Fas (Fas cell surface death receptor) - Rat Genome Database

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Gene: Fas (Fas cell surface death receptor) Heterocephalus glaber
Analyze
Symbol: Fas
Name: Fas cell surface death receptor
RGD ID: 18900547
Description: ENCODES a protein that exhibits identical protein binding (ortholog); kinase binding (ortholog); protease binding (ortholog); INVOLVED IN activation-induced cell death of T cells (ortholog); apoptotic process (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); FOUND IN apical dendrite (ortholog); apical plasma membrane (ortholog); CD95 death-inducing signaling complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tumor necrosis factor receptor superfamily member 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479115,289,348 - 15,315,848 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479115,290,022 - 15,315,848 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aplastic anemia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type IA  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Barrett's esophagus  (ISO)
Behcet's disease  (ISO)
brain glioma  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chest Trauma  (ISO)
chorioamnionitis  (ISO)
chronic conjunctivitis  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Uveitis  (ISO)
clonorchiasis  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
cryptorchidism  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Allergic Asthma  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Experimental Seizures  (ISO)
Familial Thoracic Aortic Aneurysm 6  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
graft-versus-host disease  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
HELLP syndrome  (ISO)
hematopoietic system disease  (ISO)
hepatitis B  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
heroin dependence  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hyperoxia  (ISO)
hypersplenism  (ISO)
Hypothermia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (ISO)
inclusion body myositis  (ISO)
infectious mononucleosis  (ISO)
Insulin Resistance  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (ISO)
limited scleroderma  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Lymphomatoid Papulosis  (ISO)
lymphoproliferative syndrome  (ISO)
macular degeneration  (ISO)
male infertility  (ISO)
melanoma  (ISO)
Metabolic Brain Diseases  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
mixed connective tissue disease  (ISO)
Moyamoya disease  (ISO)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Multisystemic Smooth Muscle Dysfunction Syndrome  (ISO)
myasthenia gravis  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
ocular hypertension  (ISO)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Parkinson's disease  (ISO)
peripheral vascular disease  (ISO)
Plasmodium falciparum malaria  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
primary biliary cholangitis  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
retinoblastoma  (ISO)
rheumatoid arthritis  (ISO)
sciatic neuropathy  (ISO)
seminoma  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (ISO)
Taste Disorders  (ISO)
Temporomandibular Joint Osteoarthritis  (ISO)
Testicular Injury  (ISO)
thoracic aortic aneurysm  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
varicocele  (ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (IEA,ISO)
apoptotic process  (IEA,ISO)
apoptotic signaling pathway  (ISO)
B cell mediated immunity  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to cobalt ion  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lithium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to phenylalanine  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
chordate embryonic development  (ISO)
circadian rhythm  (ISO)
dendrite regeneration  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
Fas signaling pathway  (ISO)
gene expression  (ISO)
hepatocyte apoptotic process  (ISO)
immune response  (IEA)
inflammatory cell apoptotic process  (ISO)
liver regeneration  (ISO)
lymphocyte apoptotic process  (ISO)
maternal process involved in female pregnancy  (ISO)
motor neuron apoptotic process  (IEA,ISO)
necroptotic signaling pathway  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of B cell activation  (ISO)
negative regulation of Schwann cell migration  (ISO)
negative regulation of Schwann cell proliferation  (ISO)
negative thymic T cell selection  (ISO)
neuron apoptotic process  (ISO)
ovarian follicle atresia  (ISO)
ovulation cycle  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of B cell differentiation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of hematopoietic progenitor cell differentiation  (ISO)
regulation of myeloid cell differentiation  (ISO)
regulation of stress-activated MAPK cascade  (IEA)
regulation of T cell differentiation  (ISO)
response to cycloheximide  (ISO)
response to cytokine  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to fluoride  (ISO)
response to glucocorticoid  (ISO)
response to growth factor  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
spermatogenesis  (ISO)
spleen development  (ISO)
T cell homeostasis  (ISO)
telencephalon development  (ISO)
tumor necrosis factor-mediated signaling pathway  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fas
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479115,289,348 - 15,315,848 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479115,290,022 - 15,315,848 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
FAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381088,964,050 - 89,017,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1088,953,813 - 89,029,605 (+)EnsemblGRCh38hg38GRCh38
GRCh371090,750,555 - 90,776,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,740,268 - 90,765,522 (+)NCBINCBI36Build 36hg18NCBI36
Build 341090,740,267 - 90,765,521NCBI
Celera1084,497,075 - 84,522,333 (+)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1084,384,755 - 84,410,009 (+)NCBIHuRef
CHM1_11091,032,348 - 91,057,602 (+)NCBICHM1_1
T2T-CHM13v2.01089,847,964 - 89,900,944 (+)NCBIT2T-CHM13v2.0
Fas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,267,926 - 34,305,175 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1934,268,066 - 34,305,172 (+)EnsemblGRCm39 Ensembl
GRCm381934,290,647 - 34,327,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,290,666 - 34,327,772 (+)EnsemblGRCm38mm10GRCm38
MGSCv371934,365,149 - 34,402,260 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361934,356,663 - 34,393,767 (+)NCBIMGSCv36mm8
Celera1935,067,780 - 35,104,920 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1929.48NCBI
Fas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,212,155 - 241,245,774 (+)NCBIGRCr8
mRatBN7.21231,798,963 - 231,832,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,798,960 - 231,832,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1240,190,049 - 240,223,613 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,111,767 - 247,145,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,949,944 - 239,983,507 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,589,785 - 252,624,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,589,785 - 252,624,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01259,812,248 - 259,846,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,259,443 - 238,274,745 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11238,423,465 - 238,438,767 (+)NCBI
Celera1228,912,823 - 228,946,152 (+)NCBICelera
Cytogenetic Map1q52NCBI
Fas
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554253,961,013 - 3,987,455 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554253,961,671 - 3,987,513 (-)NCBIChiLan1.0ChiLan1.0
FAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28100,988,835 - 101,033,839 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110101,002,414 - 101,045,621 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01085,707,457 - 85,741,539 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11089,199,070 - 89,244,884 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,217,949 - 89,243,612 (+)Ensemblpanpan1.1panPan2
FAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,738,811 - 38,763,298 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2638,737,611 - 38,763,321 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2638,489,983 - 38,514,797 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02640,322,559 - 40,347,441 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2640,322,604 - 40,347,428 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12638,193,452 - 38,217,927 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02637,756,887 - 37,781,708 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02639,027,502 - 39,052,301 (+)NCBIUU_Cfam_GSD_1.0
Fas
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721378,564,885 - 78,583,646 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936735209,369 - 234,582 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14100,927,089 - 100,956,716 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114100,927,305 - 100,954,781 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214109,911,730 - 109,939,489 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000004135   ⟹   ENSHGLP00000004077
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462479115,289,348 - 15,315,848 (+)Ensembl
RefSeq Acc Id: XM_021239153   ⟹   XP_021094812
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479115,290,022 - 15,315,848 (+)NCBI
RefSeq Acc Id: XM_021239154   ⟹   XP_021094813
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479115,290,022 - 15,315,848 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021094812 (Get FASTA)   NCBI Sequence Viewer  
  XP_021094813 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000004077
GenBank Protein JAN97957 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021094812   ⟸   XM_021239153
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021094813   ⟸   XM_021239154
- Peptide Label: isoform X2
- UniProtKB: A0A0N8ET11 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000004077   ⟸   ENSHGLT00000004135


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003005 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000004135 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  Fas_rcpt UniProtKB/TrEMBL
  TNFR/NGFR_Cys_rich_reg UniProtKB/TrEMBL
  TNFRSF6_death UniProtKB/TrEMBL
  TNFRSF6_N UniProtKB/TrEMBL
NCBI Gene Fas ENTREZGENE
PANTHER PTHR46874 UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  TNFR_c6 UniProtKB/TrEMBL
PRINTS TNFACTORR6 UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
  TNFR UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  TNF receptor-like UniProtKB/TrEMBL
UniProt A0A0N8ET11 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RAZ2_HETGA UniProtKB/TrEMBL