8-bromo-3',5'-cyclic GMP (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP)

aristolochic acid A (EXP)

arsenous acid (EXP)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

butanal (EXP)

C60 fullerene (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP)

cadmium sulfate (EXP)

caffeine (EXP)

chlorpyrifos (ISO)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

cyclosporin A (EXP)

diarsenic trioxide (EXP)

diazinon (EXP)

dibutyl phthalate (ISO)

dioxygen (ISO)

endosulfan (EXP,ISO)

ethanol (ISO)

folic acid (ISO)

gentamycin (ISO)

hydrogen peroxide (EXP)

jaspamide (EXP)

latrunculin B (EXP)

lead(0) (EXP)

lead(2+) (EXP)

lead(II) chloride (EXP)

leflunomide (EXP,ISO)

mangiferin (ISO)

mercury atom (EXP)

mercury(0) (EXP)

morphine (ISO)

paracetamol (ISO)

phencyclidine (ISO)

rac-lactic acid (EXP)

resveratrol (EXP,ISO)

rotenone (ISO)

SB 203580 (EXP)

sodium arsenite (EXP)

Soman (ISO)

tert-butyl hydroperoxide (EXP)

thioacetamide (ISO)

trichloroethene (ISO)

trimethyltin (ISO)

valproic acid (EXP)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO,ISS)

actin filament organization (IEA,ISO)

angiogenesis involved in wound healing (TAS)

animal organ development (IEA)

associative learning (IEA,ISO)

axon extension (IEA,ISO)

bicellular tight junction assembly (IEA,ISO)

branching involved in blood vessel morphogenesis (IEA,ISO)

bronchus cartilage development (IEA,ISO)

cardiac muscle cell myoblast differentiation (IEA,IGI)

cardiac myofibril assembly (IEA,ISO)

cardiac vascular smooth muscle cell differentiation (IEA,ISO)

cell migration involved in sprouting angiogenesis (IEA,IMP,ISO)

cell-cell adhesion (IEA,ISO)

cell-matrix adhesion (IEA,ISO)

cellular response to glucose stimulus (IEA,ISO)

cellular senescence (IMP)

contractile actin filament bundle assembly (IEA,ISO)

developmental growth (IEA,ISO)

DNA-templated transcription (IEA)

dorsal aorta morphogenesis (IEA,ISO)

epithelial cell-cell adhesion (IEA,ISO)

epithelial structure maintenance (IEA,ISO)

erythrocyte development (IEA,ISO)

establishment of skin barrier (ISO)

eyelid development in camera-type eye (IEA,ISO)

face development (IEA,ISO)

filopodium assembly (IEA,ISO)

forebrain development (IEA,ISO)

gastrulation (IEA,ISO)

heart development (IEA,ISO,ISS)

heart looping (IEA,ISO,ISS)

heart trabecula formation (IEA,ISO)

hematopoietic stem cell differentiation (IEA,ISO)

hippocampus development (IEA,ISO)

in utero embryonic development (IEA,ISO)

leukocyte differentiation (IEA,ISO)

long-term memory (IEA,ISO)

long-term synaptic depression (IEA,ISO)

lung morphogenesis (IEA,ISO)

lung smooth muscle development (IEA,ISO)

megakaryocyte development (IEA,ISO)

mesoderm formation (IEA,ISO)

morphogenesis of an epithelial sheet (IEA,ISO)

muscle cell cellular homeostasis (IEA,ISO,ISS)

negative regulation of amyloid-beta clearance (IMP)

negative regulation of cell migration (IEA,ISO)

negative regulation of cell population proliferation (IEA,ISO)

negative regulation of miRNA transcription (IEA,ISS)

neuron development (TAS)

neuron migration (IEA,ISO)

neuron projection development (IEA,ISO)

obsolete positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation (IGI)

obsolete positive regulation of transcription via serum response element binding (IEA)

obsolete regulation of water loss via skin (IEA)

platelet activation (IEA,ISO)

platelet formation (IEA,ISO)

positive regulation of axon extension (IEA,ISO)

positive regulation of cell differentiation (IDA)

positive regulation of DNA-binding transcription factor activity (IDA,IMP)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of filopodium assembly (IEA,ISO)

positive regulation of miRNA transcription (IEA,IGI,ISS)

positive regulation of smooth muscle contraction (IDA)

positive regulation of transcription by glucose (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IBA,IDA,IEA,IGI,ISS)

positive regulation of transcription initiation by RNA polymerase II (IDA)

positive thymic T cell selection (IEA,ISO)

primitive streak formation (IEA,ISO)

regulation of cell adhesion (IEA,ISO)

regulation of DNA-templated transcription (IEA,ISO)

regulation of smooth muscle cell differentiation (TAS)

regulation of transcription by RNA polymerase II (IBA)

response to cytokine (IMP,NAS)

response to hormone (IDA)

response to hypoxia (IEP)

response to toxic substance (TAS)

sarcomere organization (IEA,ISO)

skin morphogenesis (IEA,ISO)

stress fiber assembly (IEA,ISO)

tangential migration from the subventricular zone to the olfactory bulb (IEA,ISO)

thymus development (IEA,ISO)

thyroid gland development (IEA,ISO)

trachea cartilage development (IEA,ISO)

transcription by RNA polymerase II (IEA,ISO)

trophectodermal cell differentiation (IDA)

Cellular Component

chromatin (IEA)

cytoplasm (IEA,TAS)

nucleoplasm (TAS)

nucleus (IDA,IEA,ISO)

Molecular Function

chromatin binding (IEA)

chromatin DNA binding (IEA)

cis-regulatory region sequence-specific DNA binding (IEA)

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IDA,IEA,IGI,ISS)

DNA-binding transcription factor activity (IDA,IEA,IMP)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

DNA-binding transcription factor binding (IPI)

histone deacetylase binding (IEA,ISO)

primary miRNA binding (IEA,ISS)

protein binding (IPI,ISO)

protein dimerization activity (IEA)

protein homodimerization activity (IPI)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IDA,IEA,ISS)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IDA)

serum response element binding (IBA,IDA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

mitogen activated protein kinase signaling pathway (IEA)

platelet-derived growth factor signaling pathway (EXP)

References

References - curated

#	Reference Title	Reference Citation
1.	Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading.	Chang J, etal., Circulation. 2003 Jul 29;108(4):407-13. Epub 2003 Jul 21.
2.	Increased expression of alternatively spliced dominant-negative isoform of SRF in human failing hearts.	Davis FJ, etal., Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1521-33.
3.	A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context.	Etkin A, etal., Neuron. 2006 Apr 6;50(1):127-43.
4.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
5.	Increased Myosin Light Chain Kinase Expression in Hypertension: Regulation by SRF via an Insertion Mutation in the Promoter.	Han YJ, etal., Mol Biol Cell. 2006 Jul 5;.
6.	Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis.	Liu Z, etal., Clin Cancer Res. 2014 Sep 1;20(17):4598-612. doi: 10.1158/1078-0432.CCR-13-3380. Epub 2014 Jul 9.
7.	Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat.	Maeda Y, etal., Cancer Lett. 1997 Nov 11;119(2):137-41.
8.	Restricted inactivation of serum response factor to the cardiovascular system.	Miano JM, etal., Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17132-7. Epub 2004 Nov 29.
9.	Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis.	Miralles F, etal., Lab Invest. 2006 Oct;86(10):1020-36. Epub 2006 Aug 7.
10.	Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart.	Parlakian A, etal., Circulation. 2005 Nov 8;112(19):2930-9. Epub 2005 Oct 31.
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Model of functional cardiac aging: young adult mice with mild overexpression of serum response factor.	Zhang X, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R552-60.
15.	Tissue inhibitor of metalloproteinase-3 downregulation in lymphangioleiomyomatosis: potential consequence of abnormal serum response factor expression.	Zhe X, etal., Am J Respir Cell Mol Biol. 2003 Apr;28(4):504-11.

Additional References at PubMed

PMID:1509260	PMID:1512232	PMID:1547771	PMID:1740119	PMID:2046671	PMID:2108863	PMID:3203386	PMID:7540136	PMID:7551568	PMID:7624133	PMID:7637780	PMID:7744019
PMID:7796532	PMID:7854423	PMID:8024585	PMID:8083237	PMID:8106390	PMID:8375385	PMID:8407951	PMID:8413226	PMID:8604338	PMID:8617811	PMID:8670842	PMID:8887666
PMID:9010223	PMID:9032301	PMID:9271374	PMID:9334314	PMID:9388250	PMID:9545312	PMID:9584171	PMID:9786846	PMID:10082523	PMID:10318842	PMID:10318869	PMID:10336466
PMID:10556093	PMID:10571058	PMID:10606656	PMID:10753652	PMID:10777532	PMID:10847592	PMID:10993896	PMID:11003651	PMID:11104785	PMID:11136726	PMID:11158291	PMID:11181183
PMID:11278942	PMID:11359793	PMID:11387340	PMID:11406578	PMID:11439182	PMID:11457859	PMID:11500490	PMID:11641790	PMID:11846562	PMID:11859076	PMID:12061776	PMID:12077347
PMID:12082086	PMID:12171911	PMID:12200418	PMID:12242287	PMID:12270917	PMID:12297045	PMID:12397177	PMID:12477932	PMID:12530967	PMID:12622724	PMID:12660819	PMID:12663674
PMID:12788062	PMID:12788374	PMID:12853125	PMID:14565952	PMID:15014501	PMID:15180964	PMID:15207639	PMID:15282327	PMID:15326221	PMID:15456770	PMID:15489334	PMID:15492011
PMID:15542842	PMID:15576363	PMID:15591049	PMID:15610731	PMID:15802564	PMID:15806162	PMID:15857835	PMID:15862967	PMID:16054032	PMID:16151017	PMID:16690609	PMID:17081983
PMID:17122890	PMID:17158926	PMID:17200232	PMID:17215356	PMID:17360478	PMID:17376895	PMID:17468179	PMID:17576768	PMID:17599918	PMID:17629633	PMID:17670796	PMID:17975004
PMID:18029348	PMID:18078809	PMID:18296735	PMID:18497331	PMID:18501668	PMID:18694962	PMID:18780286	PMID:19079548	PMID:19098903	PMID:19151320	PMID:19151755	PMID:19198601
PMID:19274049	PMID:19329434	PMID:19342595	PMID:19350017	PMID:19359245	PMID:19513551	PMID:19578358	PMID:19687146	PMID:19724058	PMID:19783823	PMID:19801679	PMID:19913121
PMID:19953255	PMID:20096952	PMID:20144681	PMID:20147408	PMID:20379614	PMID:20628086	PMID:20685657	PMID:20724380	PMID:20808827	PMID:20811705	PMID:21131446	PMID:21393865
PMID:21410985	PMID:21479245	PMID:21777672	PMID:21842128	PMID:21873635	PMID:21893058	PMID:21965288	PMID:21988832	PMID:21998125	PMID:22049076	PMID:22157009	PMID:22192413
PMID:22356487	PMID:22537405	PMID:23134219	PMID:23152437	PMID:23382706	PMID:23382855	PMID:23454662	PMID:23469924	PMID:23576568	PMID:23764775	PMID:24088304	PMID:24173109
PMID:24249383	PMID:24627437	PMID:25080937	PMID:25298399	PMID:25402621	PMID:25681733	PMID:25728840	PMID:25896507	PMID:26100622	PMID:26321231	PMID:26554816	PMID:26671411
PMID:26760575	PMID:26801758	PMID:26823487	PMID:26885614	PMID:27323859	PMID:27350449	PMID:27911586	PMID:28069441	PMID:28112683	PMID:28161397	PMID:28248815	PMID:28249598
PMID:28251884	PMID:28473536	PMID:28611215	PMID:28900514	PMID:29321169	PMID:29400712	PMID:29931229	PMID:29940177	PMID:30365040	PMID:30371874	PMID:30500416	PMID:31478943
PMID:31815603	PMID:32119877	PMID:32187044	PMID:32330601	PMID:32380971	PMID:32885587	PMID:32986930	PMID:33021523	PMID:33226137	PMID:33564100	PMID:33837725	PMID:33978489
PMID:34067464	PMID:34204945	PMID:34373451	PMID:34417138	PMID:36436184

Genomics

Comparative Map Data

SRF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	43,171,269 - 43,181,506 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	43,171,269 - 43,181,506 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	43,139,007 - 43,149,244 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	43,246,898 - 43,257,222 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	43,247,014 - 43,257,221	NCBI
Celera	6	44,691,142 - 44,701,465 (+)	NCBI		Celera
Cytogenetic Map	6	p21.1	NCBI
HuRef	6	42,855,575 - 42,865,934 (+)	NCBI		HuRef
CHM1_1	6	43,141,808 - 43,152,132 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	43,000,031 - 43,010,279 (+)	NCBI		T2T-CHM13v2.0

Srf
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	46,857,764 - 46,869,194 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	46,859,255 - 46,867,101 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	46,546,838 - 46,558,267 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	46,548,329 - 46,556,175 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	46,683,788 - 46,693,111 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	46,010,028 - 46,019,351 (-)	NCBI		MGSCv36	mm8
Celera	17	49,982,837 - 49,992,041 (-)	NCBI		Celera
Cytogenetic Map	17	C	NCBI

Srf
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	14,426,453 - 14,435,734 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	14,426,472 - 14,435,733 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	23,010,176 - 23,019,436 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	28,073,247 - 28,082,508 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	26,373,557 - 26,382,817 (+)	NCBI	Rnor_WKY
Rnor_6.0	9	16,737,637 - 16,747,226 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	16,737,642 - 16,747,225 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	15,642,584 - 15,652,178 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	9,788,378 - 9,797,639 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	12,173,971 - 12,183,234 (+)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

Srf
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	9,098,968 - 9,107,057 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	9,100,546 - 9,109,305 (+)	NCBI	ChiLan1.0	ChiLan1.0

SRF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	44,057,192 - 44,066,768 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	44,057,192 - 44,066,768 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	42,763,099 - 42,773,332 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

SRF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	11,664,441 - 11,673,846 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	11,664,527 - 11,671,533 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	11,691,502 - 11,700,834 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	12,146,868 - 12,156,424 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	12,146,882 - 12,156,417 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	11,674,421 - 11,683,753 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	11,758,840 - 11,768,172 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	11,853,634 - 11,862,966 (+)	NCBI		UU_Cfam_GSD_1.0

Srf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	47,170,709 - 47,180,262 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	16,782,233 - 16,789,130 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936476	16,779,941 - 16,789,499 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	38,213,487 - 38,222,144 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	38,213,300 - 38,223,686 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	43,712,387 - 43,724,048 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SRF
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	28,983,161 - 28,993,465 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	28,983,002 - 28,992,995 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	43,231,123 - 43,241,353 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Srf
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624754	16,371,995 - 16,381,287 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SRF
9 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 6p21.1(chr6:42368558-44590544)x1	copy number loss	See cases [RCV000051011]	Chr6:42368558..44590544 [GRCh38] Chr6:42336296..44558281 [GRCh37] Chr6:42444274..44666259 [NCBI36] Chr6:6p21.1	pathogenic
GRCh38/hg38 6p21.1(chr6:42133625-44106194)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051899]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051899]\|See cases [RCV000051899]	Chr6:42133625..44106194 [GRCh38] Chr6:42101363..44073931 [GRCh37] Chr6:42209341..44181909 [NCBI36] Chr6:6p21.1	pathogenic
GRCh38/hg38 6p21.2-21.1(chr6:37777369-45653843)x1	copy number loss	See cases [RCV000052181]	Chr6:37777369..45653843 [GRCh38] Chr6:37745145..45621580 [GRCh37] Chr6:37853123..45729558 [NCBI36] Chr6:6p21.2-21.1	pathogenic
GRCh38/hg38 6p21.1-12.3(chr6:41638061-46512949)x1	copy number loss	See cases [RCV000052182]	Chr6:41638061..46512949 [GRCh38] Chr6:41605799..46480686 [GRCh37] Chr6:41713777..46588645 [NCBI36] Chr6:6p21.1-12.3	pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3	copy number gain	See cases [RCV000143497]	Chr6:156974..46789291 [GRCh38] Chr6:156974..46757028 [GRCh37] Chr6:101974..46864987 [NCBI36] Chr6:6p25.3-12.3	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3	copy number gain	See cases [RCV000512067]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)	copy number gain	See cases [RCV000510595]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3	copy number gain	not provided [RCV000745400]	Chr6:60107..171054786 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3	copy number gain	not provided [RCV000745403]	Chr6:108666..170980171 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3	copy number gain	not provided [RCV000745404]	Chr6:165632..170919470 [GRCh37] Chr6:6p25.3-q27	pathogenic
NM_003131.4(SRF):c.147G>T (p.Ala49=)	single nucleotide variant	not provided [RCV000951082]	Chr6:43171803 [GRCh38] Chr6:43139541 [GRCh37] Chr6:6p21.1	likely benign
NM_003131.4(SRF):c.384C>T (p.Ser128=)	single nucleotide variant	not provided [RCV000899598]	Chr6:43172040 [GRCh38] Chr6:43139778 [GRCh37] Chr6:6p21.1	benign
NM_003131.4(SRF):c.1354+8G>C	single nucleotide variant	not provided [RCV000880122]	Chr6:43178493 [GRCh38] Chr6:43146231 [GRCh37] Chr6:6p21.1	benign
NM_003131.4(SRF):c.183G>C (p.Ala61=)	single nucleotide variant	not provided [RCV000937493]	Chr6:43171839 [GRCh38] Chr6:43139577 [GRCh37] Chr6:6p21.1	likely benign
NM_003131.4(SRF):c.781-7G>T	single nucleotide variant	not provided [RCV000943443]	Chr6:43175699 [GRCh38] Chr6:43143437 [GRCh37] Chr6:6p21.1	likely benign
NM_003131.4(SRF):c.715A>T (p.Thr239Ser)	single nucleotide variant	not provided [RCV000895873]	Chr6:43174048 [GRCh38] Chr6:43141786 [GRCh37] Chr6:6p21.1	likely benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367)	copy number gain	not provided [RCV000767714]	Chr6:29455465..81447367 [GRCh37] Chr6:6p22.1-q14.1	pathogenic
NM_003131.4(SRF):c.138G>A (p.Gly46=)	single nucleotide variant	not provided [RCV000952906]	Chr6:43171794 [GRCh38] Chr6:43139532 [GRCh37] Chr6:6p21.1	likely benign
NM_003131.4(SRF):c.1422G>T (p.Gln474His)	single nucleotide variant	not provided [RCV000895294]	Chr6:43178873 [GRCh38] Chr6:43146611 [GRCh37] Chr6:6p21.1	likely benign
NM_003131.4(SRF):c.495G>A (p.Lys165=)	single nucleotide variant	not provided [RCV000913428]	Chr6:43172151 [GRCh38] Chr6:43139889 [GRCh37] Chr6:6p21.1	likely benign
NC_000006.11:g.(?_42928506)_(43737486_?)del	deletion	not provided [RCV001384708]	Chr6:42928506..43737486 [GRCh37] Chr6:6p21.1	pathogenic

miRNA Target Status

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
MIR1-1	hsa-miR-1	Mirtarbase	external_info	Western blot	Non-Functional MTI	20458751
MIR1-1	hsa-miR-1	Tarbase	external_info	Westernblit	NEGATIVE

Predicted Target Of

	Summary Value
Count of predictions:	2010
Count of miRNA genes:	866
Interacting mature miRNAs:	1064
Transcripts:	ENST00000265354, ENST00000457278
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

RH46608

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	43,148,972 - 43,149,160	UniSTS	GRCh37
Build 36	6	43,256,950 - 43,257,138	RGD	NCBI36
Celera	6	44,701,193 - 44,701,381	RGD
Cytogenetic Map	6	p21.1	UniSTS
HuRef	6	42,865,662 - 42,865,850	UniSTS
GeneMap99-GB4 RH Map	6	152.25	UniSTS

D6S2165

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	43,149,028 - 43,149,160	UniSTS	GRCh37
Build 36	6	43,257,006 - 43,257,138	RGD	NCBI36
Celera	6	44,701,249 - 44,701,381	RGD
Cytogenetic Map	6	p21.1	UniSTS
HuRef	6	42,865,718 - 42,865,850	UniSTS
Stanford-G3 RH Map	6	2361.0	UniSTS
NCBI RH Map	6	645.2	UniSTS
GeneMap99-G3 RH Map	6	2493.0	UniSTS

SRF_3467

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	43,146,987 - 43,147,718	UniSTS	GRCh37
Build 36	6	43,254,965 - 43,255,696	RGD	NCBI36
Celera	6	44,699,208 - 44,699,939	RGD
HuRef	6	42,863,677 - 42,864,408	UniSTS

D1S3694

Human Assembly	Chr	Position (strand)	Source
Cytogenetic Map	1	p36	UniSTS
Cytogenetic Map	7	q34	UniSTS
Cytogenetic Map	12	q	UniSTS
Cytogenetic Map	6	p21.1	UniSTS
Cytogenetic Map	11	q12.2	UniSTS
Cytogenetic Map	1	q31	UniSTS
Cytogenetic Map	13	q34	UniSTS
Cytogenetic Map	17	p13.1	UniSTS
Cytogenetic Map	11	q13.1-q13.3	UniSTS
Cytogenetic Map	7	q36.1	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

2429

2748

1609

510

1753

352

4355

2147

3175

386

1444

1606

171

1204

2788

Low

243

117

114

198

113

557

Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001292001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_003131	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047419268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB209128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI085561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK300467	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL133375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL355385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC048211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC052572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CS542447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J03161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KT584859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000265354 ⟹ ENSP00000265354

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	6	43,171,269 - 43,181,506 (+)	Ensembl

RefSeq Acc Id:

NM_001292001 ⟹ NP_001278930

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	43,172,396 - 43,181,506 (+)	NCBI
CHM1_1	6	43,143,016 - 43,152,132 (+)	NCBI
T2T-CHM13v2.0	6	43,001,158 - 43,010,279 (+)	NCBI

Sequence:

show sequence

GCAGAGGTGGGAGTGACCGGCGCCAGAGAGGAAGAGGGCCCTTGCTGAGTGAAGGGGCCTATGA
GCTGTCCACGCTGACAGGGACACAGGTGCTGTTGCTGGTGGCCAGTGAGACAGGCCATGTGTAT
ACCTTTGCCACCCGAAAACTGCAGCCCATGATCACCAGTGAGACCGGCAAGGCACTGATTCAGA
CCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACCCCACAACAGACCAGAGAATGAGTGC
CACTGGCTTTGAAGAGACAGATCTCACCTACCAGGTGTCGGAGTCTGACAGCAGTGGGGAGACC
AAGGACACACTGAAGCCGGCGTTCACAGTCACCAACCTGCCGGGTACAACCTCCACCATCCAAA
CAGCACCTAGCACCTCTACCACCATGCAAGTCAGCAGCGGCCCCTCCTTTCCCATCACCAACTA
CCTGGCACCAGTGTCTGCTAGTGTCAGCCCCAGTGCTGTCAGCAGTGCCAATGGGACTGTGCTG
AAGAGTACAGGCAGCGGCCCTGTCTCCTCTGGGGGCCTTATGCAGCTGCCTACCAGCTTCACCC
TCATGCCTGGTGGGGCAGTGGCCCAGCAGGTCCCAGTGCAGGCCATTCAAGTGCACCAGGCCCC
ACAGCAAGCGTCTCCCTCCCGTGACAGCAGCACAGACCTCACGCAGACCTCCTCCAGCGGGACA
GTGACGCTGCCCGCCACCATCATGACGTCATCCGTGCCCACAACTGTGGGTGGCCACATGATGT
ACCCTAGCCCGCATGCGGTGATGTATGCCCCCACCTCGGGCCTGGGTGATGGCAGCCTCACCGT
GCTGAATGCCTTCTCCCAGGCACCATCCACCATGCAGGTGTCACACAGCCAGGTCCAGGAGCCA
GGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAG
TTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCT
ACAGGTGGTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGA
CAGATGGCCCAAGGGATGGCACCACTTATTTATTGTTGCCTTTTCACGTTTTCTTTACACACAC
GTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCCTCTCA
CTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCTCCCCTTCTTCCCG
CCCCACCTCCCATTTCTGTTGCTGGAGGGGCTGTCCTCCTTCCTGGGACCCCCTCGCCAGCTTG
GCTCGATGTTTGCCATGAGTATTAGCTTACCCAATGGGACCGTGCCCCACCTCCCCACACACAG
GCCTTCTGTGGGGCTGGGCACCGTGTCCTCCTCTGAGGAAGCAGTTGGGGCCCTCTTGCCAGCC
TCCTTGCTGACCCCAGGTCAGCCCTGTGTCTGTCACAGGCTGGGTCAAAAGAGCCCTGGCTCTG
CCCCTCAGGGGGCCAGCTGGGGAGATGGGGGCTTCTTCCTCACACTGCTGTCCTCTCCCCCTTC
AGCTCCTGAGTAGCTGGGCCTGTGCACTGGGCAGGTTCCTGGGGCCGCCTGCCCTGCCTTGCCG
CTCCCCTTGGACCTCCAGGGGCTCCTGGGTTGGAGGGAACCACCAGCGTTCCCTTCTCCCCCTT
GTCTTCCCCCCTCTCCTCCCAGCTGCTTTACTTAAAGTTGATTTTGAACTTTTTATTTGAGGAG
ACGAAGTGAAAACAAATCTATAAATATATATTTTTAAAATATTTAACTTTTTTTTATGGCGTTT
TTCTCGTCCCCCTCCCTGCCCAAACTCCCCTTCCCTGGGGAGCCCTCAGGCTCCCCAGAACTGG
CTGGGCCCCTGGGGACAGAGCCACCCCATGAGCTCGGGGTCCACCAGTGTGTGGGGGAGATTCT
GGGTTTGCCCAGTCCTGGGTTGTTTCCAGGAGAAAGCCGGGGGAGGGGCCCTCAGGCCATTCCC
CAACGGGGTGGGGAGGGTGACCCACAGCTCTGGGCCTCTTTTTGCCCTTTAGGGCTGTTGCTAG
GGAGAGGGAAGAGGGAGACCAAATGTCGGGGTTGGGGTGGGAGGGCGTCAGGCAGAGGCAACTG
ACTTCATTTGTGCCACACGCATGGGCATTGCAGCCTTGCGCTGTCCCAGGCATGCAGCTGCCTG
GGGCCCAAGTTGCAGTGAGCAGGGTGGGGTCTGGGAGGGGGTGAGAGGCAGGAATGGGGGTCAG
AAGAAGTGGGAGCAGCTTCTTGGGCTGAGTGCAGCCAAAGGGGAGCCAGAAATGGGCAGTTCTC
CCAGGGAGTGAGCAGCTACTGTAACTTTTTTAAATTAAGACAAAAAGCCTTGAAGAAAATGACT
TTATTTTTCTAAGTGTAACCTCAGTATTTATGTAATTTGTACAGGGGCCATGCCCCACCCCCCT
CCTCCCCCTTTGGGGTAGACCTTGAGGGTGGGCCAGCATAGGGGGGAGGGTCTTTTACCCTGTG
TCAGAGCCTACCTTCACCACCTATATCCAGAAGGGGAGCTTTTTCAGAAACAGGGCAGCAGTGG
GGTGAAATTTTCTTAACCCCTAAGACTGCCTTCAGTAGGAACAAGCTGGCTTCTGTGATTAGGT
GAAGGGATGGGGGAAGATTTTATGCACAGCCTAGTTATCAAGGGGATGATTTGCCGACATGTTT
GAGAACCCCCTAACCTCTAACCCTCATTGCTGTCTTGCCCCAGTTTGGGGTGCCAAGATGGAAG
TCACCTTTCTGGGCTTTCTCCTGGAGATAGCTGGGGCTTATGGGTGGCTTTCAAGGCTGGGGCA
TGGCAAATCAGGGGCCAGAGAGCAGGGGAGCTTGGGACTCAGGTCTGTAACTGCCCAGCCCCTT
TTCTCTGCTCTTGTTTCACTCCACCATCACTCACTCACTCCCCACTCCCCCACCCATGGGGAGG
AGACCTTTGATGAATTCTTCCTCTCCTTCCCACAAAAGACAGACCCAGTGAGTGAATCAGGCAA
AGTGCTTATAATGTGTGTTGTGTGAGCGTGGCCTTGGGAGGACATGCGTGTGTCAGGGATGAGT
TGAGGTGATATTTTTATGTGCAGCGACCCTTGGTGTTTCCCTTCCTCGGTGGCTCTGGGGTATG
TGTGTGTGGGTGTGTGCGCCTGAGTGAGTGTGTGTGCTTGAATGTGAGTGTGTATGTCAGTGGT
TTCTACTTCCCCTGGGATGCTGACCCAGGAATAGTGGACATGGTCACAGTCCTATGTACAGAGC
TTTCTTTTGTATTAAAAAAAAATACTCTTTCAATAAATGTATCATTTTTGTGCACAGA

hide sequence

RefSeq Acc Id:

NM_003131 ⟹ NP_003122

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	43,171,269 - 43,181,506 (+)	NCBI
GRCh37	6	43,138,920 - 43,149,244 (+)	ENTREZGENE
Build 36	6	43,246,898 - 43,257,222 (+)	NCBI Archive
HuRef	6	42,855,575 - 42,865,934 (+)	ENTREZGENE
CHM1_1	6	43,141,921 - 43,152,132 (+)	NCBI
T2T-CHM13v2.0	6	43,000,031 - 43,010,279 (+)	NCBI

Sequence:

show sequence

AAACATTGTATCTCTTTATATGGGGGGAAGGGTCGGGGGATCCCTCCGCCGCCAGCGCGTGGTC
CCGGCCCCCTCCACCCGCCGTCTCGGCCGCGGCCAGCAGCCCCTGCCCCCCGGGGGACGCTGAC
GGCCGCCCGGCGCGCCGCCCTAGCAGACGGACAGGGGGCGCTGCGCGCGGCCTGGGGCAACCCG
GGCCACAGGGGCAGGAAAGTGAGGGCCCAGGTCGGCCCGGGCGTGCAGGGGCCCCGGGTTCGCA
GCGGCGGCCGCGGCAGCGATAGCGGCACTAGCAGCAGCGGGAGTGCCGGGTTGAGCCGGGAAGC
CGATGGCGGCGGCTGCGGCGGCTCCGATTCCTCGCTGACTGCCCGTCCGCCCTCCTGCATCGAG
CGCCATGTTACCGACCCAAGCTGGGGCCGCGGCGGCTCTGGGCCGGGGCTCGGCCCTGGGGGGC
AGCCTGAACCGGACCCCGACGGGGCGGCCGGGCGGCGGCGGCGGGACACGCGGGGCTAACGGGG
GCCGGGTCCCCGGGAATGGCGCGGGGCTCGGGCCCGGCCGCCTGGAGCGGGAGGCTGCGGCAGC
GGCGGCAACCACCCCGGCGCCCACCGCGGGGGCCCTCTACAGCGGCAGCGAGGGCGACTCGGAG
TCGGGCGAGGAGGAGGAGCTGGGCGCCGAGCGGCGCGGCCTGAAGCGGAGCCTGAGCGAGATGG
AGATCGGTATGGTGGTCGGTGGGCCCGAGGCGTCGGCAGCGGCCACCGGGGGCTACGGGCCGGT
GAGCGGCGCGGTGAGCGGGGCCAAGCCGGGTAAGAAGACCCGGGGCCGCGTGAAGATCAAGATG
GAGTTCATCGACAACAAGCTGCGGCGCTACACGACCTTCAGCAAGAGGAAGACGGGCATCATGA
AGAAGGCCTATGAGCTGTCCACGCTGACAGGGACACAGGTGCTGTTGCTGGTGGCCAGTGAGAC
AGGCCATGTGTATACCTTTGCCACCCGAAAACTGCAGCCCATGATCACCAGTGAGACCGGCAAG
GCACTGATTCAGACCTGCCTCAACTCGCCAGACTCTCCACCCCGTTCAGACCCCACAACAGACC
AGAGAATGAGTGCCACTGGCTTTGAAGAGACAGATCTCACCTACCAGGTGTCGGAGTCTGACAG
CAGTGGGGAGACCAAGGACACACTGAAGCCGGCGTTCACAGTCACCAACCTGCCGGGTACAACC
TCCACCATCCAAACAGCACCTAGCACCTCTACCACCATGCAAGTCAGCAGCGGCCCCTCCTTTC
CCATCACCAACTACCTGGCACCAGTGTCTGCTAGTGTCAGCCCCAGTGCTGTCAGCAGTGCCAA
TGGGACTGTGCTGAAGAGTACAGGCAGCGGCCCTGTCTCCTCTGGGGGCCTTATGCAGCTGCCT
ACCAGCTTCACCCTCATGCCTGGTGGGGCAGTGGCCCAGCAGGTCCCAGTGCAGGCCATTCAAG
TGCACCAGGCCCCACAGCAAGCGTCTCCCTCCCGTGACAGCAGCACAGACCTCACGCAGACCTC
CTCCAGCGGGACAGTGACGCTGCCCGCCACCATCATGACGTCATCCGTGCCCACAACTGTGGGT
GGCCACATGATGTACCCTAGCCCGCATGCGGTGATGTATGCCCCCACCTCGGGCCTGGGTGATG
GCAGCCTCACCGTGCTGAATGCCTTCTCCCAGGCACCATCCACCATGCAGGTGTCACACAGCCA
GGTCCAGGAGCCAGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATC
CCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCA
ACCTCACCGAGCTACAGGTGGTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGC
CCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATTTATTGTTGCCTTTTCACGTTT
TCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGA
CTGAGCCCTCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCT
CCCCTTCTTCCCGCCCCACCTCCCATTTCTGTTGCTGGAGGGGCTGTCCTCCTTCCTGGGACCC
CCTCGCCAGCTTGGCTCGATGTTTGCCATGAGTATTAGCTTACCCAATGGGACCGTGCCCCACC
TCCCCACACACAGGCCTTCTGTGGGGCTGGGCACCGTGTCCTCCTCTGAGGAAGCAGTTGGGGC
CCTCTTGCCAGCCTCCTTGCTGACCCCAGGTCAGCCCTGTGTCTGTCACAGGCTGGGTCAAAAG
AGCCCTGGCTCTGCCCCTCAGGGGGCCAGCTGGGGAGATGGGGGCTTCTTCCTCACACTGCTGT
CCTCTCCCCCTTCAGCTCCTGAGTAGCTGGGCCTGTGCACTGGGCAGGTTCCTGGGGCCGCCTG
CCCTGCCTTGCCGCTCCCCTTGGACCTCCAGGGGCTCCTGGGTTGGAGGGAACCACCAGCGTTC
CCTTCTCCCCCTTGTCTTCCCCCCTCTCCTCCCAGCTGCTTTACTTAAAGTTGATTTTGAACTT
TTTATTTGAGGAGACGAAGTGAAAACAAATCTATAAATATATATTTTTAAAATATTTAACTTTT
TTTTATGGCGTTTTTCTCGTCCCCCTCCCTGCCCAAACTCCCCTTCCCTGGGGAGCCCTCAGGC
TCCCCAGAACTGGCTGGGCCCCTGGGGACAGAGCCACCCCATGAGCTCGGGGTCCACCAGTGTG
TGGGGGAGATTCTGGGTTTGCCCAGTCCTGGGTTGTTTCCAGGAGAAAGCCGGGGGAGGGGCCC
TCAGGCCATTCCCCAACGGGGTGGGGAGGGTGACCCACAGCTCTGGGCCTCTTTTTGCCCTTTA
GGGCTGTTGCTAGGGAGAGGGAAGAGGGAGACCAAATGTCGGGGTTGGGGTGGGAGGGCGTCAG
GCAGAGGCAACTGACTTCATTTGTGCCACACGCATGGGCATTGCAGCCTTGCGCTGTCCCAGGC
ATGCAGCTGCCTGGGGCCCAAGTTGCAGTGAGCAGGGTGGGGTCTGGGAGGGGGTGAGAGGCAG
GAATGGGGGTCAGAAGAAGTGGGAGCAGCTTCTTGGGCTGAGTGCAGCCAAAGGGGAGCCAGAA
ATGGGCAGTTCTCCCAGGGAGTGAGCAGCTACTGTAACTTTTTTAAATTAAGACAAAAAGCCTT
GAAGAAAATGACTTTATTTTTCTAAGTGTAACCTCAGTATTTATGTAATTTGTACAGGGGCCAT
GCCCCACCCCCCTCCTCCCCCTTTGGGGTAGACCTTGAGGGTGGGCCAGCATAGGGGGGAGGGT
CTTTTACCCTGTGTCAGAGCCTACCTTCACCACCTATATCCAGAAGGGGAGCTTTTTCAGAAAC
AGGGCAGCAGTGGGGTGAAATTTTCTTAACCCCTAAGACTGCCTTCAGTAGGAACAAGCTGGCT
TCTGTGATTAGGTGAAGGGATGGGGGAAGATTTTATGCACAGCCTAGTTATCAAGGGGATGATT
TGCCGACATGTTTGAGAACCCCCTAACCTCTAACCCTCATTGCTGTCTTGCCCCAGTTTGGGGT
GCCAAGATGGAAGTCACCTTTCTGGGCTTTCTCCTGGAGATAGCTGGGGCTTATGGGTGGCTTT
CAAGGCTGGGGCATGGCAAATCAGGGGCCAGAGAGCAGGGGAGCTTGGGACTCAGGTCTGTAAC
TGCCCAGCCCCTTTTCTCTGCTCTTGTTTCACTCCACCATCACTCACTCACTCCCCACTCCCCC
ACCCATGGGGAGGAGACCTTTGATGAATTCTTCCTCTCCTTCCCACAAAAGACAGACCCAGTGA
GTGAATCAGGCAAAGTGCTTATAATGTGTGTTGTGTGAGCGTGGCCTTGGGAGGACATGCGTGT
GTCAGGGATGAGTTGAGGTGATATTTTTATGTGCAGCGACCCTTGGTGTTTCCCTTCCTCGGTG
GCTCTGGGGTATGTGTGTGTGGGTGTGTGCGCCTGAGTGAGTGTGTGTGCTTGAATGTGAGTGT
GTATGTCAGTGGTTTCTACTTCCCCTGGGATGCTGACCCAGGAATAGTGGACATGGTCACAGTC
CTATGTACAGAGCTTTCTTTTGTATTAAAAAAAAATACTCTTTCAATAAATGTATCATTTTTGT
GCACAGA

hide sequence

RefSeq Acc Id:

XM_047419268 ⟹ XP_047275224

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	43,172,396 - 43,181,506 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001278930	(Get FASTA)	NCBI Sequence Viewer
	NP_003122	(Get FASTA)	NCBI Sequence Viewer
	XP_047275224	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA36647	(Get FASTA)	NCBI Sequence Viewer
	AAH48211	(Get FASTA)	NCBI Sequence Viewer
	AAH52572	(Get FASTA)	NCBI Sequence Viewer
	BAD92365	(Get FASTA)	NCBI Sequence Viewer
	BAG62186	(Get FASTA)	NCBI Sequence Viewer
	CAM91173	(Get FASTA)	NCBI Sequence Viewer
	EAX04161	(Get FASTA)	NCBI Sequence Viewer
	EAX04162	(Get FASTA)	NCBI Sequence Viewer
	P11831	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_003122 ⟸ NM_003131
- Peptide Label:	isoform 1
- UniProtKB:	Q5T648 (UniProtKB/Swiss-Prot), P11831 (UniProtKB/Swiss-Prot), A0A024RD16 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLPTQAGAAAALGRGSALGGSLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGPGRLEREAAAAA ATTPAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMEIGMVVGGPEASAAATGGYGPVS GAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETG HVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEETDLTYQVSESDSS GETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANG TVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIQVHQAPQQASPSRDSSTDLTQTSS SGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLGDGSLTVLNAFSQAPSTMQVSHSQV QEPGGVPQVFLTASSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDTAHSTKSE hide sequence

RefSeq Acc Id:	NP_001278930 ⟸ NM_001292001
- Peptide Label:	isoform 2
- UniProtKB:	P11831 (UniProtKB/Swiss-Prot), B4DU24 (UniProtKB/TrEMBL)
- Sequence:	show sequence MITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEETDLTYQVSESDSSGETKDTLKPAFT VTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVS SGGLMQLPTSFTLMPGGAVAQQVPVQAIQVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMT SSVPTTVGGHMMYPSPHAVMYAPTSGLGDGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLT ASSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDTAHSTKSE hide sequence

RefSeq Acc Id:

ENSP00000265354 ⟸ ENST00000265354

RefSeq Acc Id:	XP_047275224 ⟸ XM_047419268
- Peptide Label:	isoform X1

Protein Domains

MADS-box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P11831-F1-model_v2	AlphaFold	P11831	1-508	view protein structure

Promoters

RGD ID:

7208117

Promoter ID:

EPDNEW_H9805

Type:

initiation region

Name:

SRF_1

Description:

serum response factor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H9806

Experiment Methods:

Single-end sequencing.; Paired-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	43,171,269 - 43,171,329	EPDNEW

RGD ID:

7208121

Promoter ID:

EPDNEW_H9806

Type:

initiation region

Name:

SRF_2

Description:

serum response factor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H9805

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	43,171,455 - 43,171,515	EPDNEW

RGD ID:

6804818

Promoter ID:

HG_KWN:53621

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, K562, Lymphoblastoid, NB4

Transcripts:

NM_003131

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	6	43,246,671 - 43,247,862 (+)	MPROMDB

RGD ID:

6812976

Promoter ID:

HG_ACW:68498

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Lymphoblastoid

Transcripts:

GLUGLARBY.AAPR07-UNSPLICED, SRF.CAPR07-UNSPLICED

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	6	43,249,021 - 43,249,521 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:11291	AgrOrtholog
COSMIC	SRF	COSMIC
Ensembl Genes	ENSG00000112658	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSP00000265354	ENTREZGENE
	ENSP00000265354.4	UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000265354	ENTREZGENE
	ENST00000265354.6	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.1810.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000112658	GTEx
HGNC ID	HGNC:11291	ENTREZGENE
Human Proteome Map	SRF	Human Proteome Map
InterPro	MADS_SRF-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TF_MADSbox	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TF_MADSbox_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:6722	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	6722	ENTREZGENE
OMIM	600589	OMIM
Pfam	SRF-TF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA36116	PharmGKB
PRINTS	MADSDOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	MADS_BOX_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MADS_BOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	MADS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF55455	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A024RD16	ENTREZGENE, UniProtKB/TrEMBL
	B4DU24	ENTREZGENE, UniProtKB/TrEMBL
	P11831	ENTREZGENE
	Q5T648	ENTREZGENE
	SRF_HUMAN	UniProtKB/Swiss-Prot
UniProt Secondary	Q5T648	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-09-08	SRF	serum response factor	SRF	serum response factor (c-fos serum response element-binding transcription factor)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Send us a Message

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)