Flna (filamin A) - Rat Genome Database

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Gene: Flna (filamin A) Heterocephalus glaber
Analyze
Symbol: Flna
Name: filamin A
RGD ID: 18904352
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); Fc-gamma receptor I complex binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN actin crosslink formation (ortholog); actin cytoskeleton organization (ortholog); adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; integrin mediated signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); Aneurysm (ortholog); aortic aneurysm (ortholog); FOUND IN actin cytoskeleton (ortholog); actin filament (ortholog); actin filament bundle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Filamin-A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946812,287 - 837,273 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946812,278 - 836,307 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
Aneurysm  (ISO)
aortic aneurysm  (ISO)
Arterial Thrombosis  (ISO)
arterial tortuosity syndrome  (ISO)
autistic disorder  (ISO)
autosomal hemophilia A  (ISO)
Barth syndrome  (ISO)
Breast Neoplasms  (ISO)
cerebral creatine deficiency syndrome 1  (ISO)
cleft palate  (ISO)
colitis  (ISO)
congenital heart disease  (ISO)
connective tissue disease  (ISO)
craniosynostosis  (ISO)
Developmental Disabilities  (ISO)
disorder of sexual development  (ISO)
Dwarfism  (ISO)
dyskeratosis congenita  (ISO)
Ehlers-Danlos syndrome  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
epilepsy  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor VIII deficiency  (ISO)
Familial Sudden Death  (ISO)
Familial Thoracic Aortic Aneurysm 2  (ISO)
favism  (ISO)
FG syndrome  (ISO)
FG Syndrome 2  (ISO)
frontometaphyseal dysplasia  (ISO)
frontometaphyseal dysplasia 1  (ISO)
Gastrointestinal Hemorrhage  (ISO)
genetic disease  (ISO)
hemorrhagic disease  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hydronephrosis  (ISO)
immunodeficiency 33  (ISO)
intellectual disability  (ISO)
Juberg Hayward Syndrome  (ISO)
Marfan syndrome  (ISO)
Melnick-Needles syndrome  (ISO)
methylmalonic acidemia and homocysteinemia cblX type  (ISO)
microcephaly  (ISO)
mitral valve prolapse  (ISO)
Muscle Hypotonia  (ISO)
myopia  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
Neurodevelopmental Disorders  (ISO)
Nijmegen breakage syndrome  (ISO)
omphalocele  (ISO)
orofacial cleft  (ISO)
osteochondrodysplasia  (ISO)
otopalatodigital syndrome spectrum disorder  (ISO)
otopalatodigital syndrome type 1  (ISO)
otopalatodigital syndrome type 2  (ISO)
paraplegia  (ISO)
patent foramen ovale  (ISO)
periventricular nodular heterotopia  (ISO)
Periventricular Nodular Heterotopia 4  (ISO)
Phyllodes Tumor  (ISO)
prune belly syndrome  (ISO)
scoliosis  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Splenomegaly  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
terminal osseous dysplasia  (ISO)
thoracic aortic aneurysm  (ISO)
thrombocytopenia  (ISO)
tuberous sclerosis  (ISO)
ventricular septal defect  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked cardiac valvular dysplasia  (ISO)
X-linked chronic idiopathic intestinal pseudo-obstruction  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin crosslink formation  (ISO)
actin cytoskeleton organization  (IEA,ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (ISO)
angiogenesis  (ISO)
blood vessel remodeling  (ISO)
cell-cell junction organization  (ISO)
cerebral cortex development  (ISO)
cilium assembly  (ISO)
cytoplasmic sequestering of protein  (ISO)
early endosome to late endosome transport  (ISO)
epithelial to mesenchymal transition  (ISO)
establishment of protein localization  (ISO)
establishment of Sertoli cell barrier  (ISO)
formation of radial glial scaffolds  (ISO)
heart morphogenesis  (ISO)
mitotic spindle assembly  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase I  (ISO)
platelet aggregation  (ISO)
positive regulation of actin filament bundle assembly  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of integrin-mediated signaling pathway  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neuron migration  (ISO)
positive regulation of potassium ion transmembrane transport  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
protein localization to bicellular tight junction  (ISO)
protein localization to cell surface  (ISO)
protein localization to plasma membrane  (ISO)
protein stabilization  (ISO)
receptor clustering  (ISO)
regulation of actin filament bundle assembly  (ISO)
regulation of cell migration  (ISO)
regulation of membrane repolarization during cardiac muscle cell action potential  (ISO)
semaphorin-plexin signaling pathway  (ISO)
synapse organization  (ISO)
tubulin deacetylation  (ISO)
wound healing, spreading of cells  (ISO)

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Flna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946812,287 - 837,273 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946812,278 - 836,307 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
FLNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,348,531 - 154,374,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,348,524 - 154,374,634 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,576,899 - 153,603,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,230,091 - 153,252,845 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X153,097,811 - 153,123,776NCBI
CeleraX153,737,962 - 153,764,068 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,154,186 - 142,180,218 (-)NCBIHuRef
CHM1_1X153,488,516 - 153,514,622 (-)NCBICHM1_1
T2T-CHM13v2.0X152,585,064 - 152,611,166 (-)NCBIT2T-CHM13v2.0
Flna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,267,067 - 73,293,787 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,267,067 - 73,293,426 (-)EnsemblGRCm39 Ensembl
GRCm38X74,223,461 - 74,249,854 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,223,461 - 74,249,820 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,468,800 - 71,491,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X71,468,800 - 71,491,873 (-)NCBIMGSCv36mm8
CeleraX65,477,570 - 65,500,684 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.89NCBI
Flna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X157,159,051 - 157,185,559 (-)NCBIGRCr8
mRatBN7.2X152,007,758 - 152,034,266 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX152,007,758 - 152,031,052 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX154,148,888 - 154,172,182 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,712,123 - 157,735,417 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,383,921 - 155,407,213 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,460,785 - 156,487,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,463,953 - 156,487,245 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,200,936 - 152,227,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,362,334 - 160,385,626 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1135,865,679 - 135,888,971 (+)NCBICelera
Cytogenetic MapXq37NCBI
Flna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580874,233 - 895,232 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580874,233 - 895,172 (+)NCBIChiLan1.0ChiLan1.0
FLNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X154,331,705 - 154,357,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X154,335,307 - 154,361,504 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,799,088 - 143,825,282 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FLNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,058,303 - 122,083,467 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,061,455 - 122,083,203 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,387,038 - 107,412,214 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X125,200,002 - 125,225,183 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX125,199,994 - 125,369,947 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,969,062 - 120,994,237 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,484,172 - 123,509,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,246,013 - 123,271,198 (+)NCBIUU_Cfam_GSD_1.0
Flna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,359,521 - 119,385,421 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368091,097,294 - 1,123,201 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368091,097,288 - 1,123,206 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,890,162 - 124,914,992 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,889,934 - 124,915,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FLNA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,657,580 - 128,683,812 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,657,393 - 128,680,531 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,586,882 - 66,613,103 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000002403   ⟹   ENSHGLP00000002354
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624946812,287 - 837,273 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000002404   ⟹   ENSHGLP00000002355
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624946812,287 - 837,273 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000002405   ⟹   ENSHGLP00000002356
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624946815,413 - 836,040 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000002406   ⟹   ENSHGLP00000002357
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624946815,485 - 836,040 (+)Ensembl
RefSeq Acc Id: XM_004874990   ⟹   XP_004875047
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946812,278 - 836,040 (+)NCBI
RefSeq Acc Id: XM_021252345   ⟹   XP_021108004
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946815,413 - 836,307 (+)NCBI
RefSeq Acc Id: XM_021252346   ⟹   XP_021108005
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946815,413 - 836,040 (+)NCBI
RefSeq Acc Id: XM_021252347   ⟹   XP_021108006
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946812,278 - 836,307 (+)NCBI
RefSeq Acc Id: XM_021252348   ⟹   XP_021108007
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946820,673 - 836,307 (+)NCBI
RefSeq Acc Id: XP_021108006   ⟸   XM_021252347
- Peptide Label: isoform X3
- UniProtKB: A0A0P6J4A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004875047   ⟸   XM_004874990
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J4A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108004   ⟸   XM_021252345
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J4A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108005   ⟸   XM_021252346
- Peptide Label: isoform X2
- UniProtKB: A0A0P6J4A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108007   ⟸   XM_021252348
- Peptide Label: isoform X4
- UniProtKB: G5AVD8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000002354   ⟸   ENSHGLT00000002403
Ensembl Acc Id: ENSHGLP00000002355   ⟸   ENSHGLT00000002404
Ensembl Acc Id: ENSHGLP00000002357   ⟸   ENSHGLT00000002406
Ensembl Acc Id: ENSHGLP00000002356   ⟸   ENSHGLT00000002405


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001789 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000002403 ENTREZGENE
  ENSHGLT00000002404 ENTREZGENE
  ENSHGLT00000002405 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  Filamin UniProtKB/TrEMBL
  Filamin/ABP280_repeat-like UniProtKB/TrEMBL
  Filamin/ABP280_rpt UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
NCBI Gene Flna ENTREZGENE
PANTHER FILAMIN-A UniProtKB/TrEMBL
  FILAMIN-A UniProtKB/TrEMBL
  PTHR38537 UniProtKB/TrEMBL
Pfam Filamin UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  FILAMIN_REPEAT UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
SMART IG_FLMN UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A0P6J4A2 ENTREZGENE, UniProtKB/TrEMBL
  G5AVD8 ENTREZGENE, UniProtKB/TrEMBL