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Gene: ADSL (adenylosuccinate lyase) Homo sapiens
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Symbol: ADSL
Name: adenylosuccinate lyase
Description: Exhibits N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Involved in AMP biosynthetic process and protein tetramerization. Localizes to the cytosol. Implicated in adenylosuccinase lyase deficiency. Biomarker of breast cancer and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adenylosuccinase; AMPS; ASASE; ASL
Orthologs:
Mus musculus (house mouse) : Adsl (adenylosuccinate lyase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Adsl (adenylosuccinate lyase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adsl (adenylosuccinate lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : ADSL (adenylosuccinate lyase)
Canis lupus familiaris (dog) : ADSL (adenylosuccinate lyase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adsl (adenylosuccinate lyase)
Sus scrofa (pig) : ADSL (adenylosuccinate lyase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,346,500 - 40,387,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372240,742,504 - 40,762,577 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,072,509 - 39,092,698 (+)NCBINCBI36hg18NCBI36
Build 342239,067,062 - 39,087,251NCBI
Celera2224,544,565 - 24,564,639 (+)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2223,705,707 - 23,725,685 (+)NCBIHuRef
CHM1_12240,701,395 - 40,721,644 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ADSL
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316916
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.