Srf (serum response factor) - Rat Genome Database

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Gene: Srf (serum response factor) Mus musculus
Analyze
Symbol: Srf
Name: serum response factor
RGD ID: 1321394
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and nucleic acid binding activity. Involved in actin cytoskeleton organization and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and generation of neurons. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including blastocyst; branchial arch; future forebrain; genitourinary system; and salivary gland. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor); PARTICIPATES IN platelet-derived growth factor signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW049942; AW240594
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,857,764 - 46,869,194 (-)NCBIGRCm39mm39
GRCm39 Ensembl1746,859,255 - 46,867,101 (-)Ensembl
GRCm381746,546,838 - 46,558,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,548,329 - 46,556,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,683,788 - 46,693,111 (-)NCBIGRCm37mm9NCBIm37
MGSCv361746,010,028 - 46,019,351 (-)NCBImm8
Celera1749,982,837 - 49,992,041 (-)NCBICelera
Cytogenetic Map17CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IDA,IMP)
actin filament organization  (IMP)
associative learning  (IMP)
bicellular tight junction assembly  (IMP)
branching involved in blood vessel morphogenesis  (IMP)
bronchus cartilage development  (IMP)
cardiac myofibril assembly  (IMP)
cardiac vascular smooth muscle cell differentiation  (IMP)
cell migration involved in sprouting angiogenesis  (IMP,ISO)
cell-cell adhesion  (IMP)
cell-matrix adhesion  (IMP)
cellular response to glucose stimulus  (ISO)
cellular senescence  (ISO)
contractile actin filament bundle assembly  (IMP)
developmental growth  (IMP)
dorsal aorta morphogenesis  (IMP)
epithelial cell-cell adhesion  (IMP)
epithelial structure maintenance  (IMP)
erythrocyte development  (IMP)
eyelid development in camera-type eye  (IMP)
face development  (IMP)
forebrain development  (IMP)
gastrulation  (IMP)
heart development  (IMP)
heart looping  (IMP)
heart trabecula formation  (IMP)
hematopoietic stem cell differentiation  (IMP)
hippocampus development  (IMP)
in utero embryonic development  (IMP)
leukocyte differentiation  (IMP)
long-term memory  (ISO)
long-term synaptic depression  (IMP)
lung morphogenesis  (IMP)
lung smooth muscle development  (IMP)
megakaryocyte development  (IMP)
mesoderm formation  (IMP)
morphogenesis of an epithelial sheet  (IMP)
muscle cell cellular homeostasis  (IMP)
negative regulation of amyloid-beta clearance  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of pri-miRNA transcription by RNA polymerase II  (IDA)
neuron migration  (IMP)
neuron projection development  (IMP)
platelet activation  (IMP)
platelet formation  (IMP)
positive regulation of axon extension  (IGI,IMP)
positive regulation of cell differentiation  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of filopodium assembly  (IMP)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IDA,ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of transcription by glucose  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,IMP,ISO)
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  (IMP,ISO)
positive regulation of transcription initiation from RNA polymerase II promoter  (ISO)
positive regulation of transcription via serum response element binding  (IDA)
positive regulation of transcription, DNA-templated  (IDA,IMP,ISO)
positive thymic T cell selection  (IMP)
primitive streak formation  (IMP)
regulation of cell adhesion  (IMP)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IDA)
regulation of water loss via skin  (IMP)
response to cytokine  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
sarcomere organization  (IMP)
skin morphogenesis  (IMP)
stress fiber assembly  (IMP)
tangential migration from the subventricular zone to the olfactory bulb  (IMP)
thymus development  (IMP)
thyroid gland development  (IMP)
trachea cartilage development  (IMP)
trophectodermal cell differentiation  (ISO)

Cellular Component
chromatin  (IDA)
cytoplasm  (IDA)
nucleoplasm  (TAS)
nucleus  (IC,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apoptosis  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal fetal atrioventricular canal morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal heart shape  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal intercalated disk morphology  (IAGP)
abnormal interventricular groove morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal mature B cell morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal pericardium morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal Z line morphology  (IAGP)
absent marginal zone B cells  (IAGP)
absent mesoderm  (IAGP)
absent thyroid gland  (IAGP)
athymia  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
congestive heart failure  (IAGP)
cyanosis  (IAGP)
decreased B cell number  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased birth weight  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart ventricle  (IAGP)
disorganized myocardium  (IAGP)
distended pericardium  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
failure of primitive streak formation  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased heart left ventricle size  (IAGP)
internal hemorrhage  (IAGP)
irregular heartbeat  (IAGP)
kyphosis  (IAGP)
lethargy  (IAGP)
mandible hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
no spontaneous movement  (IAGP)
pericardial effusion  (IAGP)
persistent truncus arteriosis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
respiratory failure  (IAGP)
thin interventricular septum  (IAGP)
thin myocardium  (IAGP)
trabecula carnea hypoplasia  (IAGP)
vascular smooth muscle hypotrophy  (IAGP)
ventricular septal defect  (IAGP)
References

Additional References at PubMed
PMID:2062642   PMID:8631897   PMID:8663310   PMID:8889548   PMID:8900044   PMID:9218459   PMID:9799237   PMID:9858769   PMID:10847592   PMID:10993896   PMID:11060034   PMID:11278942  
PMID:11439182   PMID:11514558   PMID:11839767   PMID:11857797   PMID:12039949   PMID:12297046   PMID:12397177   PMID:12477932   PMID:12486129   PMID:12525493   PMID:12606287   PMID:12732141  
PMID:12858529   PMID:14681479   PMID:15001533   PMID:15057274   PMID:15102471   PMID:15169892   PMID:15310743   PMID:15489334   PMID:15576363   PMID:15591049   PMID:15610731   PMID:15623502  
PMID:15647354   PMID:15699019   PMID:15728583   PMID:15749018   PMID:15767668   PMID:15837932   PMID:15857835   PMID:15880109   PMID:15929941   PMID:15951802   PMID:16243315   PMID:16368687  
PMID:16415869   PMID:16427017   PMID:16466398   PMID:16510470   PMID:16537394   PMID:16597624   PMID:16705166   PMID:16824956   PMID:16903857   PMID:16914747   PMID:17030628   PMID:17170024  
PMID:17202422   PMID:17215356   PMID:17332502   PMID:17377068   PMID:17468179   PMID:17576768   PMID:17591768   PMID:17629633   PMID:17684061   PMID:18025109   PMID:18036521   PMID:18054566  
PMID:18054567   PMID:18287559   PMID:18316483   PMID:18334560   PMID:18344281   PMID:18442487   PMID:18458156   PMID:18498732   PMID:18498735   PMID:18501668   PMID:18511849   PMID:18557893  
PMID:18570667   PMID:18586895   PMID:18804439   PMID:18945672   PMID:18952847   PMID:19004760   PMID:19015276   PMID:19079548   PMID:19082443   PMID:19116276   PMID:19198601   PMID:19205030  
PMID:19270689   PMID:19307725   PMID:19329434   PMID:19342595   PMID:19350017   PMID:19357276   PMID:19359245   PMID:19398467   PMID:19578358   PMID:19683494   PMID:19745164   PMID:19782130  
PMID:19783823   PMID:19797053   PMID:19801679   PMID:19953255   PMID:20013655   PMID:20019329   PMID:20047077   PMID:20088824   PMID:20123976   PMID:20139090   PMID:20223941   PMID:20378849  
PMID:20404088   PMID:20412781   PMID:20417598   PMID:20428204   PMID:20436479   PMID:20466732   PMID:20525922   PMID:20534669   PMID:20610412   PMID:20685657   PMID:20694003   PMID:20709909  
PMID:20724380   PMID:20739623   PMID:20842632   PMID:20980616   PMID:21098124   PMID:21135125   PMID:21185285   PMID:21267068   PMID:21289070   PMID:21289071   PMID:21292826   PMID:21302281  
PMID:21303526   PMID:21329726   PMID:21336301   PMID:21379568   PMID:21393865   PMID:21401944   PMID:21479245   PMID:21525490   PMID:21552476   PMID:21573132   PMID:21637294   PMID:21768101  
PMID:21785421   PMID:21799516   PMID:21873635   PMID:22022520   PMID:22046433   PMID:22049076   PMID:22090492   PMID:22106411   PMID:22155005   PMID:22157009   PMID:22192413   PMID:22207710  
PMID:22225874   PMID:22278938   PMID:22356487   PMID:22434656   PMID:22537405   PMID:22563064   PMID:22649236   PMID:22674276   PMID:22711842   PMID:22772757   PMID:22806889   PMID:22927399  
PMID:22988430   PMID:22996691   PMID:23028370   PMID:23151848   PMID:23175628   PMID:23264443   PMID:23374345   PMID:23406902   PMID:23426017   PMID:23436819   PMID:23437181   PMID:23558171  
PMID:23563308   PMID:23644458   PMID:23671695   PMID:23674601   PMID:23704920   PMID:23705899   PMID:23771945   PMID:23818299   PMID:23946491   PMID:24068960   PMID:24106278   PMID:24167585  
PMID:24218621   PMID:24248596   PMID:24510125   PMID:24550211   PMID:24574460   PMID:24623780   PMID:24732378   PMID:24758171   PMID:24797074   PMID:24952961   PMID:25020278   PMID:25082846  
PMID:25266280   PMID:25344251   PMID:25453829   PMID:25516967   PMID:25573994   PMID:25631042   PMID:25636686   PMID:25639799   PMID:25681733   PMID:25703143   PMID:25774500   PMID:25868726  
PMID:26221020   PMID:26408645   PMID:26440278   PMID:26638868   PMID:26670661   PMID:26691724   PMID:26719331   PMID:26844834   PMID:27914009   PMID:27922676   PMID:27930960   PMID:28112683  
PMID:28125644   PMID:28152551   PMID:28260872   PMID:28286024   PMID:28342289   PMID:28555077   PMID:28574994   PMID:28576971   PMID:28607167   PMID:28716058   PMID:29114040   PMID:29187823  
PMID:29217642   PMID:29269426   PMID:29284006   PMID:29367466   PMID:29643333   PMID:30026494   PMID:30242271   PMID:30548190   PMID:30598445   PMID:30771308   PMID:30850733   PMID:31191527  
PMID:31201155   PMID:31364026   PMID:31375980   PMID:31435710   PMID:31442911   PMID:32210317   PMID:32408395   PMID:32450132   PMID:32603734   PMID:33361330   PMID:34184741  


Genomics

Comparative Map Data
Srf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,857,764 - 46,869,194 (-)NCBIGRCm39mm39
GRCm39 Ensembl1746,859,255 - 46,867,101 (-)Ensembl
GRCm381746,546,838 - 46,558,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,548,329 - 46,556,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,683,788 - 46,693,111 (-)NCBIGRCm37mm9NCBIm37
MGSCv361746,010,028 - 46,019,351 (-)NCBImm8
Celera1749,982,837 - 49,992,041 (-)NCBICelera
Cytogenetic Map17CNCBI
SRF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl643,171,269 - 43,181,506 (+)EnsemblGRCh38hg38GRCh38
GRCh38643,171,269 - 43,181,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37643,139,007 - 43,149,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,246,898 - 43,257,222 (+)NCBINCBI36hg18NCBI36
Build 34643,247,014 - 43,257,221NCBI
Celera644,691,142 - 44,701,465 (+)NCBI
Cytogenetic Map6p21.1NCBI
HuRef642,855,575 - 42,865,934 (+)NCBIHuRef
CHM1_1643,141,808 - 43,152,132 (+)NCBICHM1_1
Srf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2914,426,453 - 14,435,734 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl914,426,472 - 14,435,733 (+)Ensembl
Rnor_6.0916,737,637 - 16,747,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,737,642 - 16,747,225 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,642,584 - 15,652,178 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,788,378 - 9,797,639 (+)NCBIRGSC3.4rn4RGSC3.4
Celera912,173,971 - 12,183,234 (+)NCBICelera
Cytogenetic Map9q12NCBI
Srf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,098,968 - 9,107,057 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,100,546 - 9,109,305 (+)NCBIChiLan1.0ChiLan1.0
SRF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1644,057,192 - 44,066,768 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,057,192 - 44,066,768 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0642,763,099 - 42,773,332 (+)NCBIMhudiblu_PPA_v0panPan3
SRF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,664,441 - 11,673,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,664,527 - 11,671,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,691,502 - 11,700,834 (+)NCBI
ROS_Cfam_1.01212,146,868 - 12,156,424 (+)NCBI
UMICH_Zoey_3.11211,674,421 - 11,683,753 (+)NCBI
UNSW_CanFamBas_1.01211,758,840 - 11,768,172 (+)NCBI
UU_Cfam_GSD_1.01211,853,634 - 11,862,966 (+)NCBI
Srf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,170,709 - 47,180,262 (+)NCBI
SpeTri2.0NW_00493647616,779,941 - 16,789,499 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,213,063 - 38,222,140 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,213,300 - 38,223,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,712,387 - 43,724,048 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,983,161 - 28,993,465 (-)NCBI
ChlSab1.1 Ensembl1728,983,002 - 28,992,995 (-)Ensembl
Vero_WHO_p1.0NW_02366604443,231,123 - 43,241,353 (+)NCBI
Srf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475416,371,995 - 16,381,287 (-)NCBI

Position Markers
AW822025  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,548,429 - 46,548,676UniSTSGRCm38
MGSCv371746,685,378 - 46,685,625UniSTSGRCm37
Celera1749,984,427 - 49,984,674UniSTS
Cytogenetic Map17CUniSTS
Whitehead/MRC_RH17564.1UniSTS
AW049942  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,547,242 - 46,547,331UniSTSGRCm38
MGSCv371746,684,191 - 46,684,280UniSTSGRCm37
Celera1749,983,240 - 49,983,329UniSTS
Cytogenetic Map17CUniSTS
Whitehead/MRC_RH17561.8UniSTS
AW240594  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,547,096 - 46,547,180UniSTSGRCm38
MGSCv371746,684,045 - 46,684,129UniSTSGRCm37
Celera1749,983,094 - 49,983,178UniSTS
Cytogenetic Map17CUniSTS
Whitehead/MRC_RH17569.91UniSTS
Srf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,548,918 - 46,549,157UniSTSGRCm38
MGSCv371746,685,867 - 46,686,106UniSTSGRCm37
Celera1749,984,916 - 49,985,155UniSTS
Cytogenetic Map17CUniSTS
cM MapUN UniSTS
cM Map17 UniSTS
PMC305791P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,554,747 - 46,555,395UniSTSGRCm38
MGSCv371746,691,696 - 46,692,344UniSTSGRCm37
Celera1749,990,626 - 49,991,274UniSTS
Cytogenetic Map17CUniSTS
SRF_3467  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,548,301 - 46,549,024UniSTSGRCm38
MGSCv371746,685,250 - 46,685,973UniSTSGRCm37
Celera1749,984,299 - 49,985,022UniSTS
Cytogenetic Map17CUniSTS
Srf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17CUniSTS
Srf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17CUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3076892947728778Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173290000053800000Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173495684169858931Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173565926669659396Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173648271570482715Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173840588672405969Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173849862572498625Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173849862572498625Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4022744774227623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174063218774632187Mouse
4141478Hbnr7_mHeligmosomoides bakeri nematode resistance 7 (mouse)Not determined4274029451432094Mouse
26884386Skwq13_mskull length QTL 13, 16 week (mouse)174340000052800000Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174340000067500000Mouse
12903997Cfq4_mconditioned fear QTL 4 (mouse)174470566549059374Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174620000082100000Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir133a-2mmu-miR-133a-3pMirtarbaseexternal_infoMicroarray//Northern blotFunctional MTI (Weak)16380711

Predicted Target Of
Summary Value
Count of predictions:1178
Count of miRNA genes:517
Interacting mature miRNAs:624
Transcripts:ENSMUST00000015749
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000015749   ⟹   ENSMUSP00000015749
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1746,859,255 - 46,867,101 (-)Ensembl
GRCm38.p6 Ensembl1746,548,329 - 46,556,175 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233104   ⟹   ENSMUSP00000156719
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1746,859,925 - 46,861,945 (-)Ensembl
GRCm38.p6 Ensembl1746,548,999 - 46,551,019 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233767
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1746,859,801 - 46,861,026 (-)Ensembl
GRCm38.p6 Ensembl1746,548,875 - 46,550,100 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233797
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1746,861,615 - 46,862,719 (-)Ensembl
GRCm38.p6 Ensembl1746,550,689 - 46,551,793 (-)Ensembl
RefSeq Acc Id: NM_020493   ⟹   NP_065239
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391746,857,765 - 46,867,088 (-)NCBI
GRCm381746,546,839 - 46,556,162 (-)NCBI
MGSCv371746,683,788 - 46,693,111 (-)RGD
Celera1749,982,837 - 49,992,041 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006523957   ⟹   XP_006524020
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391746,857,764 - 46,869,194 (-)NCBI
GRCm381746,546,838 - 46,558,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246336   ⟹   XP_011244638
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391746,857,764 - 46,865,989 (-)NCBI
GRCm381746,546,838 - 46,555,063 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_065239   ⟸   NM_020493
- UniProtKB: Q9JM73 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006524020   ⟸   XM_006523957
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011244638   ⟸   XM_011246336
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000015749   ⟸   ENSMUST00000015749
RefSeq Acc Id: ENSMUSP00000156719   ⟸   ENSMUST00000233104
Protein Domains
MADS-box

Promoters
RGD ID:13676230
Promoter ID:EPDNEW_M22264
Type:initiation region
Name:Srf_1
Description:Mus musculus serum response factor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381746,556,169 - 46,556,229EPDNEW
RGD ID:6847463
Promoter ID:MM_ACW:22879
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Lung,   MEF_B4
Transcripts:SRF.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361746,691,761 - 46,692,261 (-)MPROMDB
RGD ID:6828717
Promoter ID:MM_KWN:23655
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000015749
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361746,692,906 - 46,693,512 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106658 AgrOrtholog
Ensembl Genes ENSMUSG00000015605 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000015749 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000156719 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000015749 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000233104 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1810.10 UniProtKB/Swiss-Prot
InterPro MADS_SRF-like UniProtKB/Swiss-Prot
  TF_MADSbox UniProtKB/Swiss-Prot
  TF_MADSbox_sf UniProtKB/Swiss-Prot
KEGG Report mmu:20807 UniProtKB/Swiss-Prot
MGD MGI:106658 ENTREZGENE
NCBI Gene 20807 ENTREZGENE
Pfam SRF-TF UniProtKB/Swiss-Prot
PhenoGen Srf PhenoGen
PRINTS MADSDOMAIN UniProtKB/Swiss-Prot
PROSITE MADS_BOX_1 UniProtKB/Swiss-Prot
  MADS_BOX_2 UniProtKB/Swiss-Prot
SMART MADS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55455 UniProtKB/Swiss-Prot
UniProt A0A3B2WCW1_MOUSE UniProtKB/TrEMBL
  Q9JM73 ENTREZGENE, UniProtKB/Swiss-Prot