RGD Reference Report - Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. - Rat Genome Database

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Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway.

Authors: Ng, KT  Man, K  Ho, JW  Sun, CK  Lee, TK  Zhao, Y  Lo, CM  Poon, RT  Fan, ST 
Citation: Ng KT, etal., Int J Oncol. 2007 Feb;30(2):375-80.
RGD ID: 2292584
Pubmed: PMID:17203219   (View Abstract at PubMed)

We aim to investigate the anticancer effect of a novel immunomodulator FTY720 on a rat orthotopic liver tumor model. A buffalo rat orthotopic liver tumor model was established by injection of a buffalo hepatoma cell line MH7777 into the right portal vein. FTY720 was administered by intraperitoneal injection starting at 10 days after tumor cell injection at a dosage of 5 mg/kg/day. FTY720 markedly suppressed tumor growth and inhibited tumor progression by selective induction of apoptosis of tumor cells via down-regulation of phospho-Akt(ser473) and up-regulation of cleaved caspase-3, together with decrease of focal adhesion kinase. Moreover, the proliferation index of tumor cells was significantly reduced to 15.92+/-5.03% by FTY720 compared with that of 42.92+/-4.47% in the control group (p<0.001). In addition, we confirmed that FTY720 caused no effect on infiltrated lymphocyte in tumor tissue. We conclude that FTY720 is an effective anticancer agent for liver tumor in a rat model without affecting the immune system of the host.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma  ISOPtk2 (Rattus norvegicus)2292584; 2292584 RGD 
hepatocellular carcinoma  IMP 2292584 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptk2  (protein tyrosine kinase 2)

Genes (Mus musculus)
Ptk2  (PTK2 protein tyrosine kinase 2)

Genes (Homo sapiens)
PTK2  (protein tyrosine kinase 2)


Additional Information