RGD Reference Report - Expression of TBX3 in Hepatocellular Carcinoma and Its Clinical Implication. - Rat Genome Database

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Expression of TBX3 in Hepatocellular Carcinoma and Its Clinical Implication.

Authors: Li, Zhian  Wang, Yaxi  Duan, Shasha  Shi, Yilu  Li, Shuling  Zhang, Xiaoshan  Ren, Jianjun 
Citation: Li Z, etal., Med Sci Monit. 2018 Dec 22;24:9324-9333. doi: 10.12659/MSM.909378.
RGD ID: 151361122
Pubmed: PMID:30578408   (View Abstract at PubMed)
PMCID: PMC6320639   (View Article at PubMed Central)
DOI: DOI:10.12659/MSM.909378   (Journal Full-text)

BACKGROUND Hepatocellular carcinoma (HCC) is the fifth most common malignancy in China, and China's annual number of new cases accounts for about 45% of the world total. This research was aimed to study the expression of TBX3 protein in HCC and exploring its clinical significance. MATERIAL AND METHODS We collected tumor tissues and adjacent non-tumoral tissues of 174 patients with HCC undergoing surgical resection. The expression of TBX3 protein in different tissues and cell lines in vitro (LO2, HHL-5, MHC97-L, MHC97-H) was detected by immunohistochemistry or Western blotting, and the relationship between TBX3 expression and clinical data of patients with HCC was analyzed. RESULTS The expression of TBX3 protein in HCC was significantly correlated with histological grade, tumor size, cancer cell metastasis, hepatitis B surface antigen, and the expression of Ki-67 in tumor tissues (P<0.05), and it was positively correlated with serum AFP level (r=0.766, P<0.05). The expression of TBX3 increased with increased histological grade in HCC (P<0.05). Cox regression analysis showed that the expression of TBX3 protein in HCC was an independent risk factor for prognosis (OR=0.524, 95% CI=0.283-0.964). The 5-year survival rate of patients with HCC that highly expressed TBX3 protein was 20.83%, which was significantly lower than the 40.20% rate in patients with low expression (P<0.05). CONCLUSIONS The expression of TBX3 in HCC patients undergoing surgical resection is high, and its expression increases with the degree of tumor differentiation. It is related to the metastasis of tumor cells and is positively correlated with the serum level of AFP and may affect the survival time of HCC patients undergoing surgical resection.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma disease_progressionIEP 151361122protein:increased expression:liver (human)RGD 
hepatocellular carcinoma disease_progressionISOTBX3 (Homo sapiens)151361122; 151361122protein:increased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tbx3  (T-box transcription factor 3)

Genes (Mus musculus)
Tbx3  (T-box 3)

Genes (Homo sapiens)
TBX3  (T-box transcription factor 3)


Additional Information