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[Downregulation of chromobox protein homolog 7 expression in multiple human cancer tissues]

Authors: Guan, ZP  Gu, LK  Xing, BC  Ji, JF  Gu, J  Deng, DJ 
Citation: Guan ZP, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jul;45(7):597-600.
Pubmed: (View Article at PubMed) PMID:22041561

OBJECTIVE: To investigate the relationship between chromobox protein homolog 7 (cbx7) expression and the occurrence and development of colorectal carcinoma (CRC), gastric carcinoma (GC) and hepatocarcinoma (HCC) tissues. METHODS: The samples of neoplastic tissues and the corresponding cutting-edge normal tissues from 22 cases of CRC, 20 cases of GC, 30 cases of HCC were surgically collected. Level of cbx7 mRNA was detected with a fluorescent quantitative RT-PCR assay, and the correlationship among expression of cbx7 mRNA, the patients' clinicopathologic features and the surviving time after surgery was analyzed. RESULTS: The relative copy number of cbx7 mRNA in carcinomas and the normal tissues was 0.010 +/- 0.015 vs 0.053 +/- 0.042 for CRCs, 0.197 +/- 0.195 vs 1.891 +/- 1.254 for GCs, and 0.008 +/- 0.008 vs 0.030 +/- 0.021 for HCCs, respectively. Compared with the corresponding normal tissues, cbx7 expression was significantly downregulated in CRCs, GCs, and HCCs (t = -7.351, -5.417 and -6.680, respectively, P < 0.01). The expression of cbx7 mRNA in CRCs had significant differences not only between two age groups (the relative copy number of cbx7 mRNA in age > 55 group was 0.007 +/- 0.015, but 0.017 +/- 0.012 in age


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RGD Object Information
RGD ID: 9587355
Created: 2014-10-08
Species: All species
Last Modified: 2014-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.