Top1 (DNA topoisomerase I) - Rat Genome Database

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Gene: Top1 (DNA topoisomerase I) Heterocephalus glaber
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Symbol: Top1
Name: DNA topoisomerase I
RGD ID: 18904153
Description: ENCODES a protein that exhibits ATP binding (ortholog); chromatin binding (ortholog); chromatin DNA binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to luteinizing hormone stimulus (ortholog); chromatin remodeling (ortholog); PARTICIPATES IN irinotecan pharmacodynamics pathway; irinotecan pharmacokinetics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); disease of cellular proliferation (ortholog); Disease Progression (ortholog); FOUND IN cytoplasm (ortholog); dense fibrillar component (ortholog); fibrillar center (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA topoisomerase 1; topoisomerase (DNA) I
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249191,668,440 - 1,756,629 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249191,668,712 - 1,756,624 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Top1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249191,668,440 - 1,756,629 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249191,668,712 - 1,756,624 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TOP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382041,028,822 - 41,124,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2041,028,822 - 41,124,487 (+)EnsemblGRCh38hg38GRCh38
GRCh372039,657,462 - 39,753,127 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362039,090,876 - 39,186,541 (+)NCBINCBI36Build 36hg18NCBI36
Build 342039,090,875 - 39,186,541NCBI
Celera2036,368,028 - 36,463,696 (+)NCBICelera
Cytogenetic Map20q12NCBI
HuRef2036,395,468 - 36,491,177 (+)NCBIHuRef
CHM1_12039,561,887 - 39,657,539 (+)NCBICHM1_1
T2T-CHM13v2.02042,760,511 - 42,856,164 (+)NCBIT2T-CHM13v2.0
Top1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392160,487,901 - 160,564,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2160,487,808 - 160,564,684 (+)EnsemblGRCm39 Ensembl
GRCm382160,645,897 - 160,722,764 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2160,645,888 - 160,722,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv372160,471,633 - 160,548,500 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362160,337,671 - 160,414,152 (+)NCBIMGSCv36mm8
Celera2166,577,915 - 166,654,823 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map280.96NCBI
Top1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83169,713,195 - 169,796,330 (+)NCBIGRCr8
mRatBN7.23149,293,469 - 149,376,618 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3149,293,403 - 149,376,623 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3153,107,309 - 153,188,513 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03161,606,688 - 161,687,898 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03159,345,818 - 159,427,549 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03156,635,688 - 156,717,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3156,642,464 - 156,717,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03162,865,335 - 162,947,076 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43151,428,931 - 151,512,884 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13151,334,966 - 151,418,920 (+)NCBI
Celera3147,968,261 - 148,049,789 (+)NCBICelera
Cytogenetic Map3q42NCBI
Top1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544515,834,017 - 15,922,785 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544515,834,017 - 15,922,785 (-)NCBIChiLan1.0ChiLan1.0
TOP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22146,769,898 - 46,866,351 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12046,762,969 - 46,859,450 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02037,368,606 - 37,464,649 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12038,468,197 - 38,563,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2038,468,452 - 38,562,652 (+)Ensemblpanpan1.1panPan2
TOP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12429,075,267 - 29,166,733 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2429,075,492 - 29,165,864 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2428,720,984 - 28,812,380 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02429,781,234 - 29,872,485 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2429,781,498 - 29,872,296 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12429,049,969 - 29,141,401 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02429,153,861 - 29,245,250 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02429,650,217 - 29,741,420 (+)NCBIUU_Cfam_GSD_1.0
Top1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640178,026,161 - 178,108,033 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936561641,423 - 723,518 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936561641,451 - 723,323 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1743,710,290 - 43,799,700 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11743,710,270 - 43,799,700 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21749,135,554 - 49,193,582 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1222,655,085 - 22,751,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl222,651,995 - 22,751,102 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605071,467,009 - 71,562,443 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000001488   ⟹   ENSHGLP00000001444
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249191,668,440 - 1,756,629 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000001489   ⟹   ENSHGLP00000001445
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249191,697,206 - 1,755,447 (+)Ensembl
RefSeq Acc Id: XM_004874029   ⟹   XP_004874086
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249191,668,712 - 1,756,624 (+)NCBI
RefSeq Acc Id: XM_021251582   ⟹   XP_021107241
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249191,734,677 - 1,756,624 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004874086 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107241 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001444
  ENSHGLP00100016715
GenBank Protein JAO01541 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004874086   ⟸   XM_004874029
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JX70 (UniProtKB/TrEMBL),   G5C9N0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021107241   ⟸   XM_021251582
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000001445   ⟸   ENSHGLT00000001489
Ensembl Acc Id: ENSHGLP00000001444   ⟸   ENSHGLT00000001488


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001115 Ensembl, ENTREZGENE
  ENSHGLG00100012334 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000001488 ENTREZGENE
  ENSHGLT00100016895 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.41 UniProtKB/TrEMBL
  1.10.132.10 UniProtKB/TrEMBL
  2.170.11.10 UniProtKB/TrEMBL
InterPro DNA_brk_join_enz UniProtKB/TrEMBL
  DNA_topo_DNA_db_N_dom1 UniProtKB/TrEMBL
  DNA_topo_DNA_db_N_dom2 UniProtKB/TrEMBL
  TopoI UniProtKB/TrEMBL
  TopoI_AS UniProtKB/TrEMBL
  TopoI_C_dom UniProtKB/TrEMBL
  TopoI_cat_a-hlx-sub_euk UniProtKB/TrEMBL
  TopoI_cat_a/b-sub_euk UniProtKB/TrEMBL
  TopoI_cat_euk UniProtKB/TrEMBL
  TopoI_DNA-bd_euk UniProtKB/TrEMBL
  TopoI_DNA-bd_euk_N_sf UniProtKB/TrEMBL
  TopoI_euk UniProtKB/TrEMBL
  Topoisomer_I_DNA-bd UniProtKB/TrEMBL
  Topoisomerase_IB UniProtKB/TrEMBL
KEGG Report hgl:101704241 UniProtKB/TrEMBL
NCBI Gene Top1 ENTREZGENE
PANTHER DNA TOPOISOMERASE 1 UniProtKB/TrEMBL
  DNA TOPOISOMERASE I UniProtKB/TrEMBL
Pfam Topo_C_assoc UniProtKB/TrEMBL
  Topoisom_I UniProtKB/TrEMBL
  Topoisom_I_N UniProtKB/TrEMBL
PRINTS EUTPISMRASEI UniProtKB/TrEMBL
PROSITE TOPOISOMERASE_I_EUK UniProtKB/TrEMBL
SMART TOPEUc UniProtKB/TrEMBL
Superfamily-SCOP Eukaryotic DNA topoisomerase I, dispensable insert domain UniProtKB/TrEMBL
  SSF56349 UniProtKB/TrEMBL
  SSF56741 UniProtKB/TrEMBL
UniProt A0A0P6JX70 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SFA7_HETGA UniProtKB/TrEMBL
  G5C9N0 ENTREZGENE, UniProtKB/TrEMBL