Txnip (thioredoxin interacting protein) - Rat Genome Database

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Gene: Txnip (thioredoxin interacting protein) Heterocephalus glaber
Analyze
Symbol: Txnip
Name: thioredoxin interacting protein
RGD ID: 18915192
Description: ENCODES a protein that exhibits enzyme inhibitor activity (ortholog); INVOLVED IN cellular response to tumor cell (ortholog); keratinocyte differentiation (ortholog); negative regulation of cell division (ortholog); ASSOCIATED WITH colorectal cancer (ortholog); COVID-19 (ortholog); Diabetic Nephropathies (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Thioredoxin-interacting protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,341,630 - 17,345,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,341,918 - 17,345,964 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Txnip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,341,630 - 17,345,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,341,918 - 17,345,964 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TXNIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,992,435 - 145,996,579 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1145,992,435 - 145,996,579 (-)EnsemblGRCh38hg38GRCh38
GRCh371145,438,490 - 145,442,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,149,939 - 144,153,882 (+)NCBINCBI36Build 36hg18NCBI36
Build 341142,927,625 - 142,931,567NCBI
Celera1119,641,815 - 119,645,987 (+)NCBICelera
Cytogenetic Map1q21.1NCBI
HuRef1119,402,325 - 119,406,521 (+)NCBIHuRef
CHM1_11147,360,561 - 147,364,757 (-)NCBICHM1_1
T2T-CHM13v2.01145,109,270 - 145,113,414 (-)NCBIT2T-CHM13v2.0
Txnip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,465,273 - 96,469,173 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,465,273 - 96,469,199 (+)EnsemblGRCm39 Ensembl
GRCm38396,557,957 - 96,561,857 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,557,957 - 96,561,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,361,880 - 96,365,780 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,643,362 - 96,647,271 (+)NCBIMGSCv36mm8
Celera397,964,967 - 97,968,875 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.93NCBI
Txnip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,781,933 - 186,785,736 (+)NCBIGRCr8
mRatBN7.22184,093,079 - 184,096,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,092,991 - 184,096,886 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,764,537 - 191,768,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,557,131 - 189,560,931 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,397,095 - 184,400,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,683,168 - 198,686,971 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,683,159 - 198,686,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,170,102 - 218,173,905 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,356,954 - 191,360,757 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,319,631 - 191,323,506 (+)NCBI
Celera2176,618,301 - 176,622,104 (+)NCBICelera
Cytogenetic Map2q34NCBI
Txnip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568103,762 - 107,785 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568103,801 - 107,791 (+)NCBIChiLan1.0ChiLan1.0
LOC100971374
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21105,244,606 - 105,248,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11104,844,009 - 104,850,270 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0190,007,878 - 90,012,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11113,902,839 - 113,906,239 (-)NCBIpanpan1.1PanPan1.1panPan2
TXNIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,775,588 - 58,779,730 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,776,871 - 58,779,531 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,243,550 - 58,247,684 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,772,252 - 59,776,384 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,772,252 - 59,776,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,645,076 - 58,649,209 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,706,219 - 58,710,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,432,672 - 59,436,806 (-)NCBIUU_Cfam_GSD_1.0
Txnip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,846,422 - 20,850,485 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936867722,514 - 726,617 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936867722,544 - 726,595 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,348,490 - 99,352,755 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,348,589 - 99,351,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,991,390 - 108,994,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TXNIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12012,756,145 - 12,759,853 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2012,756,053 - 12,761,177 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603815,433,418 - 15,437,640 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000007207   ⟹   ENSHGLP00000007122
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462477217,341,630 - 17,345,960 (-)Ensembl
RefSeq Acc Id: XM_004853925   ⟹   XP_004853982
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477217,341,918 - 17,345,964 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004853982 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB06695 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007122
  ENSHGLP00100022309
GenBank Protein JAO01227 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004853982   ⟸   XM_004853925
- UniProtKB: G5BBN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000007122   ⟸   ENSHGLT00000007207


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005199 Ensembl, ENTREZGENE
  ENSHGLG00100016417 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000007207 ENTREZGENE
  ENSHGLT00100022542 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.640 UniProtKB/TrEMBL
InterPro Arrestin-like_C UniProtKB/TrEMBL
  Arrestin-like_N UniProtKB/TrEMBL
  Arrestin_C-like UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
KEGG Report hgl:101705419 UniProtKB/TrEMBL
NCBI Gene Txnip ENTREZGENE
PANTHER ARRESTIN DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  THIOREDOXIN-INTERACTING PROTEIN UniProtKB/TrEMBL
Pfam Arrestin_C UniProtKB/TrEMBL
  Arrestin_N UniProtKB/TrEMBL
SMART Arrestin_C UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/TrEMBL
UniProt G5BBN4 ENTREZGENE, UniProtKB/TrEMBL