Apoa4 (apolipoprotein A4) - Rat Genome Database

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Gene: Apoa4 (apolipoprotein A4) Heterocephalus glaber
Analyze
Symbol: Apoa4
Name: apolipoprotein A4
RGD ID: 18936068
Description: ENCODES a protein that exhibits antioxidant activity (inferred); cholesterol transfer activity (inferred); copper ion binding (inferred); INVOLVED IN peripheral nervous system axon regeneration (ortholog); regulation of intestinal cholesterol absorption (ortholog); response to triglyceride (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); atherosclerosis (ortholog); FOUND IN chylomicron (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apolipoprotein A-IV
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,233,593 - 12,239,763 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,237,329 - 12,240,013 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alzheimer's disease  (ISO)
anemia  (ISO)
atherosclerosis  (ISO)
cardiovascular system disease  (ISO)
CD3epsilon deficiency  (ISO)
Chemically-Induced Disorders  (ISO)
Chromosome 11, Partial Trisomy 11q  (ISO)
chronic kidney disease  (ISO)
Chronic Pancreatitis  (ISO)
colitis  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
diabetic retinopathy  (ISO)
Dwarfism  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Familial Pancreatic Carcinoma  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
graft-versus-host disease  (ISO)
Guillain-Barre syndrome  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
Hyperlipoproteinemia Type II  (ISO)
Hyperlipoproteinemias  (ISO)
Hypertriglyceridemia  (ISO)
immunodeficiency 17  (ISO)
immunodeficiency 18  (ISO)
immunodeficiency 19  (ISO)
Inflammation  (ISO)
inflammatory bowel disease 28  (ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
Intervertebral Disc Displacement  (ISO)
isolated microphthalmia 5  (ISO)
Leber hereditary optic neuropathy  (ISO)
major depressive disorder  (ISO)
myocardial infarction  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephronophthisis 15  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (ISO)
polyneuropathy  (ISO)
primary hypoalphalipoproteinemia 2  (ISO)
RASopathy  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
retinal detachment  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
Seasonal Allergic Rhinitis  (ISO)
ulcerative colitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Apoa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,233,593 - 12,239,763 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,237,329 - 12,240,013 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
APOA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,820,700 - 116,823,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11116,820,700 - 116,823,304 (-)EnsemblGRCh38hg38GRCh38
GRCh3711116,691,416 - 116,694,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,196,628 - 116,199,221 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411116,196,628 - 116,199,162NCBI
Celera11113,849,234 - 113,851,827 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11112,623,690 - 112,626,283 (-)NCBIHuRef
CHM1_111116,576,178 - 116,578,767 (-)NCBICHM1_1
T2T-CHM13v2.011116,835,812 - 116,838,412 (-)NCBIT2T-CHM13v2.0
Apoa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,152,142 - 46,154,756 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl946,151,994 - 46,154,757 (+)EnsemblGRCm39 Ensembl
GRCm38946,240,844 - 46,243,458 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,240,696 - 46,243,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,048,927 - 46,051,541 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,992,149 - 45,994,285 (+)NCBIMGSCv36mm8
Celera943,529,774 - 43,532,388 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
Apoa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,435,779 - 55,438,160 (+)NCBIGRCr8
mRatBN7.2846,539,083 - 46,541,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,539,082 - 46,541,469 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx852,040,348 - 52,042,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,319,122 - 50,321,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0848,183,398 - 48,185,778 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,536,983 - 50,539,371 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,537,009 - 50,539,376 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,163,055 - 49,165,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4849,233,142 - 49,233,431 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1849,245,005 - 49,245,297 (+)NCBI
Celera846,121,074 - 46,123,455 (+)NCBICelera
RH 3.4 Map8473.3RGD
Cytogenetic Map8q22NCBI
Apoa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,155,801 - 18,160,701 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,158,095 - 18,160,636 (-)NCBIChiLan1.0ChiLan1.0
APOA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,524,912 - 117,527,516 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111118,630,121 - 118,632,725 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011111,659,186 - 111,661,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111115,591,788 - 115,594,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,591,788 - 115,594,382 (-)Ensemblpanpan1.1panPan2
APOA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,751,588 - 16,754,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,751,799 - 16,754,837 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,803,839 - 16,806,395 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,698,167 - 16,700,719 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,698,240 - 16,701,326 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,835,250 - 16,837,800 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,737,834 - 16,740,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,780,743 - 16,783,293 (+)NCBIUU_Cfam_GSD_1.0
Apoa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,177,114 - 99,179,837 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,098,683 - 2,101,127 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,098,683 - 2,101,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,201,508 - 44,204,206 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,201,587 - 44,204,072 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,273,837 - 49,276,322 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,186,627 - 108,190,508 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,186,921 - 108,189,698 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,861,078 - 17,863,578 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000027544   ⟹   ENSHGLP00000027303
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478412,233,593 - 12,239,763 (-)Ensembl
RefSeq Acc Id: XM_004856642   ⟹   XP_004856699
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478412,237,329 - 12,240,013 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004856699 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB11534 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000027303
  ENSHGLP00000053484
  ENSHGLP00100059746
Reference Protein Sequences
RefSeq Acc Id: XP_004856699   ⟸   XM_004856642
- UniProtKB: G5BQH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000027303   ⟸   ENSHGLT00000027544


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019410 Ensembl, ENTREZGENE
  ENSHGLG00000049508 UniProtKB/TrEMBL
  ENSHGLG00100041772 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000027544 ENTREZGENE
  ENSHGLT00000070364 UniProtKB/TrEMBL
  ENSHGLT00100088872 UniProtKB/TrEMBL
Gene3D-CATH Apolipoprotein UniProtKB/TrEMBL
InterPro ApoA_E UniProtKB/TrEMBL
KEGG Report hgl:101724709 UniProtKB/TrEMBL
NCBI Gene Apoa4 ENTREZGENE
PANTHER APOLIPOPROTEIN UniProtKB/TrEMBL
  APOLIPOPROTEIN A-IV UniProtKB/TrEMBL
Pfam Apolipoprotein UniProtKB/TrEMBL
Superfamily-SCOP Apolipoprotein A-I UniProtKB/TrEMBL
UniProt G5BQH3 ENTREZGENE, UniProtKB/TrEMBL