Tbx3 (T-box transcription factor 3) - Rat Genome Database

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Gene: Tbx3 (T-box transcription factor 3) Heterocephalus glaber
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Symbol: Tbx3
Name: T-box transcription factor 3
RGD ID: 18905986
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior axis specification, embryo (ortholog); atrioventricular bundle cell differentiation (ortholog); ASSOCIATED WITH aortic valve disease 2 (ortholog); Breast Neoplasms (ortholog); colorectal cancer (ortholog); FOUND IN cilium (ortholog); transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T-box 3; T-box transcription factor TBX3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474718,128,028 - 18,142,451 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474718,128,003 - 18,142,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
anterior/posterior axis specification, embryo  (ISO)
atrioventricular bundle cell differentiation  (ISO)
atrioventricular canal development  (ISO)
atrioventricular canal morphogenesis  (ISO)
blood vessel development  (ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac jelly development  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle cell fate commitment  (ISO)
cell fate specification  (IEA)
cellular senescence  (ISO)
DNA-templated transcription  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic heart tube development  (ISO)
embryonic hindlimb morphogenesis  (ISO)
endocardial cushion formation  (ISO)
female genitalia development  (ISO)
follicle-stimulating hormone secretion  (ISO)
forelimb morphogenesis  (ISO)
heart looping  (ISO)
heart morphogenesis  (ISO)
hepatoblast differentiation  (ISO)
in utero embryonic development  (ISO)
inner ear morphogenesis  (ISO)
limb morphogenesis  (ISO)
limbic system development  (ISO)
luteinizing hormone secretion  (ISO)
male genitalia development  (ISO)
mammary gland development  (ISO)
mammary placode formation  (ISO)
mesoderm morphogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell proliferation involved in heart morphogenesis  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell differentiation  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of stem cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
outflow tract morphogenesis  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (ISO)
regulation of protein complex stability  (ISO)
regulation of protein stability  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
roof of mouth development  (ISO)
semicircular canal morphogenesis  (ISO)
sinoatrial node cell development  (ISO)
skeletal system development  (ISO)
smooth muscle cell differentiation  (ISO)
specification of animal organ position  (ISO)
stem cell population maintenance  (ISO)
stem cell proliferation  (ISO)
ureteric peristalsis  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tbx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474718,128,028 - 18,142,451 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474718,128,003 - 18,142,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TBX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812114,670,255 - 114,684,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12114,670,255 - 114,684,175 (-)EnsemblGRCh38hg38GRCh38
GRCh3712115,108,060 - 115,121,980 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612113,592,442 - 113,606,352 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412113,570,778 - 113,584,689NCBI
Celera12114,735,560 - 114,749,458 (-)NCBICelera
Cytogenetic Map12q24.21NCBI
HuRef12112,116,904 - 112,130,825 (-)NCBIHuRef
CHM1_112115,075,996 - 115,089,899 (-)NCBICHM1_1
T2T-CHM13v2.012114,647,343 - 114,661,251 (-)NCBIT2T-CHM13v2.0
Tbx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395119,808,600 - 119,822,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5119,808,734 - 119,822,789 (+)EnsemblGRCm39 Ensembl
GRCm385119,670,534 - 119,684,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5119,670,669 - 119,684,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv375120,120,678 - 120,134,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365119,931,286 - 119,945,218 (+)NCBIMGSCv36mm8
Celera5116,764,719 - 116,778,686 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.34NCBI
Tbx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81242,540,378 - 42,555,490 (-)NCBIGRCr8
mRatBN7.21236,879,924 - 36,894,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,881,445 - 36,893,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1238,058,977 - 38,070,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01238,672,813 - 38,684,003 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01237,725,254 - 37,736,439 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01242,479,518 - 42,494,588 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,480,560 - 42,492,526 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01244,326,928 - 44,342,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,155,494 - 38,166,670 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11238,018,881 - 38,030,058 (-)NCBI
Celera1238,555,497 - 38,566,664 (-)NCBICelera
Cytogenetic Map12q16NCBI
Tbx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545515,988,663 - 16,000,063 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545515,988,153 - 16,000,156 (+)NCBIChiLan1.0ChiLan1.0
TBX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210122,724,799 - 122,741,407 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112122,721,192 - 122,735,426 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012112,240,050 - 112,254,299 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112115,618,420 - 115,632,327 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12115,620,002 - 115,631,316 (-)Ensemblpanpan1.1panPan2
TBX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12611,694,885 - 11,709,594 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2611,696,565 - 11,708,918 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2611,753,296 - 11,767,965 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02611,953,157 - 11,967,841 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2611,954,731 - 11,966,470 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12611,914,521 - 11,929,199 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02611,977,110 - 11,991,787 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02612,026,728 - 12,041,404 (-)NCBIUU_Cfam_GSD_1.0
Tbx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118152,235,738 - 152,248,370 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365587,230,668 - 7,244,361 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365587,230,361 - 7,243,651 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1437,582,822 - 37,596,766 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11437,582,704 - 37,596,767 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21440,012,569 - 40,026,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TBX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111109,952,100 - 109,966,328 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11109,952,054 - 109,965,065 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037135,142,552 - 135,156,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000026529   ⟹   ENSHGLP00000026294
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474718,128,028 - 18,142,451 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000026530   ⟹   ENSHGLP00000026295
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474718,129,284 - 18,142,451 (+)Ensembl
RefSeq Acc Id: XM_004843723   ⟹   XP_004843780
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474718,128,008 - 18,142,366 (+)NCBI
RefSeq Acc Id: XM_021257394   ⟹   XP_021113053
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474718,128,003 - 18,142,366 (+)NCBI
RefSeq Acc Id: XM_021257395   ⟹   XP_021113054
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474718,128,799 - 18,142,366 (+)NCBI
RefSeq Acc Id: XM_021257396   ⟹   XP_021113055
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474718,128,003 - 18,142,366 (+)NCBI
RefSeq Acc Id: XM_021257397   ⟹   XP_021113056
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474718,128,803 - 18,142,366 (+)NCBI
RefSeq Acc Id: XP_021113053   ⟸   XM_021257394
- Peptide Label: isoform X1
- UniProtKB: A0AAX6SX46 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021113055   ⟸   XM_021257396
- Peptide Label: isoform X1
- UniProtKB: A0AAX6SX46 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004843780   ⟸   XM_004843723
- Peptide Label: isoform X1
- UniProtKB: A0AAX6SX46 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021113054   ⟸   XM_021257395
- Peptide Label: isoform X1
- UniProtKB: A0AAX6SX46 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021113056   ⟸   XM_021257397
- Peptide Label: isoform X2
- UniProtKB: A0AAX6STK8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000026294   ⟸   ENSHGLT00000026529
Ensembl Acc Id: ENSHGLP00000026295   ⟸   ENSHGLT00000026530


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018712 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026529 ENTREZGENE
  ENSHGLT00000026530 ENTREZGENE
Gene3D-CATH Transcription factor, T-box UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd_sf UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/TrEMBL
  T-box_sf UniProtKB/TrEMBL
  TBX2/3_TAD UniProtKB/TrEMBL
  TBX2_3_RD UniProtKB/TrEMBL
  TF_Brachyury UniProtKB/TrEMBL
  TF_T-box UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/TrEMBL
NCBI Gene Tbx3 ENTREZGENE
PANTHER T-BOX PROTEIN-RELATED UniProtKB/TrEMBL
  T-BOX TRANSCRIPTION FACTOR TBX3 UniProtKB/TrEMBL
Pfam T-box UniProtKB/TrEMBL
  TBX2-3_RD UniProtKB/TrEMBL
  TBX2-3_TAD UniProtKB/TrEMBL
PRINTS BRACHYURY UniProtKB/TrEMBL
  TBOX UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/TrEMBL
  TBOX_2 UniProtKB/TrEMBL
  TBOX_3 UniProtKB/TrEMBL
SMART TBOX UniProtKB/TrEMBL
Superfamily-SCOP p53-like transcription factors UniProtKB/TrEMBL
UniProt A0AAX6STK8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SX46 ENTREZGENE, UniProtKB/TrEMBL