Ift88 (intraflagellar transport 88) - Rat Genome Database

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Gene: Ift88 (intraflagellar transport 88) Heterocephalus glaber
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Symbol: Ift88
Name: intraflagellar transport 88
RGD ID: 18915102
Description: ENCODES a protein that exhibits kinesin binding (inferred); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); brain development (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH asphyxiating thoracic dystrophy (ortholog); autosomal dominant nonsyndromic deafness 3B (ortholog); autosomal recessive nonsyndromic deafness 1A (ortholog); FOUND IN acrosomal membrane (ortholog); axonemal basal plate (ortholog); axoneme (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: intraflagellar transport 88 homolog; intraflagellar transport protein 88 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477616,954,507 - 17,086,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477616,954,368 - 17,086,377 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
brain development  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac septum morphogenesis  (ISO)
cilium assembly  (ISO)
cilium movement  (ISO)
cochlea development  (ISO)
cytoplasmic microtubule organization  (ISO)
determination of left/right symmetry  (ISO)
dorsal/ventral pattern formation  (ISO)
embryonic digit morphogenesis  (ISO)
endothelial cell morphogenesis  (ISO)
epidermal stem cell homeostasis  (ISO)
epidermis development  (ISO)
eye development  (ISO)
forebrain development  (ISO)
forebrain morphogenesis  (ISO)
heart development  (ISO)
heart formation  (ISO)
inner ear receptor cell stereocilium organization  (IEA,ISO)
intraciliary transport  (IEA)
keratinocyte proliferation  (ISO)
kidney development  (IEA,ISO)
limb development  (ISO)
liver development  (ISO)
lung development  (ISO)
lung vasculature development  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of keratinocyte proliferation  (ISO)
nervous system development  (ISO)
neural precursor cell proliferation  (ISO)
non-motile cilium assembly  (IEA,ISO)
Notch signaling pathway  (ISO)
pancreas development  (ISO)
positive regulation of cilium assembly  (IEA)
positive regulation of insulin-like growth factor receptor signaling pathway  (ISO)
primary palate development  (ISO)
protein localization  (ISO)
regulation of autophagosome assembly  (ISO)
regulation of cilium assembly  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of feeding behavior  (ISO)
regulation of odontogenesis of dentin-containing tooth  (ISO)
regulation of protein processing  (ISO)
response to fluid shear stress  (ISO)
response to silicon dioxide  (ISO)
smoothened signaling pathway  (ISO)
sperm axoneme assembly  (ISO)
spermatid nucleus elongation  (ISO)
spinal cord dorsal/ventral patterning  (ISO)
telencephalon development  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Ift88
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477616,954,507 - 17,086,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477616,954,368 - 17,086,377 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IFT88
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381320,567,157 - 20,691,444 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1320,567,138 - 20,691,444 (+)EnsemblGRCh38hg38GRCh38
GRCh371321,141,296 - 21,265,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361320,039,208 - 20,163,576 (+)NCBINCBI36Build 36hg18NCBI36
Celera132,203,136 - 2,327,509 (+)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef131,944,935 - 2,068,758 (+)NCBIHuRef
CHM1_11321,109,386 - 21,233,717 (+)NCBICHM1_1
T2T-CHM13v2.01319,760,320 - 19,884,580 (+)NCBIT2T-CHM13v2.0
Ift88
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391457,661,519 - 57,755,393 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1457,661,519 - 57,755,393 (+)EnsemblGRCm39 Ensembl
GRCm381457,424,064 - 57,517,936 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1457,424,062 - 57,517,936 (+)EnsemblGRCm38mm10GRCm38
MGSCv371458,042,908 - 58,136,773 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361456,378,236 - 56,472,046 (+)NCBIMGSCv36mm8
Celera1455,219,087 - 55,313,152 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.1NCBI
Ift88
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81535,685,678 - 35,786,875 (+)NCBIGRCr8
mRatBN7.21531,573,325 - 31,666,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1531,573,376 - 31,672,147 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1533,564,745 - 33,657,387 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01534,715,428 - 34,808,071 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01532,973,502 - 33,066,150 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01537,690,417 - 37,786,855 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,691,345 - 37,784,924 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01541,536,303 - 41,630,808 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41536,468,007 - 36,560,959 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11536,489,464 - 36,576,142 (+)NCBI
Celera1531,284,577 - 31,376,920 (+)NCBICelera
Cytogenetic Map15p12NCBI
Ift88
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554971,338,904 - 1,455,122 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554971,338,959 - 1,454,788 (+)NCBIChiLan1.0ChiLan1.0
IFT88
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21420,196,253 - 20,320,900 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11311,308,391 - 11,433,407 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0131,893,102 - 2,017,771 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11320,205,881 - 20,331,204 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1320,206,471 - 20,331,204 (+)Ensemblpanpan1.1panPan2
IFT88
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12517,414,965 - 17,551,405 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2517,414,965 - 17,551,266 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2517,446,483 - 17,582,062 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02517,553,518 - 17,689,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2517,553,521 - 17,689,059 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12517,424,524 - 17,560,075 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02517,436,123 - 17,571,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02517,493,013 - 17,628,598 (-)NCBIUU_Cfam_GSD_1.0
Ift88
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945119,493,700 - 119,621,206 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367201,041,211 - 1,168,748 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367201,041,216 - 1,168,725 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFT88
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl11943,469 - 1,025,613 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.111943,444 - 1,025,617 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.211303,752 - 344,218 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IFT88
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.13435,649 - 546,661 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl3436,207 - 546,583 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605744,044,574 - 44,161,084 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000014928   ⟹   ENSHGLP00000014783
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462477616,954,507 - 17,086,337 (-)Ensembl
RefSeq Acc Id: XM_004854873   ⟹   XP_004854930
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477616,954,368 - 17,086,377 (-)NCBI
RefSeq Acc Id: XM_013075877   ⟹   XP_012931331
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477616,954,368 - 17,086,377 (-)NCBI
RefSeq Acc Id: XM_013075879   ⟹   XP_012931333
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477616,954,484 - 17,086,377 (-)NCBI
RefSeq Acc Id: XM_013075880   ⟹   XP_012931334
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477616,954,368 - 17,055,007 (-)NCBI
RefSeq Acc Id: XM_021236373   ⟹   XP_021092032
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477616,954,368 - 17,086,377 (-)NCBI
RefSeq Acc Id: XR_002386189
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477616,954,580 - 17,086,377 (-)NCBI
RefSeq Acc Id: XP_021092032   ⟸   XM_021236373
- Peptide Label: isoform X2
- UniProtKB: G5BKV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012931331   ⟸   XM_013075877
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004854930   ⟸   XM_004854873
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JWA8 (UniProtKB/TrEMBL),   G5BKV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012931334   ⟸   XM_013075880
- Peptide Label: isoform X5
RefSeq Acc Id: XP_012931333   ⟸   XM_013075879
- Peptide Label: isoform X4
Ensembl Acc Id: ENSHGLP00000014783   ⟸   ENSHGLT00000014928


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010561 Ensembl, ENTREZGENE
  ENSHGLG00100008106 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000014928 ENTREZGENE
  ENSHGLT00100044026 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
KEGG Report hgl:101707870 UniProtKB/TrEMBL
NCBI Gene Ift88 ENTREZGENE
PANTHER INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG UniProtKB/TrEMBL
  INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG UniProtKB/TrEMBL
Pfam TPR_12 UniProtKB/TrEMBL
  TPR_16 UniProtKB/TrEMBL
  TPR_6 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PROSITE TPR UniProtKB/TrEMBL
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A0P6JWA8 ENTREZGENE, UniProtKB/TrEMBL
  G5BKV6 ENTREZGENE, UniProtKB/TrEMBL