Melk (maternal embryonic leucine zipper kinase) - Rat Genome Database

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Gene: Melk (maternal embryonic leucine zipper kinase) Heterocephalus glaber
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Symbol: Melk
Name: maternal embryonic leucine zipper kinase
RGD ID: 18917621
Description: ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase activity (inferred); AMP-activated protein kinase activity (inferred); ATP binding (inferred); INVOLVED IN intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); protein autophosphorylation (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); distal arthrogryposis type 1A (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ortholog); FOUND IN cell cortex (inferred); cytoplasm (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624930247,018 - 333,240 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Melk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624930247,018 - 333,240 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MELK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38936,572,895 - 36,677,682 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl936,572,862 - 36,677,683 (+)EnsemblGRCh38hg38GRCh38
GRCh37936,572,892 - 36,677,679 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36936,562,905 - 36,667,679 (+)NCBINCBI36Build 36hg18NCBI36
Build 34936,562,904 - 36,667,678NCBI
Celera936,506,192 - 36,610,971 (+)NCBICelera
Cytogenetic Map9p13.2NCBI
HuRef936,525,297 - 36,629,824 (+)NCBIHuRef
CHM1_1936,573,419 - 36,678,272 (+)NCBICHM1_1
T2T-CHM13v2.0936,595,568 - 36,700,421 (+)NCBIT2T-CHM13v2.0
Melk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39444,300,876 - 44,364,301 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl444,300,876 - 44,364,675 (+)EnsemblGRCm39 Ensembl
GRCm38444,300,909 - 44,364,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl444,300,876 - 44,364,675 (+)EnsemblGRCm38mm10GRCm38
MGSCv37444,313,789 - 44,377,547 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36444,322,017 - 44,385,775 (+)NCBIMGSCv36mm8
Celera444,320,472 - 44,384,714 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map423.46NCBI
Melk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8563,336,151 - 63,396,254 (+)NCBIGRCr8
mRatBN7.2558,540,393 - 58,600,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl558,540,449 - 58,600,937 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx560,522,076 - 60,582,306 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0562,340,875 - 62,401,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0562,310,545 - 62,371,306 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,783,835 - 59,844,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,783,890 - 59,844,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0564,307,418 - 64,367,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,787,123 - 60,848,620 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,787,312 - 60,848,021 (+)NCBI
Celera557,118,072 - 57,178,790 (+)NCBICelera
Cytogenetic Map5q22NCBI
Melk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541929,717,978 - 29,815,170 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541929,718,291 - 29,815,163 (-)NCBIChiLan1.0ChiLan1.0
MELK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21187,915,014 - 88,018,519 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1987,920,955 - 88,024,441 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0936,419,974 - 36,522,584 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1937,219,170 - 37,321,318 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl937,219,170 - 37,321,318 (+)Ensemblpanpan1.1panPan2
MELK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,970,699 - 53,067,169 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,977,260 - 53,067,172 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1151,561,713 - 51,658,190 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01154,080,440 - 54,176,384 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1154,080,479 - 54,176,384 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11152,581,152 - 52,676,189 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01152,608,391 - 52,704,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01153,304,276 - 53,400,894 (+)NCBIUU_Cfam_GSD_1.0
Melk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,914,905 - 167,997,045 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365244,469,256 - 4,544,290 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365244,479,639 - 4,544,561 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MELK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1237,317,191 - 237,431,589 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11237,317,161 - 237,431,522 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21265,174,996 - 265,288,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MELK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11243,901,840 - 44,007,855 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1243,901,551 - 44,007,266 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603840,975,306 - 41,080,086 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_021251989   ⟹   XP_021107648
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624930247,018 - 333,240 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021107648 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001632
  ENSHGLP00000050813
  ENSHGLP00100057865
GenBank Protein JAO01107 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021107648   ⟸   XM_021251989
- UniProtKB: A0A0P6JI40 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001242 ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100011577 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000001676 ENTREZGENE
  ENSHGLT00000082459 UniProtKB/TrEMBL
  ENSHGLT00100048828 UniProtKB/TrEMBL
Gene3D-CATH Kinase associated domain 1, KA1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro KA1/Ssp2_C UniProtKB/TrEMBL
  KA1_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MELK UniProtKB/TrEMBL
  MELK_UBA UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Melk ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE UniProtKB/TrEMBL
Pfam KA1 UniProtKB/TrEMBL
  MELK_UBA UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE KA1 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6JI40 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SGK0_HETGA UniProtKB/TrEMBL