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Gene: Srf (serum response factor) Mus musculus
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Symbol: Srf
Name: serum response factor
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and nucleic acid binding activity. Involved in several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription by RNA polymerase II. Localizes to the cytoplasm and nuclear chromatin. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Is expressed in several structures, including blastocyst; forebrain; genitourinary system; heart; and salivary gland. Orthologous to human SRF (serum response factor); PARTICIPATES IN platelet-derived growth factor signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW049942; AW240594
Orthologs:
Homo sapiens (human) : SRF (serum response factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Srf (serum response factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srf (serum response factor)
Pan paniscus (bonobo/pygmy chimpanzee) : SRF (serum response factor)
Canis lupus familiaris (dog) : SRF (serum response factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srf (serum response factor)
Sus scrofa (pig) : SRF (serum response factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381746,546,838 - 46,558,267 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371746,683,788 - 46,693,111 (-)NCBIGRCm37mm9NCBIm37
MGSCv361746,010,028 - 46,019,351 (-)NCBImm8
Celera1749,982,837 - 49,992,041 (-)NCBICelera
Cytogenetic Map17 CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Srf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321394
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.