Spc25 (SPC25 component of NDC80 kinetochore complex) - Rat Genome Database

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Gene: Spc25 (SPC25 component of NDC80 kinetochore complex) Heterocephalus glaber
Analyze
Symbol: Spc25
Name: SPC25 component of NDC80 kinetochore complex
RGD ID: 18909114
Description: INVOLVED IN attachment of spindle microtubules to kinetochore (ortholog); mitotic spindle organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytosol (ortholog); Ndc80 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kinetochore protein Spc25; SPC25, NDC80 kinetochore complex component
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,608,039 - 6,624,597 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,608,403 - 6,624,533 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Spc25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,608,039 - 6,624,597 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,608,403 - 6,624,533 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SPC25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382168,861,521 - 168,890,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2168,834,132 - 168,913,371 (-)EnsemblGRCh38hg38GRCh38
GRCh372169,727,401 - 169,746,940 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,435,647 - 169,455,190 (-)NCBINCBI36Build 36hg18NCBI36
Celera2163,352,703 - 163,372,246 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2161,623,412 - 161,643,117 (-)NCBIHuRef
CHM1_12169,733,212 - 169,752,754 (-)NCBICHM1_1
T2T-CHM13v2.02169,319,011 - 169,364,874 (-)NCBIT2T-CHM13v2.0
Spc25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,009,753 - 69,036,583 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,024,239 - 69,036,538 (-)EnsemblGRCm39 Ensembl
GRCm38269,193,895 - 69,206,213 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,193,895 - 69,206,194 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,031,953 - 69,044,214 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36268,994,735 - 69,006,996 (-)NCBIMGSCv36mm8
Celera270,859,628 - 70,872,362 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.64NCBI
Spc25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,337,872 - 74,396,825 (-)NCBIGRCr8
mRatBN7.2353,930,013 - 53,988,940 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl353,975,704 - 53,988,959 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,376,126 - 57,389,267 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0365,959,682 - 65,972,823 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,721,842 - 63,735,020 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,438,534 - 55,451,961 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,438,536 - 55,451,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,050,000 - 62,063,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,361,185 - 51,374,357 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1351,257,558 - 51,270,729 (-)NCBI
Celera353,537,785 - 53,550,955 (-)NCBICelera
Cytogenetic Map3q21NCBI
Spc25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,533,450 - 5,557,835 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,533,464 - 5,556,341 (+)NCBIChiLan1.0ChiLan1.0
SPC25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,532,236 - 71,574,186 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,547,209 - 71,589,160 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,148,325 - 56,190,851 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,613,457 - 173,632,947 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,613,457 - 173,655,791 (-)Ensemblpanpan1.1panPan2
SPC25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,697,389 - 13,710,367 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,697,456 - 13,710,635 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,708,404 - 13,721,357 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03613,813,505 - 13,826,418 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3613,813,585 - 13,826,318 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,898,536 - 13,911,444 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,885,686 - 13,899,255 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03613,999,234 - 14,012,225 (-)NCBIUU_Cfam_GSD_1.0
Spc25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,965,506 - 130,989,530 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,628,230 - 10,652,232 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,628,235 - 10,652,168 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPC25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,336,514 - 75,371,277 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,339,171 - 75,371,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,441,925 - 84,474,848 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPC25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,390,300 - 54,423,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1054,403,157 - 54,423,245 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040145,110,045 - 145,152,265 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000006542   ⟹   ENSHGLP00000006460
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247876,608,039 - 6,624,597 (-)Ensembl
RefSeq Acc Id: XM_004857615   ⟹   XP_004857672
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247876,608,403 - 6,624,533 (-)NCBI
RefSeq Acc Id: XM_004857616   ⟹   XP_004857673
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247876,608,403 - 6,624,533 (-)NCBI
RefSeq Acc Id: XM_013076940   ⟹   XP_012932394
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247876,608,403 - 6,624,098 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004857672 (Get FASTA)   NCBI Sequence Viewer  
  XP_004857673 (Get FASTA)   NCBI Sequence Viewer  
  XP_012932394 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000006460
  ENSHGLP00000042789
  ENSHGLP00100034251
Reference Protein Sequences
RefSeq Acc Id: XP_004857673   ⟸   XM_004857616
- Peptide Label: isoform X2
- UniProtKB: G5C8R1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004857672   ⟸   XM_004857615
- Peptide Label: isoform X1
- UniProtKB: G5C8R1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012932394   ⟸   XM_013076940
- Peptide Label: isoform X2
- UniProtKB: G5C8R1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000006460   ⟸   ENSHGLT00000006542


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004724 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100001708 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000006542 ENTREZGENE
  ENSHGLT00000071367 UniProtKB/TrEMBL
  ENSHGLT00100054337 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.1950 UniProtKB/TrEMBL
InterPro Spc25 UniProtKB/TrEMBL
  Spc25_C UniProtKB/TrEMBL
NCBI Gene Spc25 ENTREZGENE
PANTHER KINETOCHORE PROTEIN SPC25 UniProtKB/TrEMBL
  KINETOCHORE PROTEIN SPC25-RELATED UniProtKB/TrEMBL
Pfam Spindle_Spc25 UniProtKB/TrEMBL
UniProt G5C8R1 ENTREZGENE, UniProtKB/TrEMBL