Irs1 (insulin receptor substrate 1) - Rat Genome Database

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Pathways
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Gene: Irs1 (insulin receptor substrate 1) Heterocephalus glaber
Analyze
Symbol: Irs1
Name: insulin receptor substrate 1
RGD ID: 18905749
Description: ENCODES a protein that exhibits insulin receptor binding (ortholog); insulin-like growth factor receptor binding (ortholog); phosphatidylinositol 3-kinase activator activity (ortholog); INVOLVED IN cell migration (ortholog); cellular response to angiotensin (ortholog); cellular response to brain-derived neurotrophic factor stimulus (ortholog); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH AIDS Dementia Complex (ortholog); Alzheimer's disease (ortholog); coronary artery disease (ortholog); FOUND IN caveola (ortholog); ciliary basal body (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248431,120,974 - 1,178,859 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248431,113,075 - 1,178,859 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell migration  (ISO)
cellular response to angiotensin  (ISO)
cellular response to brain-derived neurotrophic factor stimulus  (ISO)
cellular response to fatty acid  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to radiation  (ISO)
cytokine-mediated signaling pathway  (ISO)
epithelial cell migration  (ISO)
insulin receptor signaling pathway  (IEA,ISO)
insulin secretion  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
lipid catabolic process  (ISO)
mammary gland development  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of somatostatin secretion  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of fatty acid beta-oxidation  (ISO)
positive regulation of glucagon secretion  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phosphorylation  (ISO)
protein localization to nucleus  (ISO)
regulation of gene expression  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to insulin  (ISO)
signal transduction  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:26763976   PMID:30032202  


Genomics

Comparative Map Data
Irs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248431,120,974 - 1,178,859 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248431,113,075 - 1,178,859 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IRS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382226,731,312 - 226,799,820 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2226,731,312 - 226,799,820 (-)EnsemblGRCh38hg38GRCh38
GRCh372227,596,028 - 227,664,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,308,182 - 227,372,719 (-)NCBINCBI36Build 36hg18NCBI36
Build 342227,425,442 - 227,489,980NCBI
Celera2221,365,560 - 221,433,036 (-)NCBICelera
Cytogenetic Map2q36.3NCBI
HuRef2219,439,592 - 219,507,082 (-)NCBIHuRef
CHM1_12227,601,926 - 227,669,382 (-)NCBICHM1_1
T2T-CHM13v2.02227,214,139 - 227,282,678 (-)NCBIT2T-CHM13v2.0
Irs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39182,210,826 - 82,269,160 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl182,210,822 - 82,269,137 (-)EnsemblGRCm39 Ensembl
GRCm38182,233,105 - 82,291,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl182,233,101 - 82,291,416 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl182,233,112 - 82,235,933 (+)EnsemblGRCm38mm10GRCm38
MGSCv37182,229,680 - 82,288,014 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36182,115,634 - 82,170,440 (-)NCBIMGSCv36mm8
Celera182,301,640 - 82,360,019 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map142.0NCBI
Irs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8991,001,137 - 91,053,959 (-)NCBIGRCr8
mRatBN7.2983,552,964 - 83,605,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl983,548,944 - 83,606,122 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx991,983,252 - 92,036,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0997,111,732 - 97,164,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0995,494,674 - 95,547,492 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0988,033,668 - 88,086,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl988,033,668 - 88,086,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0987,782,499 - 87,835,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4981,585,251 - 81,638,071 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1981,768,669 - 81,821,490 (-)NCBI
Celera980,997,490 - 81,050,250 (-)NCBICelera
Cytogenetic Map9q34NCBI
Irs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554537,685,715 - 7,742,262 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554537,685,715 - 7,742,262 (+)NCBIChiLan1.0ChiLan1.0
IRS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213129,350,601 - 129,415,120 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B129,365,570 - 129,430,086 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B113,973,191 - 114,041,127 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B232,785,822 - 232,853,997 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B232,849,239 - 232,852,967 (-)Ensemblpanpan1.1panPan2
IRS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12539,624,554 - 39,687,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2540,246,368 - 40,306,296 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02539,876,307 - 39,936,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2539,932,409 - 39,936,152 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12539,811,057 - 39,873,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02539,647,771 - 39,707,665 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02539,826,700 - 39,886,691 (-)NCBIUU_Cfam_GSD_1.0
Irs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303181,813,749 - 181,875,259 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365259,064,466 - 9,122,635 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365259,064,442 - 9,125,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15128,245,846 - 128,307,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115128,245,846 - 128,307,321 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215142,086,134 - 142,147,797 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110112,748,283 - 112,812,368 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604086,628,478 - 86,694,818 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000027693   ⟹   ENSHGLP00000027450
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248431,120,974 - 1,178,859 (-)Ensembl
RefSeq Acc Id: XM_004867975   ⟹   XP_004868032
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248431,120,974 - 1,178,859 (-)NCBI
RefSeq Acc Id: XM_004867976   ⟹   XP_004868033
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248431,113,075 - 1,178,674 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004868032 (Get FASTA)   NCBI Sequence Viewer  
  XP_004868033 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AIZ09014 (Get FASTA)   NCBI Sequence Viewer  
  EHB18158 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000027450
Reference Protein Sequences
RefSeq Acc Id: XP_004868033   ⟸   XM_004867976
- UniProtKB: G5C9E7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004868032   ⟸   XM_004867975
- UniProtKB: G5C9E7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000027450   ⟸   ENSHGLT00000027693


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019521 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000027693 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro IRS UniProtKB/TrEMBL
  IRS_PTB UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
KEGG Report hgl:101708189 UniProtKB/TrEMBL
NCBI Gene Irs1 ENTREZGENE
PANTHER INSULIN RECEPTOR SUBSTRATE 1 UniProtKB/TrEMBL
  PTHR10614 UniProtKB/TrEMBL
Pfam IRS UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PRINTS INSULINRSI UniProtKB/TrEMBL
PROSITE IRS_PTB UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART IRS UniProtKB/TrEMBL
  PTBI UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt G5C9E7 ENTREZGENE, UniProtKB/TrEMBL