RGD Reference Report - A comparison of succinyladenylate lyase activity and serum sialic acid as markers of malignancy. - Rat Genome Database

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A comparison of succinyladenylate lyase activity and serum sialic acid as markers of malignancy.

Authors: Mack, DO  Lewis, EM  Butler, EM  Archer, WH  Smith, LD 
Citation: Mack DO, etal., Biochem Med. 1985 Dec;34(3):327-34.
RGD ID: 1598766
Pubmed: PMID:2937404   (View Abstract at PubMed)

A comparison was made of succinyladenylate lyase (SAMP lyase), total serum sialic (TSA), and lipid soluble serum sialic acid (LSA) as early markers of malignancy in three experimentally induced rat tumor models. Elevation of SAMP lyase in 3'-methyl-dimethylaminoazobenzene-induced hepatic tumors at 2 weeks corresponded with microscopic detection of preneoplastic lesions with elevation of LSA occurring 2 weeks later. Elevation of breast SAMP lyase concurred with macroscopic presence of dimethylbenzanthracene involved breast tumors with elevation of LSA occurring 12 weeks later. Neither colon SAMP lyase nor LSA increased in rats bearing colon tumors induced by dimethylhydrazine. The determination of TSA was not a reliable indicator of tumor presence for the three types of tumors investigated. Both SAMP lyase and LSA are very good early indicators of hepatic tumor with SAMP lyase an earlier indicator of breast tumor than LSA.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADSLHumanbreast cancer  ISOAdsl (Rattus norvegicus)protein:increased activity:tumor (rat)RGD 
AdslRatbreast cancer  IEP protein:increased activity:tumor (rat)RGD 
AdslMousebreast cancer  ISOAdsl (Rattus norvegicus)protein:increased activity:tumor (rat)RGD 
ADSLHumanExperimental Liver Neoplasms  ISOAdsl (Rattus norvegicus)protein:increased activity:liver (rat)RGD 
AdslRatExperimental Liver Neoplasms  IEP protein:increased activity:liver (rat)RGD 
AdslMouseExperimental Liver Neoplasms  ISOAdsl (Rattus norvegicus)protein:increased activity:liver (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adsl  (adenylosuccinate lyase)

Genes (Mus musculus)
Adsl  (adenylosuccinate lyase)

Genes (Homo sapiens)
ADSL  (adenylosuccinate lyase)


Additional Information