RGD Reference Report - Blood serum alpha fetoprotein enhancer binding protein, a tumor suppressor, decreases in chronic HBV hepatitis patients as hepatocellular cancer appears. - Rat Genome Database

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Blood serum alpha fetoprotein enhancer binding protein, a tumor suppressor, decreases in chronic HBV hepatitis patients as hepatocellular cancer appears.

Authors: Riggins, James N  Corey, William  Fonteh, Alfred N  Harrington, Michael G 
Citation: Riggins JN, etal., Dis Markers. 2010;28(3):125-35. doi: 10.3233/DMA-2010-0692.
RGD ID: 151361169
Pubmed: PMID:20534899   (View Abstract at PubMed)
PMCID: PMC3833326   (View Article at PubMed Central)
DOI: DOI:10.3233/DMA-2010-0692   (Journal Full-text)

Chronic hepatitis increases the risk of hepatocellular carcinoma (HCC). To test whether circulating proteins reflect hepatic carcinogenesis, sera from patients and controls were albumin depleted, enriched for glycoproteins, digested with trypsin, and subjected to reverse phase chromatography and tandem mass spectrometry. Alpha-fetoprotein enhancer binding protein (AFPebp), a tumor suppressor, was repeatedly identified in sera from chronic HBV hepatitis patients. We independently identified and quantified AFPebp with a deuterated, phenylisocyanate-labeled synthetic peptide standard. Elevated AFPebp levels in sera from chronic HBV hepatitis patients decreased as cancer developed. These data suggest that rising AFPebp levels in chronic HBV hepatitis may be protective, while falling levels may contribute to HCC development.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
autoimmune hepatitis  IEP 151361169protein:increased expression:blood serum (human)RGD 
autoimmune hepatitis  ISOZFHX3 (Homo sapiens)151361169; 151361169protein:increased expression:blood serum (human)RGD 
Chronic Hepatitis B  IEP 151361169protein:increased expression:blood serum (human)RGD 
Chronic Hepatitis B  ISOZFHX3 (Homo sapiens)151361169; 151361169protein:increased expression:blood serum (human)RGD 
hepatocellular carcinoma disease_progressionIEP 151361169associated with Chronic Hepatitis B and protein:decreased expression:blood serum (human)RGD 
hepatocellular carcinoma disease_progressionISOZFHX3 (Homo sapiens)151361169; 151361169associated with Chronic Hepatitis B and protein:decreased expression:blood serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Zfhx3  (zinc finger homeobox 3)

Genes (Mus musculus)
Zfhx3  (zinc finger homeobox 3)

Genes (Homo sapiens)
ZFHX3  (zinc finger homeobox 3)


Additional Information