Rgn (regucalcin) - Rat Genome Database

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Gene: Rgn (regucalcin) Heterocephalus glaber
Analyze
Symbol: Rgn
Name: regucalcin
RGD ID: 18903890
Description: ENCODES a protein that exhibits gluconolactonase activity (ortholog); INVOLVED IN intracellular calcium ion homeostasis (ortholog); kidney development (ortholog); liver development (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: regucalcin (senescence marker protein-30)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,883,213 - 3,899,277 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,881,624 - 3,900,144 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
intracellular calcium ion homeostasis  (ISO)
kidney development  (ISO)
L-ascorbic acid biosynthetic process  (IEA)
liver development  (ISO)
liver regeneration  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of bone development  (ISO)
negative regulation of calcium-dependent ATPase activity  (ISO)
negative regulation of cyclic-nucleotide phosphodiesterase activity  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of DNA catabolic process  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of flagellated sperm motility  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of leucine-tRNA ligase activity  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of phosphoprotein phosphatase activity  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of RNA biosynthetic process  (ISO)
positive regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
positive regulation of dUTP diphosphatase activity  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of phosphatase activity  (ISO)
positive regulation of proteolysis involved in protein catabolic process  (ISO)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
regulation of calcium-mediated signaling  (ISO)
spermatogenesis  (ISO)

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:26763976   PMID:30032202  


Genomics

Comparative Map Data
Rgn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,883,213 - 3,899,277 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,881,624 - 3,900,144 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,078,443 - 47,093,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,078,355 - 47,093,314 (+)EnsemblGRCh38hg38GRCh38
GRCh37X46,937,842 - 46,952,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,822,719 - 46,837,656 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X46,696,510 - 46,708,966NCBI
CeleraX51,129,720 - 51,148,035 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,651,176 - 44,667,384 (+)NCBIHuRef
CHM1_1X46,969,564 - 46,984,507 (+)NCBICHM1_1
T2T-CHM13v2.0X46,485,437 - 46,503,065 (+)NCBIT2T-CHM13v2.0
Rgn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,413,980 - 20,428,328 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,416,026 - 20,428,328 (+)EnsemblGRCm39 Ensembl
GRCm38X20,549,766 - 20,562,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,549,787 - 20,562,089 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,126,944 - 20,139,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,706,777 - 19,719,046 (+)NCBIMGSCv36mm8
CeleraX18,681,357 - 18,693,626 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.04NCBI
Rgn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,172,537 - 4,190,112 (-)NCBIGRCr8
mRatBN7.2X1,619,030 - 1,634,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,619,032 - 1,634,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,653,062 - 1,668,461 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,128,761 - 5,144,164 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,444,046 - 1,459,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,833,484 - 1,848,904 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,833,492 - 1,848,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,626,525 - 2,641,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X13,037,171 - 13,052,846NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX2,182,952 - 2,198,371 (-)NCBICelera
Cytogenetic MapXq11NCBI
Rgn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516955,680 - 978,910 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516958,416 - 978,829 (-)NCBIChiLan1.0ChiLan1.0
RGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X48,703,675 - 48,720,753 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X48,707,048 - 48,724,130 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,513,135 - 39,530,188 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,371,225 - 47,388,881 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,371,226 - 47,388,881 (+)Ensemblpanpan1.1panPan2
RGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,697,292 - 40,715,491 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,698,768 - 40,715,490 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,074,578 - 15,090,960 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,818,343 - 40,849,916 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,833,166 - 40,849,918 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,806,174 - 40,837,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,793,810 - 40,825,378 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,886,864 - 40,918,439 (+)NCBIUU_Cfam_GSD_1.0
Rgn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,032,122 - 33,050,817 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,872,824 - 12,891,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650212,872,938 - 12,891,270 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,726,526 - 41,749,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,725,660 - 41,749,736 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,902,494 - 46,926,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,282,825 - 44,299,027 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,285,601 - 44,299,258 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660769,539,184 - 9,555,388 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000000852   ⟹   ENSHGLP00000000812
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248873,883,213 - 3,899,173 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000000853   ⟹   ENSHGLP00000000813
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248873,883,597 - 3,899,277 (+)Ensembl
RefSeq Acc Id: NM_001310248   ⟹   NP_001297177
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248873,883,800 - 3,899,695 (+)NCBI
RefSeq Acc Id: XM_004871561   ⟹   XP_004871618
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248873,881,631 - 3,900,144 (+)NCBI
RefSeq Acc Id: XM_004871562   ⟹   XP_004871619
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248873,881,624 - 3,900,144 (+)NCBI
RefSeq Acc Id: XM_004871563   ⟹   XP_004871620
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248873,883,790 - 3,900,144 (+)NCBI
RefSeq Acc Id: XM_021249579   ⟹   XP_021105238
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248873,883,688 - 3,900,144 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004871619   ⟸   XM_004871562
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004871618   ⟸   XM_004871561
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021105238   ⟸   XM_021249579
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004871620   ⟸   XM_004871563
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001297177   ⟸   NM_001310248
- UniProtKB: G5AZF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000000813   ⟸   ENSHGLT00000000853
RefSeq Acc Id: ENSHGLP00000000812   ⟸   ENSHGLT00000000852


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000674 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000000852 ENTREZGENE
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  Regucalcin UniProtKB/TrEMBL
  SGL UniProtKB/TrEMBL
  SMP-30 UniProtKB/TrEMBL
KEGG Report hgl:101714522 UniProtKB/TrEMBL
NCBI Gene Rgn ENTREZGENE
PANTHER REGUCALCIN UniProtKB/TrEMBL
  REGUCALCIN UniProtKB/TrEMBL
Pfam SGL UniProtKB/TrEMBL
PRINTS REGUCALCIN UniProtKB/TrEMBL
  SMP30FAMILY UniProtKB/TrEMBL
Superfamily-SCOP Calcium-dependent phosphotriesterase UniProtKB/TrEMBL
UniProt G5AZF6 ENTREZGENE, UniProtKB/TrEMBL